Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Srinivas Somarowthu"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Long non-coding RNAs (lncRNAs) play key roles in cellular pathways and disease progression, yet their molecular mechanisms remain largely understudied. The lncRNA lncTCF7 has been shown to promote tumor progression by recruiting the SWI/SNF
Externí odkaz:
https://doaj.org/article/0a469dba2fce421cb8a37bcc13af8265
Autor:
Jacopo Manigrasso, Isabel Chillón, Vito Genna, Pietro Vidossich, Srinivas Somarowthu, Anna Marie Pyle, Marco De Vivo, Marco Marcia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Group II introns are self-splicing ribozymes. Here, the authors employ enzymatic assay, X-ray crystallography and molecular dynamics simulations to show that protonation of the group II intron catalytic triad plays an important role for the transitio
Externí odkaz:
https://doaj.org/article/a0ddbc7f74af45d393f62a1504d55452
Autor:
Jacopo Manigrasso, Isabel Chillón, Vito Genna, Pietro Vidossich, Srinivas Somarowthu, Anna Marie Pyle, Marco De Vivo, Marco Marcia
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/169771c301a5493aa8fd7ddea74164b6
Publikováno v:
Journal of Medical Virology. 95
Hepatitis B Virus (HBV) infections remain a major global health burden with an estimated 296 million people living with a chronic infection and 884,000 HBV-related deaths annually. Notably, patients with a chronic hepatitis B (CHB) infection are at a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501be0754774e86b046295e0a6b18a47
https://doi.org/10.1002/jmv.28058
https://doi.org/10.1002/jmv.28058
Autor:
Mihyun Oh, Srinivas Somarowthu
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f397b2bba2be30c9d106d28f18c994d
https://doi.org/10.1096/fasebj.2022.36.s1.l7756
https://doi.org/10.1096/fasebj.2022.36.s1.l7756
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2372
Long noncoding RNAs (lncRNAs) are now accepted as key players in diverse cellular functions, yet the structure-function relationships of these novel RNAs remain mostly unknown. Homogenous purification of lncRNAs is a necessary first-step for downstre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30d1620b71ce84e6bdf3e1c7a8b8a02d
https://pubmed.ncbi.nlm.nih.gov/34417746
https://pubmed.ncbi.nlm.nih.gov/34417746
Publikováno v:
Journal of Molecular Biology. 431:1592-1603
The existence of evolutionary conservation in base pairing is strong evidence for functional elements of RNA structure, although available tools for rigorous identification of structural conservation are limited. R-scape is a recently developed progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1092ffacec17f066258c45bb6070622
https://doi.org/10.1016/j.jmb.2019.03.012
https://doi.org/10.1016/j.jmb.2019.03.012
Publikováno v:
Long Non-Coding RNAs ISBN: 9781071616963
Long noncoding RNAs (lncRNAs) are now accepted as key players in diverse cellular functions, yet the structure-function relationships of these novel RNAs remain mostly unknown. Homogenous purification of lncRNAs is a necessary first-step for downstre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::704b3bfb442a9ccd1e695c7e0a0bc375
https://doi.org/10.1007/978-1-0716-1697-0_10
https://doi.org/10.1007/978-1-0716-1697-0_10
Autor:
Vito Genna, Jacopo Manigrasso, Srinivas Somarowthu, Isabel Chillón, Anna Marie Pyle, Marco De Vivo, Pietro Vidossich, Marco Marcia
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Group II introns are ubiquitous self-splicing ribozymes and retrotransposable elements evolutionarily and chemically related to the eukaryotic spliceosome, with potential applications as gene-editing tools. Recent biochemical and structural data have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d5929a739e1c3d83f5313d7779d062
https://doi.org/10.1038/s41467-020-16741-4
https://doi.org/10.1038/s41467-020-16741-4
Autor:
Andrey G. Baranovskiy, Tahir H. Tahirov, Farid A. Kadyrov, Lyudmila Y. Kadyrova, Alexander V. Mazin, Srinivas Somarowthu, Olga M. Mazina
Publikováno v:
J Biol Chem
Replication protein A (RPA), a major eukaryotic ssDNA-binding protein, is essential for all metabolic processes that involve ssDNA, including DNA replication, repair, and damage signaling. To perform its functions, RPA binds ssDNA tightly. In contras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef37093b994af6fd015b77ffb6ce690
https://doi.org/10.1101/2020.02.11.943977
https://doi.org/10.1101/2020.02.11.943977