Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Srinivas Kantham"'
Autor:
Claudia Günther, Mano Mathew, Sebastian Zundler, Anja A. Kühl, Markus F. Neurath, Christina Heichler, Miguel Gonzalez Acera, Jay Paquette, Moritz Leppkes, Kevan Jacobson, Fabrizio Mascia, Stefan Wirtz, Jay V. Patankar, Yuqiang Yu, Christoph Becker, Srinivas Kantham, Kristina Scheibe, Robert N. Young, Barbara Ruder, Tanja M. Müller, Mousumi Mahapatro, Clemens Neufert, Raja Atreya, Wei Li
Publikováno v:
Nature Cell Biology. 23:796-807
Inflammatory bowel diseases present with elevated levels of intestinal epithelial cell (IEC) death, which compromises the gut barrier, activating immune cells and triggering more IEC death. The endogenous signals that prevent IEC death and break this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c62b99dc56468a372a5b6f3f4d5f0ed
https://doi.org/10.1038/s41556-021-00708-8
https://doi.org/10.1038/s41556-021-00708-8
Autor:
Gawain McColl, Stephen Chan, Marie-Odile Parat, Suresh Kumar Veliyath, Zeyad D. Nassar, Xavier Brazzolotto, Israel Silman, Joel L. Sussman, Eugenio de la Mora, Satish N. Dighe, Jared A. Miles, B. Yogi Sreenivas, Martin Weik, Ross P. McGeary, Benjamin P. Ross, Srinivas Kantham
Publikováno v:
Communications Chemistry, Vol 2, Iss 1, Pp 1-14 (2019)
The development of polyphenols as drugs for Alzheimer’s disease (AD) is thwarted by their meagre brain availability due to instability and poor druglikeness. Here we describe the successful development of stable, druglike polyphenolic analogues of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cd4ae5ed5b5bda78c7c14c1d7504d4
http://link.springer.com/article/10.1038/s42004-019-0133-4
http://link.springer.com/article/10.1038/s42004-019-0133-4
Autor:
Michael Glogauer, Robert N. Young, Gang Chen, Marion Thévenin, Srinivas Kantham, Chunxiang Sun
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] A series of bone-targeting EP4 receptor agonist conjugate prodrugs were prepared wherein a potent EP4 receptor agonist was bound to a biologically inactive, bisphosphonate-based bone-targeting moiety. Singly and doubly radiolabeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f1897a92b0ff7740b94697fe7a8921
http://summit.sfu.ca/item/21052
http://summit.sfu.ca/item/21052
Autor:
Suresh Kumar Veliyath, Girdhar Singh Deora, Jared A. Miles, Samira Khabbazi, Gawain McColl, Marie-Odile Parat, Benjamin P. Ross, Srinivas Kantham, Stephen Chan, Satish N. Dighe
Publikováno v:
ACS Chemical Neuroscience. 8:1901-1912
The biphenyl neolignan honokiol is a neuroprotectant which has been proposed as a treatment for central nervous system disorders such as Alzheimer’s disease (AD). The death of cholinergic neurons in AD is attributed to multiple factors, including a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2692a968a72d2a7c3f697793e91c516
https://doi.org/10.1021/acschemneuro.7b00071
https://doi.org/10.1021/acschemneuro.7b00071
Autor:
Venkatesan Moorthy Rao, P. Nicholas Shaw, Srinivas Kantham, Stephen Chan, Manoj Kumar Palanivelu, Ross P. McGeary, Benjamin P. Ross, Hoang L. Pham
Publikováno v:
Food Chemistry. 199:185-194
Various food constituents have been proposed as disease-modifying agents for Alzheimer's disease (AD), due to epidemiological evidence of their beneficial effects, and for their ability to ameliorate factors linked to AD pathogenesis, namely by: chel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b0bd1ea7d1edbc11cc8b55229bf9e2
https://doi.org/10.1016/j.foodchem.2015.11.118
https://doi.org/10.1016/j.foodchem.2015.11.118
Autor:
Ross P. McGeary, Girdhar Singh Deora, Satish N. Dighe, Stephen Chan, Benjamin P. Ross, Marie-Odile Parat, Suresh Kumar Veliyath, Gawain McColl, Srinivas Kantham
Publikováno v:
ACS chemical neuroscience. 8(12)
We report the synthesis and pharmacological investigation of analogs of the endogenous molecule kynurenic acid (KYNA) as multifunctional agents for the treatment of Alzheimer’s disease (AD). Synthesized KYNA analogs were tested for their N-methyl-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486a9605ce88ec234e9a92973f332cf0
https://pubmed.ncbi.nlm.nih.gov/28825789
https://pubmed.ncbi.nlm.nih.gov/28825789
Autor:
Srinivas, Kantham, Stephen, Chan, Gawain, McColl, Jared A, Miles, Suresh Kumar, Veliyath, Girdhar Singh, Deora, Satish N, Dighe, Samira, Khabbazi, Marie-Odile, Parat, Benjamin P, Ross
Publikováno v:
ACS chemical neuroscience. 8(9)
The biphenyl neolignan honokiol is a neuroprotectant which has been proposed as a treatment for central nervous system disorders such as Alzheimer's disease (AD). The death of cholinergic neurons in AD is attributed to multiple factors, including acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0eac49ac692b287b84b50341682c269e
https://pubmed.ncbi.nlm.nih.gov/28650631
https://pubmed.ncbi.nlm.nih.gov/28650631
Autor:
Stephen, Chan, Srinivas, Kantham, Venkatesan M, Rao, Manoj Kumar, Palanivelu, Hoang L, Pham, P Nicholas, Shaw, Ross P, McGeary, Benjamin P, Ross
Publikováno v:
Food chemistry. 199
Various food constituents have been proposed as disease-modifying agents for Alzheimer's disease (AD), due to epidemiological evidence of their beneficial effects, and for their ability to ameliorate factors linked to AD pathogenesis, namely by: chel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e226b1c11e081430e99ae496229adb5f
https://pubmed.ncbi.nlm.nih.gov/26775960
https://pubmed.ncbi.nlm.nih.gov/26775960