Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Srilalitha Kuruganti"'
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81331 (2013)
Though operationally defined as cis-regulatory elements, enhancers can also communicate with promoters on a separate homolog in trans, a mechanism that has been suggested to account for the ability of certain alleles of the same gene to complement on
Externí odkaz:
https://doaj.org/article/67186252f0ad4082ac3b956e90125a04
Autor:
Mark R. Walter, Paul A. Goepfert, Ashlesha Deshpande, W. Winn Chatham, Bethany D. Harris, Srilalitha Kuruganti
Publikováno v:
Lupus
Background/objectiveType-I interferons contribute to pathogenesis in systemic lupus erythematosus, including nephritis. Interferons consist of a family of 16 proteins yet are often characterized in patients without knowledge of the specific interfero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed25743875a15faba5f3b8663c9c4bd
https://europepmc.org/articles/PMC7427124/
https://europepmc.org/articles/PMC7427124/
Autor:
Harris, Bethany D, Srilalitha Kuruganti, Ashlesha Deshpande, Goepfert, Paul A, W Winn Chatham, Walter, Mark R
Supplemental material, sj-pdf-1-lup-10.1177_0961203320935976 for Characterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urine by Bethany D Harris, Srilalitha Kuruganti, Ashlesha Deshpande, Paul A Goepfert, W Winn Chatham
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08b17460f2430010be90a410a319e0a6
Autor:
Bethany D. Harris, R. Mark L. Buller, Jeffrey A. Speir, Jill Schriewer, Shane Miersch, Sachdev S. Sidhu, Mark R. Walter, Ashlesha Deshpande, Srilalitha Kuruganti
Publikováno v:
Journal of Biological Chemistry. 291:447-461
Exogenous cytokine therapy can induce systemic toxicity, which might be prevented by activating endogenously produced cytokines in local cell niches. Here we developed antibody-based activators of cytokine signaling (AcCS), which recognize cytokines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eafec645956533e80e0f40782576ad9
https://doi.org/10.1074/jbc.m115.665943
https://doi.org/10.1074/jbc.m115.665943
Publikováno v:
Protein engineering, designselection : PEDS. 30(9)
The 12 distinct subtypes that comprise the interferon alpha (IFNα) family of cytokines possess anti-viral, anti-proliferative and immunomodulatory activities. They are implicated in the etiology and progression of many diseases, and also used as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108f5dc36a6b3587c11c3435dba97805
https://pubmed.ncbi.nlm.nih.gov/28981904
https://pubmed.ncbi.nlm.nih.gov/28981904
Publikováno v:
Protein Expression and Purification. 103:75-83
Thirteen human interferon-α (IFNα) subtypes were expressed in Escherichiacoli and purified using an N-terminal affinity tag from the prodomain of subtilisin. IFNα subtypes were expressed in soluble form and purified from cell lysates or refolded a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef21ab36f8f6239bc11645ef25d1ca78
https://doi.org/10.1016/j.pep.2014.08.010
https://doi.org/10.1016/j.pep.2014.08.010
Publikováno v:
Protein Science. 22:1100-1108
A method for analyzing ligand–receptor binding kinetics is described, which is based on an engineered FC domain (FChk) that forms a covalent heterodimer. To validate the system, the type I IFN receptors (IFNAR1 and IFNAR2) were expressed as IFNAR1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9dcb746ec963b670b922123208eb7f
https://doi.org/10.1002/pro.2285
https://doi.org/10.1002/pro.2285
Autor:
Mariano Labrador, Shih-Jui Hsu, Shaofei Zhang, Maria P. Plata, Hyuckjoon Kang, Srilalitha Kuruganti
Publikováno v:
Chromosoma. 118:303-322
Ribosomal DNA genes (rDNA) are found in tandem arrays of hundreds of repeated genes, but only a fraction of these genes are actively transcribed. The regulatory mechanism controlling the transition between active and inactive rDNA in higher eukaryote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bea067293289a2348d954a024def24
https://doi.org/10.1007/s00412-008-0198-9
https://doi.org/10.1007/s00412-008-0198-9
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 11, p e81331 (2013)
PLoS ONE, Vol 8, Iss 11, p e81331 (2013)
Though operationally defined as cis-regulatory elements, enhancers can also communicate with promoters on a separate homolog in trans, a mechanism that has been suggested to account for the ability of certain alleles of the same gene to complement on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754bec776b1247d2cc873789266d2b5b
https://pubmed.ncbi.nlm.nih.gov/24236213
https://pubmed.ncbi.nlm.nih.gov/24236213
Autor:
Mark R. Walter, Naomi J. Logsdon, Srilalitha Kuruganti, Brandi C. Jones, Sung-il Yoon, Bethany D. Harris
Publikováno v:
The Journal of biological chemistry. 287(32)
Human interleukin-10 (hIL-10) is a pleiotropic cytokine that is able to suppress or activate cellular immune responses to protect the host from invading pathogens. Epstein-Barr virus (EBV) encodes a viral IL-10 (ebvIL-10) in its genome that has retai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03d98fde824d24f3828a40fd64dbf70
https://pubmed.ncbi.nlm.nih.gov/22692218
https://pubmed.ncbi.nlm.nih.gov/22692218