Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Srinivasa-Gopalan Sampathkumar"'
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217369 (2019)
Multivalent proteins or protein dendrimers are useful for clinical and biotechnological applications. However, assembly of chemically defined protein dendrimers is a challenging endeavor. In the past, majority of protein dendrimers have been develope
Externí odkaz:
https://doaj.org/article/aa767f73ba1a4ebea9750db4c9d63f0d
Autor:
Anam Tasneem, Shubham Parashar, Simran Aittan, Tanya Jain, Charu Chauhan, Jyoti Rautela, Zahoor Ahmad Bhat, Kaisar Raza, Arumugam Madhumalar, Srinivasa-Gopalan Sampathkumar
Sialyl-Lewis-X (sLeX/CD15s) epitopes regulate cell adhesionviainteractions with selectins. High levels of sLeX are associated with chronic inflammation. Intense efforts have been devoted for the development of sLeX mimetics for the prevention of athe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c38e1882d99b85aee74e5d30bca08b8b
https://doi.org/10.1101/2021.12.22.473788
https://doi.org/10.1101/2021.12.22.473788
Autor:
Umesh K, Mishra, Yogesh S, Sanghvi, R, Abhiraj, Srinivasa-Gopalan, Sampathkumar, Namakkal G, Ramesh
Publikováno v:
Carbohydrate Research. 520:108645
A glycal based expeditious synthesis of novel nucleoside analogues of (+)-anisomycin is reported. Readily available tri-O-benzyl-D-glucal was converted to a partially protected trihydroxypyrrolidine that is used as a common scaffold for the introduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295b213691de2b2b8cf754d74da51c69
https://doi.org/10.1016/j.carres.2022.108645
https://doi.org/10.1016/j.carres.2022.108645
Autor:
Aristotelis Antonopoulos, Alan E. Friedman, Monika Garg, Joseph T.Y. Lau, Xinheng Yu, Sriram Neelamegham, Shuen-Shiuan Wang, Virginia del Solar, Anne Dell, Mehrab Nasirikenari, Srinivasa-Gopalan Sampathkumar, Syed Meheboob Ahmed, Ahana Addya, Kavita Agarwal, Stuart M. Haslam
SUMMARYThere is a critical need to develop small molecule inhibitors of mucin-type O-linked glycosylation. The best known reagent currently is peracetylated benzyl-GalNAc, but it is only effective at millimolar concentrations. This manuscript demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07a96dae444101e4722b65caf19463a5
https://doi.org/10.1101/2020.12.13.422539
https://doi.org/10.1101/2020.12.13.422539
Publikováno v:
Biochemical and Biophysical Research Communications. 506:60-65
Investigations on the structure and functional roles of glycosylation - an intricate, complex, and dynamic post translational modification on proteins - in biological processes has been a challenging task. Glycan modifications vary depending on the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37600ea240533d0d6779ef2011bbf07c
https://doi.org/10.1016/j.bbrc.2018.08.131
https://doi.org/10.1016/j.bbrc.2018.08.131
Autor:
Shuen-Shiuan, Wang, Virginia Del, Solar, Xinheng, Yu, Aristotelis, Antonopoulos, Alan E, Friedman, Kavita, Agarwal, Monika, Garg, Syed Meheboob, Ahmed, Ahana, Addhya, Mehrab, Nasirikenari, Joseph T, Lau, Anne, Dell, Stuart M, Haslam, Srinivasa-Gopalan, Sampathkumar, Sriram, Neelamegham
Publikováno v:
Cell Chem Biol
There is a critical need to develop small molecule inhibitors of mucin-type O-linked glycosylation. The best-known reagent currently is benzyl-GalNAc, but it is only effective at millimolar concentrations. This manuscript demonstrates that Ac(5)GalNT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::478c013f7af2420ef457ea085bc37402
https://pubmed.ncbi.nlm.nih.gov/33609441
https://pubmed.ncbi.nlm.nih.gov/33609441
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0217369 (2019)
PLoS ONE, Vol 14, Iss 5, p e0217369 (2019)
Multivalent proteins or protein dendrimers are useful for clinical and biotechnological applications. However, assembly of chemically defined protein dendrimers is a challenging endeavor. In the past, majority of protein dendrimers have been develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50b51867ac3e1776f9cfc2a0a0eed17
http://europepmc.org/articles/PMC6534326
http://europepmc.org/articles/PMC6534326
Autor:
Sriram Neelamegham, Virginia del Solar, Joseph T.Y. Lau, Xinheng Yu, Stuart M. Haslam, Ahana Addhya, Monika Garg, Anne Dell, Shuen-Shiuan Wang, Kavita Agarwal, Syed Meheboob Ahmed, Alan E. Friedman, Srinivasa-Gopalan Sampathkumar, Mehrab Nasirikenari, Aristotelis Antonopoulos
Publikováno v:
Cell Chemical Biology. 28:699-710.e5
Summary There is a critical need to develop small-molecule inhibitors of mucin-type O-linked glycosylation. The best-known reagent currently is benzyl-GalNAc, but it is effective only at millimolar concentrations. This article demonstrates that Ac5Ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4802e654e4e6fd566283626678025b7e
https://doi.org/10.1016/j.chembiol.2021.01.017
https://doi.org/10.1016/j.chembiol.2021.01.017
Autor:
Vandita, Dwivedi, Pratima, Saini, Anam, Tasneem, Kavita, Agarwal, Srinivasa-Gopalan, Sampathkumar
Publikováno v:
Biochemical and biophysical research communications. 506(1)
Investigations on the structure and functional roles of glycosylation - an intricate, complex, and dynamic post translational modification on proteins - in biological processes has been a challenging task. Glycan modifications vary depending on the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c720aeeb8bd88955afab021dd3ab8ae4
https://pubmed.ncbi.nlm.nih.gov/30336974
https://pubmed.ncbi.nlm.nih.gov/30336974
Autor:
Shubham Parashar, Vandita Dwivedi, Asif Shajahan, Srinivasa-Gopalan Sampathkumar, Surbhi Goswami
Publikováno v:
Emerging topics in life sciences. 2(3)
Owing to its poly-anionic charge and large hydrodynamic volume, polysialic acid (polySia) attached to neural cell adhesion molecule regulates axon–axon and axon–substratum interactions and signalling, particularly, in the development of the centr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3feab1af1fad506aa69c8fcca9d9d3
https://pubmed.ncbi.nlm.nih.gov/33525793
https://pubmed.ncbi.nlm.nih.gov/33525793