Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Srinivas Chollangi"'
Publikováno v:
Neurobiology of Disease, Vol 34, Iss 3, Pp 535-544 (2009)
Preconditioning with moderate oxidative stress (e.g., moderate bright light or mild hypoxia) can induce changes in retinal tissue that protect photoreceptors from a subsequent dose of lethal oxidative stress. The mechanism underlying this induced pro
Externí odkaz:
https://doaj.org/article/9a3bd12b1cf648089b25a38641f20f84
Autor:
Simona Jusyte, Zheng Jian Li, Xuankuo Xu, Thomas Müller-Späth, Sanchayita Ghose, Srinivas Chollangi, James Angelo
Publikováno v:
Biotechnology and Bioengineering. 116:2275-2284
Multicolumn capture chromatography is gaining increased attention lately due to the significant economic and process advantages it offers compared with traditional batch mode chromatography. However, for wide adoption of this technology in clinical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11b9537293d9818270d18dc371a8beb
https://doi.org/10.1002/bit.27012
https://doi.org/10.1002/bit.27012
Autor:
Lauren Jenkins, Anthony J. Cura, Sanchayita Ghose, Kathryn L. Aron, Yunping Huang, Tyler Hageman, Srinivas Chollangi, Xuankuo Xu, Michael C. Borys, Susan Egan, Zheng Jian Li
Publikováno v:
Applied microbiology and biotechnology. 104(22)
The disulfide reduction of intact monoclonal antibodies (mAbs) and subsequent formation of low molecular weight (LMW) species pose a direct risk to product stability, potency, and patient safety. Although enzymatic mechanisms of reduction are well es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6078e5efebd9cd854220d071d92488ee
https://pubmed.ncbi.nlm.nih.gov/32997205
https://pubmed.ncbi.nlm.nih.gov/32997205
Autor:
Sanchayita Ghose, Xuankuo Xu, Zheng Jian Li, James Angelo, Massimo Morbidelli, Thomas Müller-Späth, Daniel Baur, Srinivas Chollangi
Publikováno v:
Biotechnology and Bioengineering. 116:87-98
In this study we introduce three process characterization approaches toward validation of continuous twin-column capture chromatography (CaptureSMB), referred to as "standard," "model assisted," and "hybrid." They are all based on a traditional risk-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a956aab337f784185c7ae0ef4e99c60a
https://doi.org/10.1002/bit.26849
https://doi.org/10.1002/bit.26849
Autor:
Daniel Baur, Zheng Jian Li, Thomas Müller-Späth, James Angelo, Massimo Morbidelli, Xuankuo Xu, Na Zhang, Sanchayita Ghose, Srinivas Chollangi
Publikováno v:
Journal of biotechnology. 285
Effect of particle size (85μm vs. 50μm) on the performance of continuous capture chromatography using Protein A affinity was evaluated in combination with varied feed titers, loading flow rates and target breakthrough using a Design of Experiments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f39745b58a047d7637446610e1ee021
https://pubmed.ncbi.nlm.nih.gov/30165118
https://pubmed.ncbi.nlm.nih.gov/30165118
Publikováno v:
Biotechnology and Bioengineering. 112:2292-2304
To be administered to patients, therapeutic monoclonal antibodies must have very high purity, with process related impurities like host-cell proteins (HCPs) and DNA reduced to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e8cf7c561daee417e5c79da5130deee
https://doi.org/10.1002/bit.25639
https://doi.org/10.1002/bit.25639
Autor:
Nripen Singh, Srinivas Chollangi
Publikováno v:
Process Scale Purification of Antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81b7b34acb0c842425f21b4ed817a681
https://doi.org/10.1002/9781119126942.ch4
https://doi.org/10.1002/9781119126942.ch4
Publikováno v:
Journal of Biological Chemistry. 287:32848-32859
Oncostatin M (OSM) and leukemia inhibitory factor are pleiotropic cytokines that belong to the interleukin-6 (IL-6) family. These cytokines play a crucial role in diverse biological events like inflammation, neuroprotection, hematopoiesis, metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7115acd06cd231f08b02d13a42120c2
https://doi.org/10.1074/jbc.m112.387324
https://doi.org/10.1074/jbc.m112.387324
Publikováno v:
Journal of Biological Chemistry. 287:23710-23717
Iron regulatory proteins play a principal role in maintaining cellular iron homeostasis by post-transcriptionally regulating factors responsible for iron uptake, utilization, and storage. An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12de47e70e7d7dc5e98db241905a168
https://doi.org/10.1074/jbc.m112.360404
https://doi.org/10.1074/jbc.m112.360404
Publikováno v:
Proceedings of the National Academy of Sciences. 106:21389-21394
Retinal degenerations are a class of neurodegenerative disorders that ultimately lead to blindness due to the death of retinal photoreceptors. In most cases, death is the result of long-term exposure to environmental, inflammatory, and genetic insult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d563e658a894158f9890e04718a840b
https://doi.org/10.1073/pnas.0906156106
https://doi.org/10.1073/pnas.0906156106