Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Srinidhi Varadharajan"'
Autor:
Stephanie M. Casillo, Taylor A. Gatesman, Akanksha Chilukuri, Srinidhi Varadharajan, Brenden J. Johnson, Daniel R. David Premkumar, Esther P. Jane, Tritan J. Plute, Robert F. Koncar, Ann-Catherine J. Stanton, Carlos A.O. Biagi-Junior, Callie S. Barber, Matthew E. Halbert, Brian J. Golbourn, Katharine Halligan, Andrea F. Cruz, Neveen M. Mansi, Allison Cheney, Steven J. Mullett, Clinton Van’t Land, Jennifer L. Perez, Max I. Myers, Nishant Agrawal, Joshua J. Michel, Yue-Fang Chang, Olena M. Vaske, Antony MichaelRaj, Frank S. Lieberman, James Felker, Sruti Shiva, Kelsey C. Bertrand, Nduka Amankulor, Costas G. Hadjipanayis, Kalil G. Abdullah, Pascal O. Zinn, Robert M. Friedlander, Taylor J. Abel, Javad Nazarian, Sriram Venneti, Mariella G. Filbin, Stacy L. Gelhaus, Stephen C. Mack, Ian F. Pollack, Sameer Agnihotri
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113557- (2024)
Summary: Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced by the hallmark histone mutation H3K27M, which results in aberrantly permissive activation of oncogenic signaling pathways. Previous stu
Externí odkaz:
https://doaj.org/article/a1cfb726d57743518bf0449e2947643f
Autor:
Tiina Sävilammi, Craig R. Primmer, Srinidhi Varadharajan, René Guyomard, Yann Guiguen, Simen R. Sandve, L. Asbjørn Vøllestad, Spiros Papakostas, Sigbjørn Lien
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 5, Pp 1283-1294 (2019)
Salmonids represent an intriguing taxonomical group for investigating genome evolution in vertebrates due to their relatively recent last common whole genome duplication event, which occurred between 80 and 100 million years ago. Here, we report on t
Externí odkaz:
https://doaj.org/article/2479b927af0746e2aba5be34f166a18d
Autor:
Stephen C. Mack, Benjamin Deneen, Kelsey C. Bertrand, Claudia L. Kleinman, Nada Jabado, Joanna Yi, Richard J. Gilbertson, Sameer Agnihotri, Kristian W. Pajtler, Donald W. Parsons, Susan M. Blaney, Murali M. Chintagumpala, Thomas F. Westbrook, Irtisha Singh, H. Courtney Hodges, Charles Y. Lin, Stefan M. Pfister, Daisuke Kawauchi, Felix Sahm, Luz A. De León, Peter R. Wang, Madeline Ngo, Sarah G. Injac, Baoli Hu, Robert Kupp, Kathleen Kong, Kristen L. Karlin, Calla Olson, Yuen San Chan, Ann-Catherine J. Stanton, Brian J. Golbourn, Dana Tlais, Alisha Kardian, Minerva Solis, Austin J. Stuckert, Bryan Rivas, Selin Jessa, Hsiao-Chi Chen, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade
93 gene signature that characterizes ZFTA-Rela mouse and human tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2455a45bb7a7160f6ff2e0c7dedb37da
https://doi.org/10.1158/2159-8290.22539655.v1
https://doi.org/10.1158/2159-8290.22539655.v1
Autor:
Richard J. Gilbertson, Javed Khan, Berkley E. Gryder, Katherine E. Masih, Stephen C. Mack, Benjamin Deneen, Kristian W. Pajtler, Daisuke Kawauchi, Stefan M. Pfister, Mohankumar Murugesan, Tuyu Zheng, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade, Marcus Widdess, Katherine Wickham-Rahrmann, Nadin Hoffmann, Chandra Sekhar Reddy Chilamakuri, Rory Stark, Stephane Ballereau, Erica Nathan, Sabrina Terranova, Lisa Ruff, Robert Kupp
ZFTA (C11orf95)—a gene of unknown function—partners with a variety of transcriptional coactivators in translocations that drive supratentorial ependymoma, a frequently lethal brain tumor. Understanding the function of ZFTA is key to developing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2cf8077f685aa539c0dc306a7178bc
https://doi.org/10.1158/2159-8290.c.6549395
https://doi.org/10.1158/2159-8290.c.6549395
Autor:
Stephen C. Mack, Benjamin Deneen, Kelsey C. Bertrand, Claudia L. Kleinman, Nada Jabado, Joanna Yi, Richard J. Gilbertson, Sameer Agnihotri, Kristian W. Pajtler, Donald W. Parsons, Susan M. Blaney, Murali M. Chintagumpala, Thomas F. Westbrook, Irtisha Singh, H. Courtney Hodges, Charles Y. Lin, Stefan M. Pfister, Daisuke Kawauchi, Felix Sahm, Luz A. De León, Peter R. Wang, Madeline Ngo, Sarah G. Injac, Baoli Hu, Robert Kupp, Kathleen Kong, Kristen L. Karlin, Calla Olson, Yuen San Chan, Ann-Catherine J. Stanton, Brian J. Golbourn, Dana Tlais, Alisha Kardian, Minerva Solis, Austin J. Stuckert, Bryan Rivas, Selin Jessa, Hsiao-Chi Chen, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade
Figure S2 supporting expression and localization of ZRfus in the mouse IUE model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5100705dc6a0f49c6241a385bfa4fe37
https://doi.org/10.1158/2159-8290.22539676
https://doi.org/10.1158/2159-8290.22539676
Autor:
Richard J. Gilbertson, Javed Khan, Berkley E. Gryder, Katherine E. Masih, Stephen C. Mack, Benjamin Deneen, Kristian W. Pajtler, Daisuke Kawauchi, Stefan M. Pfister, Mohankumar Murugesan, Tuyu Zheng, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade, Marcus Widdess, Katherine Wickham-Rahrmann, Nadin Hoffmann, Chandra Sekhar Reddy Chilamakuri, Rory Stark, Stephane Ballereau, Erica Nathan, Sabrina Terranova, Lisa Ruff, Robert Kupp
ZFTA-RELAFUS1 domain interactomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f467fd01dfbc5c80be3de2bf7c61a7e
https://doi.org/10.1158/2159-8290.22540496
https://doi.org/10.1158/2159-8290.22540496
Autor:
Richard J. Gilbertson, Javed Khan, Berkley E. Gryder, Katherine E. Masih, Stephen C. Mack, Benjamin Deneen, Kristian W. Pajtler, Daisuke Kawauchi, Stefan M. Pfister, Mohankumar Murugesan, Tuyu Zheng, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade, Marcus Widdess, Katherine Wickham-Rahrmann, Nadin Hoffmann, Chandra Sekhar Reddy Chilamakuri, Rory Stark, Stephane Ballereau, Erica Nathan, Sabrina Terranova, Lisa Ruff, Robert Kupp
ZFTAFUS-sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554cf95f82cf6ce8a36fb8fc663a6c95
https://doi.org/10.1158/2159-8290.22540487.v1
https://doi.org/10.1158/2159-8290.22540487.v1
Autor:
Stephen C. Mack, Benjamin Deneen, Kelsey C. Bertrand, Claudia L. Kleinman, Nada Jabado, Joanna Yi, Richard J. Gilbertson, Sameer Agnihotri, Kristian W. Pajtler, Donald W. Parsons, Susan M. Blaney, Murali M. Chintagumpala, Thomas F. Westbrook, Irtisha Singh, H. Courtney Hodges, Charles Y. Lin, Stefan M. Pfister, Daisuke Kawauchi, Felix Sahm, Luz A. De León, Peter R. Wang, Madeline Ngo, Sarah G. Injac, Baoli Hu, Robert Kupp, Kathleen Kong, Kristen L. Karlin, Calla Olson, Yuen San Chan, Ann-Catherine J. Stanton, Brian J. Golbourn, Dana Tlais, Alisha Kardian, Minerva Solis, Austin J. Stuckert, Bryan Rivas, Selin Jessa, Hsiao-Chi Chen, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade
More than 60% of supratentorial ependymomas harbor a ZFTA–RELA (ZRfus) gene fusion (formerly C11orf95–RELA). To study the biology of ZRfus, we developed an autochthonous mouse tumor model using in utero electroporation (IUE) of the embryonic mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e3a974b88b13a244bee5e4ff38026e0
https://doi.org/10.1158/2159-8290.c.6549148.v1
https://doi.org/10.1158/2159-8290.c.6549148.v1
Autor:
Debosmita Sardar, Hsiao-Chi Chen, Amanda Reyes, Srinidhi Varadharajan, Antrix Jain, Carrie Mohila, Rachel Curry, Brittney Lozzi, Kavitha Rajendran, Alexis Cervantes, Kwanha Yu, Ali Jalali, Ganesh Rao, Stephen C. Mack, Benjamin Deneen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(29)
Epigenetic dysregulation is a universal feature of cancer that results in altered patterns of gene expression that drive malignancy. Brain tumors exhibit subtype-specific epigenetic alterations; however, the molecular mechanisms responsible for these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b5804d5a6606e701a8b7fe45710634
https://pubmed.ncbi.nlm.nih.gov/35858326
https://pubmed.ncbi.nlm.nih.gov/35858326
Autor:
Selin Jessa, Abdulshakour Mohammadnia, Ashot S. Harutyunyan, Maud Hulswit, Srinidhi Varadharajan, Hussein Lakkis, Nisha Kabir, Zahedeh Bashardanesh, Steven Hébert, Damien Faury, Maria C. Vladoiu, Samantha Worme, Marie Coutelier, Brian Krug, Augusto Faria Andrade, Manav Pathania, Andrea Bajic, Alexander G. Weil, Benjamin Ellezam, Jeffrey Atkinson, Roy W. R. Dudley, Jean-Pierre Farmer, Sebastien Perreault, Benjamin A. Garcia, Valérie Larouche, Mathieu Blanchette, Livia Garzia, Aparna Bhaduri, Keith L. Ligon, Pratiti Bandopadhayay, Michael D. Taylor, Stephen C. Mack, Nada Jabado, Claudia L. Kleinman
Publikováno v:
Nat Genet
Canonical (H3.1/H3.2) and noncanonical (H3.3) histone 3 K27M-mutant gliomas have unique spatiotemporal distributions, partner alterations, and molecular profiles. The contribution of the cell-of-origin to these differences has been challenging to unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677717c5bfd30e952f67509fa7d12501
https://europepmc.org/articles/PMC9742294/
https://europepmc.org/articles/PMC9742294/