Sex‐Specific Differences in Gsα‐Mediated Signaling Downstream of PTH1R Activation by Abaloparatide in Bone

Autor: Srilatha Swami, Joshua Johnson, Lawrence A Vecchi, Matthew J Kim, Beate Lanske, Rachelle W Johnson, Joy Y Wu

Publikováno v: JBMR Plus, Vol 6, Iss 12, Pp n/a-n/a (2022)

ABSTRACT Teriparatide, recombinant parathyroid hormone (PTH[1‐34]), and abaloparatide, an analogue of PTH related‐peptide (PTHrP[1‐34]), are both anabolic medications for osteoporosis that target the PTH receptor PTH1R. PTH1R is a G protein–c

Externí odkaz: https://doaj.org/article/962b5a7ca153486f892fb3b1483c1987

Histopathology of osteogenesis imperfecta bone. Supramolecular assessment of cells and matrices in the context of woven and lamellar bone formation using light, polarization and ultrastructural microscopy

Autor: Kathleen Maguire, Frederic Shapiro, Hui Zhu, Srilatha Swami, Joy Y. Wu, Jamie Wang, Evelyn Flynn

Publikováno v: Bone Reports
Bone Reports, Vol 14, Iss, Pp 100734-(2021)

Diaphyseal long bone cortical tissue from 30 patients with lethal perinatal Sillence II and progressively deforming Sillence III osteogenesis imperfecta (OI) has been studied at multiple levels of structural resolution. Interpretation in the context

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdb967793f1fbf6be51d2d60c976d1b
http://europepmc.org/articles/PMC7898004

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

Autor: Kristy Red-Horse, William R. Goodyer, Lei Tian, James B Hu, Michael Hesse, Haodi Wu, Paul J. M. Wijnker, Jan W. Buikema, Sean M. Wu, Daniel Lee, Yi Miao, K. Christopher Garcia, Joost P.G. Sluijter, Joy Y. Wu, David T. Paik, Aimee Beck, Larissa M. Dorsch, Srilatha Swami, Jolanda van der Velden, Pieter A. Doevendans, Benjamin Beyersdorf, Caroline Geisen, Guang Li, Sharon L. Paige, Alain van Mil, Renee G.C. Maas, Soah Lee, Nazan Puluca, Siyeon Rhee, Orlando Chirikian, Joseph C. Wu, Francisco X Galdos, Bernd K. Fleischmann, Stefan Jovinge, Maike Schuldt, Sneha Venkamatran, Vahid Serpooshan

Publikováno v: Cell Stem Cell
Buikema, J W, Lee, S, Goodyer, W R, Maas, R G, Chirikian, O, Li, G, Miao, Y, Paige, S L, Lee, D, Wu, H, Paik, D T, Rhee, S, Tian, L, Galdos, F X, Puluca, N, Beyersdorf, B, Hu, J, Beck, A, Venkamatran, S, Swami, S, Wijnker, P, Schuldt, M, Dorsch, L M, van Mil, A, Red-Horse, K, Wu, J Y, Geisen, C, Hesse, M, Serpooshan, V, Jovinge, S, Fleischmann, B K, Doevendans, P A, van der Velden, J, Garcia, K C, Wu, J C, Sluijter, J P G & Wu, S M 2020, ' Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes ', Cell Stem Cell, vol. 27, no. 1, pp. 50-63 . https://doi.org/10.1016/j.stem.2020.06.001
Cell Stem Cell, 27(1), 50-63. Cell Press

Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in vitro can expand CMs modestly (5-fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b34017e3e4efaa6fb5e71268924483c
https://doi.org/10.1016/j.stem.2020.06.001

Pluripotent stem cells as a source of osteoblasts for bone tissue regeneration

Autor: Joy Y. Wu, Hui Zhu, Srilatha Swami, Takaharu Kimura

Publikováno v: Biomaterials. 196

Appropriate and abundant sources of bone-forming osteoblasts are essential for bone tissue engineering. Pluripotent stem cells can self-renew and thereby offer a potentially unlimited supply of osteoblasts, a significant advantage over other cell sou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1e5710c2812fa79111b66e4727d859
https://pubmed.ncbi.nlm.nih.gov/29456164

Transrepression of the estrogen receptor promoter by calcitriol in human breast cancer cells via two negative vitamin D response elements

Autor: David Feldman, Aruna V. Krishnan, Johan Lundqvist, Srilatha Swami, Lihong Peng

Publikováno v: Endocrine-Related Cancer. 20:565-577

Calcitriol (1,25-dihydroxyvitamin D3), the hormonally active metabolite of vitamin D, exerts its anti-proliferative activity in breast cancer (BCa) cells by multiple mechanisms including the downregulation of the expression of estrogen receptor α (E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7356c5b932e5456f25a2e5d6c457f1
https://doi.org/10.1530/erc-12-0281