Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Srilakshmi, Yalavarthi"'
Autor:
Matthew C. Woodruff, Kevin S. Bonham, Fabliha A. Anam, Tiffany A. Walker, Caterina E. Faliti, Yusho Ishii, Candice Y. Kaminski, Martin C. Ruunstrom, Kelly Rose Cooper, Alexander D. Truong, Adviteeya N. Dixit, Jenny E. Han, Richard P. Ramonell, Natalie S. Haddad, Mark E. Rudolph, Srilakshmi Yalavarthi, Viktoria Betin, Ted Natoli, Sherwin Navaz, Scott A. Jenks, Yu Zuo, Jason S. Knight, Arezou Khosroshahi, F. Eun-Hyung Lee, Ignacio Sanz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract While immunologic correlates of COVID-19 have been widely reported, their associations with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of PASC presentations, understanding if specific disease features ass
Externí odkaz:
https://doaj.org/article/9d2aa0b3afa9462d9b276355450d5845
Autor:
Allison C. Billi, Rachael Wasikowski, Feiyang Ma, Srilakshmi Yalavarthi, Claire K. Hoy, Yu Zuo, Matthew T. Patrick, Neha Shah, Christine Parker, Chad Aaronson, Alyssa Harbaugh, Matthew F. Lucido, Kerby Shedden, Krishna Rao, Heidi B. IglayReger, Charles F. Burant, J. Michelle Kahlenberg, Lam C. Tsoi, Johann E. Gudjonsson, Jason S. Knight, Yogendra Kanthi
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Risk of severe disease and death due to COVID-19 is increased in certain patient demographic groups, including those of advanced age, male sex, and obese body mass index. Investigations of the biological variations that contribute to this risk have b
Externí odkaz:
https://doaj.org/article/db7b5f12e7994ea49aa1f66cc4afaa01
Autor:
Yu Zuo, Mark Warnock, Alyssa Harbaugh, Srilakshmi Yalavarthi, Kelsey Gockman, Melanie Zuo, Jacqueline A. Madison, Jason S. Knight, Yogendra Kanthi, Daniel A. Lawrence
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients. Understanding the balance between coagulation and fibri
Externí odkaz:
https://doaj.org/article/15613acf473e49538de79328cd7add3a
Autor:
Midori L. Wasielewski, Katherine Nguyen, Srilakshmi Yalavarthi, Pallavi Ekbote, Priyan D. Weerappuli, Jason S. Knight, Shuichi Takayama
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3222 (2023)
This study analyzed the nuclease- and serum-driven degradation of millimeter-scale, circular DNA–histone mesostructures (DHMs). DHMs are bioengineered chromatin meshes of defined DNA and histone compositions designed as minimal mimetics of physiolo
Externí odkaz:
https://doaj.org/article/535d08251b7d48c19eeb332110a76bb7
Autor:
Hui Shi, Alex A. Gandhi, Stephanie A. Smith, Qiuyu Wang, Diane Chiang, Srilakshmi Yalavarthi, Ramadan A. Ali, Chao Liu, Gautam Sule, Pei-Suen Tsou, Yu Zuo, Yogendra Kanthi, Evan A. Farkash, Jiandie D. Lin, James H. Morrissey, Jason S. Knight
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Neutrophil-mediated activation and injury of the endothelium play roles in the pathogenesis of diverse disease states ranging from autoimmunity to cancer to COVID-19. Neutralization of cationic proteins (such as neutrophil extracellular trap–derive
Externí odkaz:
https://doaj.org/article/841d7563afdf4a2684c13199b322ad80
Autor:
Yu Zuo, Srilakshmi Yalavarthi, Sherwin A. Navaz, Claire K. Hoy, Alyssa Harbaugh, Kelsey Gockman, Melanie Zuo, Jacqueline A. Madison, Hui Shi, Yogendra Kanthi, Jason S. Knight
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
The release of neutrophil extracellular traps (NETs) by hyperactive neutrophils is recognized to play an important role in the thromboinflammatory milieu inherent to severe presentations of COVID-19. At the same time, a variety of functional autoanti
Externí odkaz:
https://doaj.org/article/bd9892159dff405fa75c32127a32a3a9
Autor:
Ramadan A. Ali, Alex A. Gandhi, He Meng, Srilakshmi Yalavarthi, Andrew P. Vreede, Shanea K. Estes, Olivia R. Palmer, Paula L. Bockenstedt, David J. Pinsky, Joan M. Greve, Jose A. Diaz, Yogendra Kanthi, Jason S. Knight
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Antiphospholipid syndrome is characterised by increased neutrophil extracellular trap formation (NETosis) and, consequently, increased thrombotic events. Here Ali et al. show that treatment with adenosine receptor agonists suppresses NETosis and veno
Externí odkaz:
https://doaj.org/article/d8ca98b7f1d54784a2dbed7642ccb42a
Autor:
Ramadan A. Ali, Alex A. Gandhi, Lipeng Dai, Julia Weiner, Shanea K. Estes, Srilakshmi Yalavarthi, Kelsey Gockman, Duxin Sun, Jason S. Knight
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Ginger is known to have antiinflammatory and antioxidative effects and has traditionally been used as an herbal supplement in the treatment of various chronic diseases. Here, we report antineutrophil properties of 6-gingerol, the most abundant bioact
Externí odkaz:
https://doaj.org/article/e0feddd6aa7d428fab958f336fc5bf0f
Autor:
Nitin Kumar, Yu Zuo, Srilakshmi Yalavarthi, Kristina L. Hunker, Jason S. Knight, Yogendra Kanthi, Andrea T. Obi, Santhi K. Ganesh
Publikováno v:
Viruses, Vol 13, Iss 11, p 2209 (2021)
Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The vascular effects of androgen signaling and inflammatory cytokines in severe acute respiratory synd
Externí odkaz:
https://doaj.org/article/29ea2c7fc975437b97d2aac79e1dc36f
Autor:
Nirit Mor-Vaknin, Anjan Saha, Maureen Legendre, Carmelo Carmona-Rivera, M Asif Amin, Bradley J. Rabquer, Marta J. Gonzales-Hernandez, Julie Jorns, Smriti Mohan, Srilakshmi Yalavarthi, Dave A. Pai, Kristine Angevine, Shelley J. Almburg, Jason S. Knight, Barbara S. Adams, Alisa E. Koch, David A. Fox, David R. Engelke, Mariana J. Kaplan, David M. Markovitz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK-t
Externí odkaz:
https://doaj.org/article/2c912d0db4e646ad89d036163808223e