Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Srimonta Gayen"'
Autor:
Milan Kumar Samanta, Srimonta Gayen, Clair Harris, Emily Maclary, Yumie Murata-Nakamura, Rebecca M. Malcore, Robert S. Porter, Patricia M. Garay, Christina N. Vallianatos, Paul B. Samollow, Shigeki Iwase, Sundeep Kalantry
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors show eutherian mammals co-opted the histone demethylase KDM5C during sex-chromosome evolution to induce X-chromosome inactivation by upregulating Xist expression selectively in females.
Externí odkaz:
https://doaj.org/article/c7bf99de72cb4d26b0b6c0c4c1912e66
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104465- (2022)
Summary: In mammals, transcriptional inactivation of one X chromosome in female compensates for the dosage of X-linked gene expression between the sexes. Additionally, it is believed that the upregulation of active X chromosome in male and female bal
Externí odkaz:
https://doaj.org/article/59b12b3a12db438c97268e2a6ab6d5ce
Autor:
Hemant Chandru Naik, Kishore Hari, Deepshikha Chandel, Susmita Mandal, Mohit Kumar Jolly, Srimonta Gayen
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102954- (2021)
Summary: Recently, allele-specific single-cell RNA-seq analysis has demonstrated widespread dynamic random monoallelic expression of autosomal genes (aRME) in different cell types. However, the prevalence of dynamic aRME during pregastrulation remain
Externí odkaz:
https://doaj.org/article/9bb4b297c9ec4b6e90e4c20a960e09f1
Autor:
Vinithra Iyer, Sheetal Tushir, Shreekant Verma, Sudeshna Majumdar, Srimonta Gayen, Rakesh Mishra, Utpal Tatu
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009810 (2021)
Hsp90 gene of G. lamblia has a split nature comprising two ORFs separated by 777 kb on chromosome 5. The ORFs of the split gene on chromosome 5 undergo transcription to generate independent pre-mRNAs that join by a unique trans-splicing reaction that
Externí odkaz:
https://doaj.org/article/cd162f0c3b4c43cc9073ff06028d3341
Autor:
Bharath Saravanan, Deepanshu Soota, Zubairul Islam, Sudeshna Majumdar, Rajat Mann, Sweety Meel, Umer Farooq, Kaivalya Walavalkar, Srimonta Gayen, Anurag Kumar Singh, Sridhar Hannenhalli, Dimple Notani
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008516 (2020)
Unliganded Estrogen receptor alpha (ERα) has been implicated in ligand-dependent gene regulation. Upon ligand exposure, ERα binds to several EREs relatively proximal to the pre-marked, unliganded ERα-bound sites and affects transient but robust ge
Externí odkaz:
https://doaj.org/article/5b925ab7e98540f4ba736bfe03e3d973
Autor:
Emily Maclary, Michael Hinten, Clair Harris, Shriya Sethuraman, Srimonta Gayen, Sundeep Kalantry
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-17 (2017)
Abstract Background Polycomb repressive complex 2 (PRC2) catalyzes histone H3K27me3, which marks many transcriptionally silent genes throughout the mammalian genome. Although H3K27me3 is associated with silenced gene expression broadly, it remains un
Externí odkaz:
https://doaj.org/article/dec5a82772184c3984dc5d5ad3e32a17
Autor:
Clair Harris, Marissa Cloutier, Megan Trotter, Michael Hinten, Srimonta Gayen, Zhenhai Du, Wei Xie, Sundeep Kalantry
Publikováno v:
eLife, Vol 8 (2019)
Imprinted X-inactivation silences genes exclusively on the paternally-inherited X-chromosome and is a paradigm of transgenerational epigenetic inheritance in mammals. Here, we test the role of maternal vs. zygotic Polycomb repressive complex 2 (PRC2)
Externí odkaz:
https://doaj.org/article/a4a0723155f54352b221fad9a00cbea3
Autor:
Kenichiro Taniguchi, Yue Shao, Ryan F. Townshend, Yu-Hwai Tsai, Cynthia J. DeLong, Shawn A. Lopez, Srimonta Gayen, Andrew M. Freddo, Deming J. Chue, Dennis J. Thomas, Jason R. Spence, Benjamin Margolis, Sundeep Kalantry, Jianping Fu, K. Sue O’Shea, Deborah L. Gumucio
Publikováno v:
Stem Cell Reports, Vol 5, Iss 6, Pp 954-962 (2015)
We demonstrate that dissociated human pluripotent stem cells (PSCs) are intrinsically programmed to form lumens. PSCs form two-cell cysts with a shared apical domain within 20 hr of plating; these cysts collapse to form monolayers after 5 days. Expre
Externí odkaz:
https://doaj.org/article/708b3ade14564d4385e90ce1c6d3c873
Publikováno v:
Cell Reports, Vol 11, Iss 8, Pp 1251-1265 (2015)
Differentiating pluripotent epiblast cells in eutherians undergo random X-inactivation, which equalizes X-linked gene expression between the sexes by silencing one of the two X-chromosomes in females. Tsix RNA is believed to orchestrate the initiatio
Externí odkaz:
https://doaj.org/article/d6f0dc97ff2345f4a07a7786cbc17a8c
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187172 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0150763.].
Externí odkaz:
https://doaj.org/article/dd1f3655c128465a92789909c9666ca4