Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Srinath Sanda"'
Autor:
Kanika Kanchan, Gautam Shankar, Michelle F. Huffaker, Henry T. Bahnson, R Sharon Chinthrajah, Srinath Sanda, Monali Manohar, Hua Ling, Justin E. Paschall, George Du Toit, Ingo Ruczinski, Alkis Togias, Gideon Lack, Kari C. Nadeau, Stacie M. Jones, Gerald T. Nepom, Rasika A. Mathias
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
RationalePrevious studies identified an interaction between HLA and oral peanut exposure. HLA-DQA1*01:02 had a protective role with the induction of Ara h 2 epitope-specific IgG4 associated with peanut consumption during the LEAP clinical trial for p
Externí odkaz:
https://doaj.org/article/8558baf74a48493da4005046ba32951e
Autor:
Katharina Lambert, Kirsten E. Diggins, Britta E. Jones, Christian Hundhausen, Megan D. Maerz, Anne M. Hocking, Srinath Sanda, Carla J. Greenbaum, Peter S. Linsley, Karen Cerosaletti, Jane H. Buckner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Elevated levels and enhanced sensing of the pro-inflammatory cytokine interleukin-6 (IL-6) are key features of many autoimmune and inflammatory diseases. To better understand how IL-6 signaling may influence human T cell fate, we investigated the rel
Externí odkaz:
https://doaj.org/article/c773700586e44a7c8cb9899ec2c188f9
Autor:
Carla J. Greenbaum, Elisavet Serti, Katharina Lambert, Lia J. Weiner, Sai Kanaparthi, Sandra Lord, Stephen E. Gitelman, Darrell M. Wilson, Jason L. Gaglia, Kurt J. Griffin, William E. Russell, Philip Raskin, Antoinette Moran, Steven M. Willi, Eva Tsalikian, Linda A. DiMeglio, Kevan C. Herold, Wayne V. Moore, Robin Goland, Mark Harris, Maria E. Craig, Desmond A. Schatz, David A. Baidal, Henry Rodriguez, Kristina M. Utzschneider, Hendrik J. Nel, Carol L. Soppe, Karen D. Boyle, Karen Cerosaletti, Lynette Keyes-Elstein, S. Alice Long, Ranjeny Thomas, James G. McNamara, Jane H. Buckner, Srinath Sanda, for the ITN058AI EXTEND Study Team
Publikováno v:
JCI Insight, Vol 6, Iss 21 (2021)
Background IL-6 receptor (IL-6R) signaling drives development of T cell populations important to type 1 diabetes pathogenesis. We evaluated whether blockade of IL-6R with monoclonal antibody tocilizumab would slow loss of residual β cell function in
Externí odkaz:
https://doaj.org/article/083a57294536479793c92cf07ad43e13
Autor:
Michelle F. Huffaker, Srinath Sanda, Sindhu Chandran, Sharon A. Chung, E. William St. Clair, Gerald T. Nepom, Dawn E. Smilek
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved
Externí odkaz:
https://doaj.org/article/456ffed289e8483883fd5f8b1dd4ad4a
Autor:
Felipe de Jesus Cortez, David Gebhart, Peter V Robinson, David Seftel, Narges Pourmandi, Jordan Owyoung, Carolyn R Bertozzi, Darrell M Wilson, David M Maahs, Bruce A Buckingham, John R Mills, Matthew M Roforth, Sean J Pittock, Andrew McKeon, Kara Page, Wendy A Wolf, Srinath Sanda, Cate Speake, Carla J Greenbaum, Cheng-Ting Tsai
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242049 (2020)
Islet autoantibodies are predominantly measured by radioassay to facilitate risk assessment and diagnosis of type 1 diabetes. However, the reliance on radioactive components, large sample volumes and limited throughput renders radioassay testing cost
Externí odkaz:
https://doaj.org/article/3a43e86479fd4577be2fc7ea1a034780
Autor:
Ivana Durinovic-Belló, Vivian H Gersuk, Chester Ni, Rebecca Wu, Jerill Thorpe, Nicholas Jospe, Srinath Sanda, Carla J Greenbaum, Gerald T Nepom
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98074 (2014)
Fate determination for autoreactive T cells relies on a series of avidity-dependent interactions during T cell selection, represented by two general types of signals, one based on antigen expression and density during T cell development, and one base
Externí odkaz:
https://doaj.org/article/5c1f3d12ff434afd83a179e2502e4265
Autor:
Brian D Hondowicz, Katharine V Schwedhelm, Arnold Kas, Michael A Tasch, Crystal Rawlings, Nirasha Ramchurren, Martin McIntosh, Leonard A D'Amico, Srinath Sanda, Nathan E Standifer, Jay Shendure, Brad Stone
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29949 (2012)
The identification of novel T cell antigens is central to basic and translational research in autoimmunity, tumor immunology, transplant immunology, and vaccine design for infectious disease. However, current methods for T cell antigen discovery are
Externí odkaz:
https://doaj.org/article/f2025b1ba27e4c41b1153450df9f697c
Autor:
Jonathan Corren, David Larson, Matthew C. Altman, R. Max Segnitz, Pedro C. Avila, Paul A. Greenberger, Fuad Baroody, Mark H. Moss, Harold Nelson, Allison J. Burbank, Michelle L. Hernandez, David Peden, Sarbjit Saini, Stephen Tilles, Iftikhar Hussain, Don Whitehouse, Tielin Qin, Miguel Villarreal, Michelle Sever, Lisa M. Wheatley, Gerald T. Nepom, Srinath Sanda
Publikováno v:
Journal of Allergy and Clinical Immunology. 151:192-201
Thymic stromal lymphopoietin (TSLP) has been shown to play a central role in the initiation and persistence of allergic responses.We evaluated whether tezepelumab, a human monoclonal anti-TSLP antibody, improved the efficacy of subcutaneous allergen
Autor:
Justine Calise, Hannah DeBerg, Nahir Garabatos, Sugandhika Khosa, Veronique Bajzik, Lorena Botero Calderon, Kelly Aldridge, Mario Rosasco, Brian C. Ferslew, Tong Zhu, Ronald Smulders, Lisa M. Wheatley, Tanya M. Laidlaw, Tielin Qin, Gurunadh R. Chichili, Daniel C. Adelman, Mary Farrington, David Robinson, David Jeong, Stacie M. Jones, Srinath Sanda, David Larson, William W. Kwok, Carolyn Baloh, Gerald T. Nepom, Erik Wambre, Edwin H. Kim, Kari C. Nadeau, Anna Nowak-Wegrzyn, Robert A. Wood, Hugh A. Sampson, Amy M. Scurlock, Sharon Chinthrajah, Julie Wang, Robert D. Pesek, Sayantani B. Sindher, Mike Kulis, Jacqueline Johnson, Katharine Spain, Denise C. Babineau, Hyunsook Chin, Joy Laurienzo-Panza, null Rachel Yan, null Tielin Qin, Don Whitehouse, Michelle L. Sever, Marshall Plaut, A. Wesley Burks, Gina Marchesini, Kavitha Gilroy, Sylvia Posso, Sabrina Skiba, Thien-Son Nguyen, Adam Wojno, Tuan Nguyen, Vivian Gersuk, Quynh-Anh Nguyen, Jessica Garber, Kimberly O’Brien, Brandon Larson, C. Cousens-Jacobs, Alex Hu
Publikováno v:
Journal of Allergy and Clinical Immunology.
Autor:
Kathryn M. Sumpter, Sadana Balachandar, Janine Sanchez, Robert Rapaport, Anastasia Albanese-O'Neill, Catherina T. Pinnaro, Srinath Sanda, Alissa J. Roberts, Jenise C. Wong, Saketh Rompicherla, Shideh Majidi, Mary Pat Gallagher, Mariam Gangat, Osagie Ebekozien, Abha Choudhary, Tossaporn Seeherunvong, Brynn E. Marks, Ana L. Creo, Liana Gabriel, Meredith Wilkes, Guy T. Alonso, Jamie R. Wood, Anna Cymbaluk, Sarah K. Lyons, Neha S. Patel, Jose Jimenez-Vega
Publikováno v:
Journal of diabetes, vol 13, iss 8
Journal of Diabetes
Journal of Diabetes
Background Diabetes is a risk factor for poor COVID‐19 outcomes, but pediatric patients with type 1 diabetes are poorly represented in current studies. Methods T1D Exchange coordinated a US type 1 diabetes COVID‐19 registry. Forty‐six diabetes