Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Srinivasa P S, Rao"'
Autor:
Natasha S. Hochberg, Srinivasa P. S. Rao, Gerhild Angyalosi, Xiaojun Zhao, Leticia Carballo, Caroline Demacq, Sofia Braud-Perez, Daniela Wieser, JP Casas, John Millholland, Debby Ngo
Publikováno v:
Frontiers in Parasitology, Vol 2 (2023)
Novel therapies for chronic indeterminate Chagas disease (CICD) are needed, but trials are limited by the absence of tests to detect infection and early treatment efficacy. This perspective highlights the shortfalls and strengths of polymerase chain
Externí odkaz:
https://doaj.org/article/c24db153dd35483e96c775d1ff263e9e
Autor:
Manuel Saldivia, Adam J. M. Wollman, Juliana B. T. Carnielli, Nathaniel G. Jones, Mark C. Leake, Christopher Bower-Lepts, Srinivasa P. S. Rao, Jeremy C. Mottram
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
In eukaryotic cells, kinetochores are large protein complexes that link chromosomes to dynamic microtubule tips, ensuring proper segregation and genomic stability during cell division. Several proteins tightly coordinate kinetochore functions, includ
Externí odkaz:
https://doaj.org/article/86905287e15d4286a26051507d71d700
Autor:
Dennis C. Koester, Vanessa M. Marx, Sarah Williams, Jan Jiricek, Maxime Dauphinais, Olivier René, Sarah L. Miller, Lei Zhang, Debjani Patra, Yen-Liang Chen, Harry Cheung, Jonathan Gable, Suresh B. Lakshminarayana, Colin Osborne, Jean-Rene Galarneau, Upendra Kulkarni, Wendy Richmond, Angela Bretz, Linda Xiao, Frantisek Supek, Christian Wiesmann, Srinivas Honnappa, Celine Be, Pascal Mäser, Marcel Kaiser, Ryan Ritchie, Michael P. Barrett, Thierry T. Diagana, Christopher Sarko, Srinivasa P. S. Rao
Publikováno v:
Journal of Medicinal Chemistry. 65:11776-11787
Human African Trypanosomiasis (HAT) is a vector-borne disease caused by kinetoplastid parasites of the Trypanosoma genus. The disease proceeds in two stages, with a hemolymphatic blood stage and a meningo-encephalic brain stage. In the latter stage,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08e0300ccf8a00a7016873258c0e648
https://doi.org/10.1021/acs.jmedchem.2c00791
https://doi.org/10.1021/acs.jmedchem.2c00791
Autor:
Srinivasa P S Rao, Suresh B Lakshminarayana, Jan Jiricek, Marcel Kaiser, Ryan Ritchie, Elmarie Myburgh, Frantisek Supek, Tove Tuntland, Advait Nagle, Valentina Molteni, Pascal Mäser, Jeremy C Mottram, Michael P Barrett, Thierry T Diagana
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 28 (2020)
Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs. Previously, we reported the discovery of the
Externí odkaz:
https://doaj.org/article/e5e1e471c0c746d79f9d7063a4a2f672
Autor:
Emily A. Dickie, Federica Giordani, Matthew K. Gould, Pascal Mäser, Christian Burri, Jeremy C. Mottram, Srinivasa P. S. Rao, Michael P. Barrett
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 29 (2020)
The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs aiming to contain the disease had ground to a halt, given previous success
Externí odkaz:
https://doaj.org/article/fcec70764b7842eda3b0f5326af38879
Autor:
Ujjini H. Manjunatha, Christel Brunschwig, Mathew Njoroge, Srinivasa P. S. Rao, Nina Lawrence, Dale Taylor, Rudolf Müller, Kelly Chibale, Paul M. Njaria, Renier van der Westhuyzen, Vinayak Singh, Leslie J. Street, Amanda Mabhula, Atica Moosa, Digby F. Warner, Denis Ngumbu Muhunga, Paul W. Smith
Publikováno v:
Journal of Medicinal Chemistry. 64:9444-9457
Screening of a library of small polar molecules against Mycobacterium tuberculosis (Mtb) led to the identification of a potent benzoheterocyclic oxime carbamate hit series. This series was subjected to medicinal chemistry progression underpinned by s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f22b2b0b4cd9366307e089958a09622f
https://doi.org/10.1021/acs.jmedchem.1c00707
https://doi.org/10.1021/acs.jmedchem.1c00707
Autor:
Glen Spraggon, Smith Jeffrey M, Chianelli Donatella, Advait Nagle, Christian Wiesmann, Xiaodong Liu, Yongping Xie, Richard J. Sciotti, Todd Groessl, Kevin Johnson, Xianzhong Liu, Celine Be, Christopher Thompson, Yin H. Lai, Jan Jiricek, Patrick J Rudewicz, Brandon S. Pybus, Casey J. N. Mathison, Valentina Molteni, Honnappa Srinivas, Richard Glynne, Jaime Ballard, Agnes Biggart, Diana Caridha, Andreas Hein, Ashley Mitchell Berman, Mu-Yun Gao, Lauren C. Davis, Michael Shapiro, Michael Gibney, Yen Liang Chen, Vince Yeh, Fabian K. Eggimann, Badry Bursulaya, Mara Kreishman-Deitrick, Lerario Isabelle K, Fang Liang, Shilpi Khare, Wendy Richmond, Srinivasa P. S. Rao, Frantisek Supek, Tove Tuntland, Alexandre Luneau
Publikováno v:
Journal of Medicinal Chemistry
Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of GNF6702, a selective inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37584f6654d3dc34b0710ef1ed444634
https://doi.org/10.1021/acs.jmedchem.0c00499
https://doi.org/10.1021/acs.jmedchem.0c00499
Autor:
Xiaolei Ma, Christopher Bower-Lepts, Jeremy C. Mottram, Frantisek Supek, Eric Fang, Elmarie Myburgh, Marcel Kaiser, Manuel Saldivia, Michael P. Barrett, Daniel Paape, Thierry T. Diagana, Yen Liang Chen, Suresh B Lakhsminarayana, Jan Jiricek, Ryan Ritchie, Elizabeth Ornelas, Richard McCulloch, Srinivasa P. S. Rao, Hazel X. Y. Koh, Debjani Patra, Juliana B.T. Carnielli, Sarah Williams, Elaine Brown
Publikováno v:
Nature microbiology
The kinetochore is a macromolecular structure that assembles on the centromeres of chromosomes and provides the major attachment point for spindle microtubules during mitosis. In Trypanosoma brucei the proteins that make up the kinetochore are highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ef2bf812ae3c12aa779256b42cc13c
http://europepmc.org/articles/PMC7610364
http://europepmc.org/articles/PMC7610364
Autor:
Michal Pikusa, Olivier René, Sarah Williams, Yen-Liang Chen, Eric Martin, William J. Godinez, Srinivasa P S Rao, W. Armand Guiguemde, Florian Nigsch
Designing novel molecules with targeted biological activities and optimized physicochemical properties is a challenging endeavor in drug discovery. Recent developments in artificial intelligence have enhanced the early steps of de novo drug design an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1fae6e9e95846835886d45388f83b83
https://doi.org/10.1101/2021.12.10.472084
https://doi.org/10.1101/2021.12.10.472084
Autor:
Renier, van der Westhuyzen, Amanda, Mabhula, Paul M, Njaria, Rudolf, Müller, Denis, Ngumbu Muhunga, Dale, Taylor, Nina, Lawrence, Mathew, Njoroge, Christel, Brunschwig, Atica, Moosa, Vinayak, Singh, Srinivasa P S, Rao, Ujjini H, Manjunatha, Paul W, Smith, Digby F, Warner, Leslie J, Street, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(13)
Screening of a library of small polar molecules against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03d111d78c2e649bf21f94024eb5cf31
https://pubmed.ncbi.nlm.nih.gov/34138573
https://pubmed.ncbi.nlm.nih.gov/34138573