Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Srinivas Gonti"'
Autor:
Fabiana Freire Mendes de Oliveira, Sireesha Mamillapalli, Srinivas Gonti, Robert N. Brey, Han Li, Jarad Schiffer, Arturo Casadevall, James G. Bann
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
ABSTRACT Protective antigen (PA) is a component of anthrax toxin that can elicit toxin-neutralizing antibody responses. PA is also the major antigen in the current vaccine to prevent anthrax, but stability problems with recombinant proteins have comp
Externí odkaz:
https://doaj.org/article/c5b08a3442284ba9b28cd6995fad9269
Autor:
Harry Scott, Wei Huang, Kiran Andra, Sireesha Mamillapalli, Srinivas Gonti, Alexander Day, Kaiming Zhang, Nurjahan Mehzabeen, Kevin P. Battaile, Anjali Raju, Scott Lovell, James G. Bann, Derek J. Taylor
Publikováno v:
Journal of Molecular Biology. 434:167548
The tripartite protein complex produced by anthrax bacteria (Bacillus anthracis) is a member of the AB family of β-barrel pore-forming toxins. The protective antigen (PA) component forms an oligomeric prepore that assembles on the host cell surface
Publikováno v:
Biochemistry
The anthrax toxin protective antigen (PA), the membrane binding and pore-forming component of the anthrax toxin, was studied using (19)F NMR. We site-specifically labeled PA with p-fluorophenylalanine (pF-Phe) at Phe427, a critically important residu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447c4b841322f2a5b6128bdc2c8c8de3
https://europepmc.org/articles/PMC8991541/
https://europepmc.org/articles/PMC8991541/
Autor:
Kevin P. Battaile, Kaiming Zhang, Scott Lovell, Wei Huang, Derek J. Taylor, Srinivas Gonti, James G. Bann, N. Mehzabeen, Alexander Day, Harry Scott
Anthrax is a severe bacterial infection caused by Bacillus anthracis, which produces a tripartite toxin that includes protective antigen (PA), lethal factor (LF) and edema factor (EF). A series of dominant-negative mutations have been previously iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04f68dc84fe32c965eede9ab1b53a64f
https://doi.org/10.1101/2020.06.15.152231
https://doi.org/10.1101/2020.06.15.152231
Autor:
Sireesha Mamillapalli, James G. Bann, Jarad Schiffer, Srinivas Gonti, Han Li, Fabiana Freire Mendes de Oliveira, Arturo Casadevall, Robert N. Brey
Publikováno v:
mSphere
mSphere, Vol 5, Iss 1 (2020)
mSphere, Vol 5, Iss 1, p e00556-19 (2020)
mSphere, Vol 5, Iss 1 (2020)
mSphere, Vol 5, Iss 1, p e00556-19 (2020)
The anthrax toxin PA is the major immunogen in the current anthrax vaccine (anthrax vaccine adsorbed). Improving the anthrax vaccine for avoidance of a cold chain necessitates improvements in the thermodynamic stability of PA. We address how stabiliz
Publikováno v:
Biochemistry. 60:1242-1242