Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Srinivas Shankara"'
Autor:
Olivia Castellini-Pérez, Elena Povedano, Guillermo Barturen, Manuel Martínez-Bueno, Andrii Iakovliev, Martin Kerick, Raúl López-Domínguez, Concepción Marañón, Javier Martín, Esteban Ballestar, PRECISEADS Clinical Consortium, PRECISEADS Flow Cytometry Study Group, María Orietta Borghi, Weiliang Qiu, Cheng Zhu, Srinivas Shankara, Athina Spiliopoulou, Emanuele de Rinaldis, Elena Carnero-Montoro, Marta E. Alarcón-Riquelme
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract The heterogeneity of systemic lupus erythematosus (SLE) can be explained by epigenetic alterations that disrupt transcriptional programs mediating environmental and genetic risk. This study evaluated the epigenetic contribution to SLE hetero
Externí odkaz:
https://doaj.org/article/142e1626384c4d3d9b97c0f758239917
Autor:
Hongwei Han, Sheila Cummings, Kai-Ting C. Shade, Jennifer Johnson, George Qian, Joseph Gans, Srinivas Shankara, Javier Escobedo, Erik Zarazinski, Renee Bodinizzo, Dinesh Bangari, Paul Bryce, Alexandra Hicks
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Ocular surface diseases, including conjunctivitis, are recognized as common comorbidities in atopic dermatitis (AD) and occur at an increased frequency in patients with AD treated with biologics targeting IL-4 receptor α (IL-4Rα) or IL-13. However,
Externí odkaz:
https://doaj.org/article/39c1aafcc7e24ff0baf544fbefe43bba
Autor:
Sambasiva P Rao, Jose Sancho, Juanita Campos-Rivera, Paula M Boutin, Peter B Severy, Timothy Weeden, Srinivas Shankara, Bruce L Roberts, Johanne M Kaplan
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39416 (2012)
Alemtuzumab is a monoclonal antibody that targets cell surface CD52 and is effective in depleting lymphocytes by cytolytic effects in vivo. Although the cytolytic effects of alemtuzumab are dependent on the density of CD52 antigen on cells, there is
Externí odkaz:
https://doaj.org/article/5deecdc8b16d435480f9c85d5a9e76d0
Autor:
Nora Rӧsch, Christian Barro, Zuzanna Michalak, Jens Kuhle, Carina Kaiser, Colin Mitchell, Aleksandra Maceski, Maria Pia Sormani, Jean Godin, Ludwig Kappos, David Leppert, Luke Chung, Alan Jacobs, Srinivas Shankara, Pascal Benkert, Evis Havari, Nadia Daizadeh, Tarek A Samad
Publikováno v:
Multiple Sclerosis Journal. 28:573-582
Background: Alemtuzumab efficacy and safety was demonstrated in CARE-MS I and extension studies (CAMMS03409; TOPAZ). Objective: Evaluate serum neurofilament light chain (sNfL) in CARE-MS I patients and highly active disease (HAD) subgroup, over 7 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344820f55c4a23065e16311d792d37cc
https://doi.org/10.1177/13524585211032348
https://doi.org/10.1177/13524585211032348
Autor:
Hongwei Han, Sheila Cummings, Kai-Ting C Shade, Jennifer Johnson, George Qian, Joseph Gans, Srinivas Shankara, Javier Escobedo, Erik Zarazinski, Renee Bodinizzo, Paul Bryce, Alexandra Hicks
Ocular surface diseases, including conjunctivitis, are recognized as a common comorbidity in atopic dermatitis (AD) and also occur at an increased frequency in AD patients treated with biologics targeting interleukin-4 receptor alpha (IL-4Ra) or IL-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::685bcf3da410d579bd342bc1915d28a6
https://doi.org/10.21203/rs.3.rs-1669593/v1
https://doi.org/10.21203/rs.3.rs-1669593/v1
Autor:
Sean K. Ryan, Matija Zelic, Yingnan Han, Erin Teeple, Luoman Chen, Mahdiar Sadeghi, Srinivas Shankara, Lilu Guo, Cong Li, Fabrizio Pontarelli, Elizabeth H. Jensen, Ashley L. Comer, Dinesh Kumar, Mindy Zhang, Joseph Gans, Bailin Zhang, Jonathan D. Proto, Jacqueline Saleh, James C. Dodge, Virginia Savova, Deepak Rajpal, Dimitry Ofengeim, Timothy R. Hammond
Publikováno v:
Nature neuroscience.
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson’s disease (PD). Iron-loaded microglia are frequently found in affected brain regions, but how iron accumulation influences microglia physiology and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2a7cae2fcd634b09277536453a3fad
https://pubmed.ncbi.nlm.nih.gov/36536241
https://pubmed.ncbi.nlm.nih.gov/36536241
Autor:
Matija Zelic, Srinivas Shankara, Lilu Guo, Erin Teeple, Jonathan Proto, Deepak K. Rajpal, Joseph Gans, Timothy R. Hammond, Mindy Zhang, Elizabeth H. Jensen, Dimitry Ofengeim, Yingnan Han, Luoman Chen, Dinesh Kumar, Mahdiar Sadeghi, Sean K. Ryan, Cong Li, Fabrizio Pontarelli, Jacqueline Saleh, James C. Dodge, Bailin Zhang
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson’s Disease (PD), Amyotrophic Lateral Sclerosis (ALS), and Multiple Sclerosis (MS). One prominent feature of affected brain regions are iron-loaded mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76f8cefbd8e4fabc09cc7277f0f8500b
https://doi.org/10.1101/2021.11.02.466996
https://doi.org/10.1101/2021.11.02.466996
Polyomavirus Middle-Sized Tumor Antigen Modulates c-Jun Phosphorylation and Transcriptional Activity
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1994 Oct 01. 91(21), 10064-10068.
Externí odkaz:
https://www.jstor.org/stable/2365763
Autor:
Yingnan Han, Stephen L. Madden, Katherine W. Klinger, Dongyu Liu, Cheng Zhu, Erin Teeple, Francesca Frau, Srinivas Shankara, Deepak Rajpal, S. Pablo Sardi, Mahdiar Sadeghi, Clarence Wang, Dinesh Kumar, FinnGen
SUMMARYParkinson’s Disease (PD) is the second most common and fastest-growing neurological disorder. Polygenic Risk Scores (PRS) using hundreds to thousands of PD-associated variants support polygenic heritability. Here, for the first time, we appl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c8db62596a9ef5161243d0e2b239629
https://doi.org/10.1101/2020.10.16.20212944
https://doi.org/10.1101/2020.10.16.20212944
Autor:
Srinivas Shankara, Stephen L. Madden, Erin Teeple, Khushboo Jindal, S. Pablo Sardi, Beril Kiragasi, Can Kayatekin, Siddharth Annaldasula, Dinesh Kumar, Ann Byrne, Klinger Kw, Lilly Chai, Mahdiar Sadeghi
Alpha-synuclein (SNCA) aggregates are pathological hallmarks of synucleinopathies, neurodegenerative disorders including Parkinson’s Disease (PD) and Lewy Body Dementia (LBD). Functional networks are not yet well-characterized for SNCA by CNS cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41970ad3c85a1d7016b02ad3fe246330
https://doi.org/10.1101/2020.06.05.137166
https://doi.org/10.1101/2020.06.05.137166