Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Srinivasa Prahalada"'
Autor:
Daniel J. Holder, Clay B. Frederick, Adam Smith, Caron L. Cunningham, Xiaorui Yao, Srinivasa Prahalada, Markus Dey, Thomas Forest
Publikováno v:
Endocrinology. 155:783-792
Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor-based incretin therapy intended for the treatment of type 2 diabetes mellitus (T2DM), has not been linked to adverse effects on the pancreas in prospective clinical trials or in nonclinical toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb38b29a3d81601998cfc200fa55fef4
https://doi.org/10.1210/en.2013-1781
https://doi.org/10.1210/en.2013-1781
Autor:
Aleksandr Petrov, Wen Feng, Ann E. Weber, Effie Tozzo, Lisa LaFranco Scheuch, Shiyao Xu, Wei Zhu, Nancy A. Thornberry, Dinko Gonzalez Trotter, Rory J. Rohm, Franklin Liu, Ku Lu, Michelle Bunzel, David E. Kelley, Stacey Conarello, Jinqi Liu, Corin O. Miller, Xiaoda Niu, Huaibing He, Ronald E. Painter, Ying Li, Daniel M. Kemp, Ying Qian, Maria E. Trujillo, Mark D. Erion, Liyang Wang, Iyassu K. Sebhat, Gaochao Zhou, Michael Klimas, Marie A. Holahan, Marc M. Kurtz, George J. Eiermann, Guillermo Fernandez, Bindu Bennet, Juliann Ehrhart, Tesfaye Biftu, Aimie Ogawa, Sandra C. Souza, Cai Li, Srinivasa Prahalada, James A. Milligan, Hong-Ping Guan, Danqing Feng, Robert W. Myers, Douglas Wisniewski, Xiaodong Yang, Daniel Rubins, Hongwu Wang, Margaret van Heek
Publikováno v:
Science (New York, N.Y.). 357(6350)
Hitting a dozen enzymes with one drug The adenosine monophosphate-activated protein kinase (AMPK) controls cellular energy status. AMPK is activated when energy levels fall. This stimulates adenosine triphosphate (ATP)-generating pathways that promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2391508ed314a4efb53e289ff8766448
https://pubmed.ncbi.nlm.nih.gov/28774917
https://pubmed.ncbi.nlm.nih.gov/28774917
Autor:
Takayuki, Tsuchiya, Tasha L, Gray, Nicholas T, Gatto, Thomas, Forest, Sam V, Machotka, Sean P, Troth, Srinivasa, Prahalada
Publikováno v:
Comparative medicine. 64(4)
Epithelioid hemangiosarcoma is a rare malignant endothelial neoplasia with a unique, predominantly epithelioid morphology. A 4-y-old rhesus monkey from our laboratory had multiple neoplastic nodules in a digit, limb skin, hindlimb muscle, and viscera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dced7950b3c2171b2da9e11a645b38ee
https://pubmed.ncbi.nlm.nih.gov/25296017
https://pubmed.ncbi.nlm.nih.gov/25296017
Autor:
M. J. van Zwieten, G. Block, Srinivasa Prahalada, Chao-Min Hoe, M. Cahill, L. Handt, G. DeBurlet
Publikováno v:
Hormone and Metabolic Research. 31:133-137
Elevation in circulating GH levels results in a dose-related increase in serum insulin-like growth factor-1 (IGF-1) levels in dogs. However, it is not known whether elevations in systemic IGF-1 and GH levels contribute to the cerebrospinal fluid (CSF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb22ef52f49a2ba00ab76eee79efda62
https://doi.org/10.1055/s-2007-978710
https://doi.org/10.1055/s-2007-978710
Autor:
Kevin P. Keenan, D. Heggan, Chao-Min Hoe, M.J. van Zwieten, Charles Berman, M.A. Cukierski, Linda Rhodes, S.J. Grossman, Srinivasa Prahalada
Publikováno v:
The Prostate. 35:157-164
BACKGROUND In rats, the prostate is divided into three distinct lobes, and the lobes are dependent on androgens [testosterone (T) and dihydrotestosterone (DHT)] as trophic hormones. However, the reasons for the difference in the incidence of prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9a983e6265ee8de1b145a520aef8cf4
https://doi.org/10.1002/(sici)1097-0045(19980515)35:3<157::aid-pros1>3.0.co
https://doi.org/10.1002/(sici)1097-0045(19980515)35:3<157::aid-pros1>3.0.co
Morphological Changes in the Pituitary Gland of Dogs Chronically Exposed to Exogenous Growth Hormone
Autor:
Lea G. Stabinski, Matthew J. van Zwieten, Sylvain Molon-Noblot, Chennekatu P. Peter, Pierre Duprat, Srinivasa Prahalada, Philippe Laroque, Chao-Min Hoe
Publikováno v:
Toxicologic Pathology. 26:201-206
Growth hormone (GH) synthesis and release from the pituitary is regulated by hypothalamic releasing hormone, insulin-like growth factor-1 (IGF-1). and somatostatin. However, the potential effects of pharmacological doses of exogenous GH on the pituit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c33989fb20d4b23339a7ee07853d0b0b
https://doi.org/10.1177/019262339802600202
https://doi.org/10.1177/019262339802600202
Autor:
Lea G. Stabinski, Philippe Laroque, Sylvain Molon-Noblot, Pierre Duprat, Srinivasa Prahalada, Matthew J. van Zwieten, Chennekatu P. Peter, Chao-Min Hoe
Publikováno v:
Toxicologic Pathology. 26:207-212
Administration of growth hormone (GH) results in increased body weight gain in dogs. Increased body weight gain is believed to be a result of the trophic effect of GH on the musculoskeletal system. However, edema is one of the side effects described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d27d37f645c6356c17dbbb7bf7fbe19
https://doi.org/10.1177/019262339802600203
https://doi.org/10.1177/019262339802600203
Autor:
Howard Y. Chen, Chennekatu P. Peter, Lea G. Stabinski, Dan Holder, Darryl H. Patrick, Srinivasa Prahalada, Richard E. Morrissey, Matthew J. van Zwieten, Georges De Burlet
Publikováno v:
Toxicologic Pathology. 26:185-200
The purpose of this study was to evaluate the pharmacological and toxicological effects of exogenous GH administration in normal adult dogs. Because porcine GH (pGH) is structurally identical to canine GH, pGH was selected for a 14-wk study in dogs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5729b854cb405b9aa4c573f3fefd35ff
https://doi.org/10.1177/019262339802600201
https://doi.org/10.1177/019262339802600201
Autor:
Chennekatu P. Peter, M.J. van Zwieten, Srinivasa Prahalada, Philippe Laroque, S M Cohen, Pierre Duprat, Keith A. Soper, S Molon-Noblot
Publikováno v:
The Prostate. 27:121-128
The objective of this study was to determine the effects of 2 different 5-alpha reductase inhibitors (finasteride and MK-0434) on the glandular and stromal compartments of hyperplastic canine prostates. In this study, dogs received 1 of the 2 compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d88f5c4d1156c6c089e8c2622cfc148
https://doi.org/10.1002/pros.2990270302
https://doi.org/10.1002/pros.2990270302
Autor:
Sheila M. Cohen, G Harris, J G Jacobs, W K Tanaka, Gary H. Rasmusson, T M Nett, Jeffrey G. Werrmann, P. F. Malatesta, Srinivasa Prahalada
Publikováno v:
The Prostate. 26:55-71
Four new azasteroid inhibitors of steroid 5 alpha-reductase were compared to the benchmark compound finasteride, each at a dose level of 1 mg/kg/day, as well to placebo and to castration, in seven groups of mature male beagle dogs with enlarged prost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe170e9ccd86ec874e441fdeaa76c7ec
https://doi.org/10.1002/pros.2990260202
https://doi.org/10.1002/pros.2990260202