Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Srinivas Jayanthi"'
1
Akademický článek
Effect of extension of the heparin binding pocket on the structure, stability, and cell proliferation activity of the human acidic fibroblast growth factor
Autor: Julie Eberle Davis, Ravi Kumar Gundampati, Srinivas Jayanthi, Joshua Anderson, Abigail Pickhardt, Bhanu prasanth Koppolu, David A. Zaharoff, Thallapuranam Krishnaswamy Suresh Kumar
Publikováno v: Biochemistry and Biophysics Reports, Vol 13, Iss , Pp 45-57 (2018)
Acidic human fibroblast growth factor (hFGF1) plays a key role in cell growth and proliferation. Activation of the cell surface FGF receptor is believed to involve the glycosaminoglycan, heparin. However, the exact role of heparin is a subject of con
Externí odkaz: https://doaj.org/article/8e6c0f7814af4fd0a6fcb6fb12ad3479
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2
Akademický článek
Modulation of Interleukin-12 activity in the presence of heparin
Autor: Srinivas Jayanthi, Bhanu prasanth Koppolu, Khue G. Nguyen, Sean G. Smith, Barbara K. Felber, Thallapuranam Krishnaswamy Suresh Kumar, David A. Zaharoff
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Glycosaminoglycans (GAGs), especially heparin and heparan sulfate (HS), modulate the functions of numerous cytokines. The aims of this multidisciplinary research were to characterize heparin binding to interleukin-12 (IL-12) and determine th
Externí odkaz: https://doaj.org/article/e144fa0271714f01b788c20adf60ba9f
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3
Biomarkers improves prognostic and mortality prediction in pneumonia
Autor: N. Meenakshi, D. Danis Vijay, Srinivas Jayanthi
Publikováno v: Indian Journal of Microbiology Research. 5:430-435
Pneumonia exhibits mortality rates, between 20% and 50% in severe cases. Biomarkers are useful tools for antibiotic therapy modifications as well as diagnosis, prognosis and follow-up treatment of pneumonia. This review presents the biological and cl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc7b603be0e51098cad4222411c2f753
https://doi.org/10.18231/2394-5478.2018.0089
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4
Multiplex PCR based detection of mecA, mecC and PVL gene in analysis of prevalence, circulation, transmission of MSSA/MRSA strains in a tertiary care hospital
Autor: Srinivas Jayanthi, J. Perumal, S. H. Shifa Meharaj, A. Sujhithra, D. Danisvijay
Publikováno v: IP International Journal of Medical Microbiology and Tropical Diseases. 5:155-159
Introduction: Staphylococcus aureus a Gram positive cocci causes major and minor infections in humans. It is the most important pathogen causing Hospital acquired and community-acquired (CA) infections. The commonest being the Methicillin resistant S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db5d0715fe0a5306d6825521cfb9ca48
https://doi.org/10.18231/j.ijmmtd.2019.034
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5
Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity
Autor: Francis B. Gillam, Jared J. Hopkins, David A. Zaharoff, Suresh Kumar Thallapuranam, Rashmi Jalah, Barbara K. Felber, Jian Liu, Ravi Kumar Gundampati, Guy R. Pilkington, Khue G. Nguyen, Srinivas Jayanthi, Guowei Su, Jenifer Bear
Publikováno v: Journal of Biological Chemistry. 294:4412-4424
Human interleukin-12 (hIL-12) is a heparin-binding cytokine whose activity was previously shown to be enhanced by heparin and other sulfated glycosaminoglycans. The current study investigated the mechanisms by which heparin increases hIL-12 activity.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc86b895034a47a50d0b03cd9b0f60d1
https://doi.org/10.1074/jbc.ra118.006193
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7
Simplification of the purification of heat stable recombinant low molecular weight proteins and peptides from GST-fusion products
Autor: Thallapuranam Krishnaswamy Suresh Kumar, Beatrice Sakhel, Djamali Muhoza, Srinivas Jayanthi, Patience Okoto, Paul D. Adams
Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1172
The synthesis and purification of peptides of importance in the fields of research and medicine continue to be a challenging task. Chemical synthesis of oligopeptides, especially those greater than 25 amino acids, is cost prohibitive. On the other ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf48fe075cdf1052e12e5affa16fbfc
https://pubmed.ncbi.nlm.nih.gov/33773335
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