Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Srinivasa R. Mantena"'
Autor:
Brett D. Hollingshead, Anna K. Kopec, Yutian Zhan, Timothy P. LaBranche, John W. Davis, Kyle Hayes, Srinivasa R. Mantena, Andrew W. Harrington, Laurence O. Whiteley, Zachary S. Stewart, Andrew D. Burdick
Publikováno v:
Toxicologic Pathology. 48:994-1007
Fatty liver disease is a potential risk factor for drug-induced liver injury (DILI). Despite advances in nonclinical in vitro and in vivo models to assess liver injury during drug development, the pharmaceutical industry is still plagued by idiosyncr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345317f50829520d91ae5176802b72bd
https://doi.org/10.1177/0192623320968716
https://doi.org/10.1177/0192623320968716
Autor:
Denise Wilcox, Vasudha Sehgal, Daniel H. Albert, John K. Pratt, Keith F. McDaniel, Xin Lu, Chaohong Sun, Dachun Liu, Joshua P. Plotnik, Srinivasa R. Mantena, Emily J. Faivre, Lisa A. Hasvold, George S. Sheppard, Xiaoli Huang, Le Wang, Lance J Bigelow, Stacey Fossey, Steve D. Fidanze, Lloyd T. Lam, Chang H. Park, Sanjay C. Panchal, Warren M. Kati, John J. Nicolette, Richard J. Bellin, Gaurav Mehta, Xiaoyu Lin, Mai H. Bui, Lu Zhang, Paul Hessler, Maricel Torrent, Tamar Uziel, Saul H. Rosenberg, Yu Shen, Kenton L. Longenecker
Publikováno v:
Nature. 578:306-310
Proteins of the bromodomain and extra-terminal (BET) domain family are epigenetic readers that bind acetylated histones through their bromodomains to regulate gene transcription. Dual-bromodomain BET inhibitors (DbBi) that bind with similar affinitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8040bf69aa34810391b9a59139a83026
https://doi.org/10.1038/s41586-020-1930-8
https://doi.org/10.1038/s41586-020-1930-8
Autor:
Prathap Kumar S. Mahalingaiah, Rita Ciurlionis, Bhupinder Bawa, Michael J. Liguori, Terry R. Van Vleet, Binu K. Philip, Kenneth R. Durbin, Ronnie L. Yeager, Srinivasa R. Mantena, Brian P. Enright
Publikováno v:
Pharmacology & Therapeutics. 200:110-125
Antibody-drug conjugates (ADCs) are a promising therapeutic modality for oncology indications. The concept of an ADC platform is to increase the therapeutic index (TI) of chemotherapeutics through more selective delivery of cytotoxic agents to tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275e67fbf57becdf447bb218d67a52af
https://doi.org/10.1016/j.pharmthera.2019.04.008
https://doi.org/10.1016/j.pharmthera.2019.04.008
Autor:
Scott W. Mittelstadt, Eric A. G. Blomme, Mufeng Hu, Srinivasa R. Mantena, Mohan S. Rao, Xin Huang, Terry R. Van Vleet, Rishi R Gupta, Michael J. Liguori
Publikováno v:
Frontiers in Big Data
Most small molecule drugs interact with unintended, often unknown, biological targets and these off-target interactions may lead to both preclinical and clinical toxic events. Undesired off-target interactions are often not detected using current dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ae2ac5bd03530d200ed210bd9ad037
http://europepmc.org/articles/PMC7931946
http://europepmc.org/articles/PMC7931946
Autor:
Laurence O. Whiteley, Lori A. Reed, Sergei S. Makarov, John W. Davis, Andrew D. Burdick, Robert V. Stanton, Ming Zeng, James A. Warneke, Srinivasa R. Mantena, Alexander V. Medvedev, Simone Sciabola, Elena Martsen, Brett D. Hollingshead
Publikováno v:
Nucleic Acids Research
Fully phosphorothioate antisense oligonucleotides (ASOs) with locked nucleic acids (LNAs) improve target affinity, RNase H activation and stability. LNA modified ASOs can cause hepatotoxicity, and this risk is currently not fully understood. In vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85611ff27740a17d07334e364bb34fcd
http://europepmc.org/articles/PMC4005641
http://europepmc.org/articles/PMC4005641
Autor:
Srinivasa R. Mantena, Cynthia M. Rohde, Dean Messing, Sharon A. Sokolowski, John W. Davis, Michael I. Jesson, Karrie A. Brenneman, Shawn P. O'Neil, Lindsay Tomlinson, Christopher G. Leonard, Laurence O. Whiteley, Steven Bailey, Deborah C. Carraher, Walter F. Bobrowski, Zachary S. Stewart, Yutian Zhan, W. Mark Vogel, Kimberly M. Shevlin, Dale L. Morris, Hungyun Lin, Shashi K. Ramaiah, Lauren M. Gauthier
Publikováno v:
Toxicologic Pathology. 42:229-242
Pancreatic toxicity commonly affects the endocrine or exocrine pancreas. However, it can also occur at the endocrine–exocrine interface (EEI), where the capillary network of the islet merges with the capillaries of the surrounding acinar tissue, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb7484afa80d7a23c1ef34fad3d4c11
https://doi.org/10.1177/0192623313508851
https://doi.org/10.1177/0192623313508851
Autor:
Keith F. McDaniel, Johannes E. A. Wolff, Srinivasa R. Mantena, Minh H. Dinh, Marcin Klapczynski, Stormy L. Koeniger, Warren R Kati, Scott W. Mittelstadt
Publikováno v:
Journal of Clinical Oncology. 36:e24207-e24207
e24207Background: Thrombocytopenia is a potential dose-limiting toxicity associated with many oncology agents including BET inhibitors (BETi). Thrombocytopenia in rats closely mirrors clinical dose...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c512f123bb8d0d44eb440bded80ebcd7
https://doi.org/10.1200/jco.2018.36.15_suppl.e24207
https://doi.org/10.1200/jco.2018.36.15_suppl.e24207