Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Srinivas N. Pentyala"'
Autor:
Amith Anugu, Rebecca Monastero, Sahana Pentyala, Vamiq M. Mustahsan, Yanming Cai, Jason Rosenfeld, David E. Komatsu, James Penna, Lawrence Hurst, Srinivas N. Pentyala
Publikováno v:
Methods and Protocols, Vol 4, Iss 4, p 69 (2021)
Gout is an inflammatory arthritis, which causes intense, acute pain due to the buildup of uric acid crystals in synovial fluid. The gold standard for gout diagnosis consists of synovial fluid analysis by polarized light microscopy, which is costly, t
Externí odkaz:
https://doaj.org/article/73093d9839f6468cbcae6695d4d94d0c
Cutting edge technologies can propel a simple finding in basic science to a concept that can be of immense value to the society. While applying novel techniques to unravel the mysteries of biological processes, an offshoot of applied branch emerged.
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 345:213-221
Long term amiodarone (AM) therapy has been associated with several side effects including neurotoxicity. Since AM alters Ca2+ regulated events, we have studied its effects on the compartmentation of free Ca2+ in the synaptosomes as an attempt to unde
Autor:
Joseph A. Cameron, Prasada Rao S. Kodavanti, Prabhakara R. Yallapragada, Durisala Desaiah, Srinivas N. Pentyala
Publikováno v:
Drug Development Research. 26:49-59
Cationic amphiphilic drugs such as imipramine, chlorimipramine, chlorpromazine, chlorphentermine, and chloroquine have been shown to cause myocardial toxicity including arrhythmia, cardiomyopathy, and myocarditis. Since calcium transport by sarcoplas
Publikováno v:
Journal of Applied Toxicology. 11:403-409
Triorganotins have been reported to affect heme metabolism as well as the cardiovascular system. Our recent studies indicated that these organotins inhibit cardiac sarcoplasmic reticulum Ca(2+)-transport and cAMP-stimulated phosphorylation of specifi
Publikováno v:
American journal of physiology. Cell physiology. 287(6)
The mechanism of phospholipase (PLC)-δ activation by G protein-coupled receptor agonists was examined in rabbit gastric smooth muscle. Ca2+stimulated an eightfold increase in PLC-δ1 activity in permeabilized muscle cells. Treatment of dispersed or
Publikováno v:
Cellular signalling. 6(5)
Carbon tetrachloride (CCl 4 ) is a highly toxic industrial solvent with pronounced effects of the liver and brain. CCl 4 is enzymatically cleaved to produce free radicals which attack membrane components, including proteins. Earlier indicated that CC
Publikováno v:
Pharmacologytoxicology. 75(1)
Receptor-mediated phosphoinositide signaling pathway which generates a variety of second messengers is regulated by intracellular free Ca2+ concentrations. Since toxic metal cations like Pb2+ are known to alter Ca(2+)-dependent processes, the present