Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Srikrishnan Mallipeddi"'
Autor:
Xiaoyu Ma, Srikrishnan Mallipeddi, Michael S. Malamas, Han Zhou, Alexandros Makriyannis, Chandrashekhar Honrao, Othman Benchama, JodiAnne T. Wood, Jimit Girish Raghav
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:4963-4970
New oximes short-acting CB1 agonists were explored by the introduction of an internal oxime and polar groups at the C3 alkyl tail of Δ8-THC. The scope of the research was to drastically alter two important physicochemical properties hydrophobicity (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1b6844b78d2c1075e54bc8f7133537
https://doi.org/10.1016/j.bmc.2018.08.003
https://doi.org/10.1016/j.bmc.2018.08.003
Autor:
Jimit Girish Raghav, Othman Benchama, Alexandros Makriyannis, Srikrishnan Mallipeddi, Michael Z. Leonard, Rishi Sharma, Chandrashekhar Honrao, Bin Zhang, Shashank Kulkarni, Shan Jiang, Carol A. Paronis, Jack Bergman, Spyros P. Nikas, Torbjörn U. C. Järbe
Publikováno v:
Journal of Medicinal Chemistry. 59:6903-6919
In pursuit of safer controlled-deactivation cannabinoids with high potency and short duration of action, we report the design, synthesis, and pharmacological evaluation of novel C9- and C11-hydroxy-substituted hexahydrocannabinol (HHC) and tetrahydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3e3d2eb9ab2c1c2ea5f178a949a4d5
https://doi.org/10.1021/acs.jmedchem.6b00717
https://doi.org/10.1021/acs.jmedchem.6b00717
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
The human cannabinoid 1 receptor (hCB1) is involved in numerous physiological processes and therefore provides a wide scope of potential therapeutic opportunities to treat maladies such as obesity, cardio-metabolic disorders, substance abuse, neuropa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361f7b7921dc9d2a7dfc23b612d94957
http://europepmc.org/articles/PMC5811539
http://europepmc.org/articles/PMC5811539
Publikováno v:
Biochemical pharmacology. 128
The phenomenon of functional selectivity, whereby a ligand preferentially directs the information output of a G-protein coupled receptor (GPCR) along (a) particular effector pathway(s) and away from others, has redefined traditional GPCR signaling pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31313c43dab130ef8a47607a8eabe6aa
https://pubmed.ncbi.nlm.nih.gov/27890725
https://pubmed.ncbi.nlm.nih.gov/27890725
Autor:
John R. Engen, Nikolai Zvonok, Alexandros Makriyannis, Brent A. Kochert, Srikrishnan Mallipeddi
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::040fbf0492a9346541d2c4276e0cc405
https://doi.org/10.1096/fasebj.29.1_supplement.770.11
https://doi.org/10.1096/fasebj.29.1_supplement.770.11
Autor:
Han Zhou, Srikrishnan Mallipeddi, Spyros P. Nikas, Aneetha Halikhedkar, Go Ogawa, Marcus A. Tius, Alexandros Makriyannis
Publikováno v:
Journal of medicinal chemistry. 58(7)
The aliphatic side chain plays a pivotal role in determining the cannabinergic potency of tricyclic classical cannabinoids, and we have previously shown that this chain could be substituted successfully by adamantyl or other polycyclic groups. In an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bd4ac666f531470ad12fe4bbb7e931
https://pubmed.ncbi.nlm.nih.gov/25760146
https://pubmed.ncbi.nlm.nih.gov/25760146
Autor:
Spyros P. Nikas, Rishi Sharma, Alexandros Makriyannis, Jason J. Guo, Srikrishnan Mallipeddi, JodiAnne T. Wood
Publikováno v:
ACS medicinal chemistry letters. 5(4)
As a part of our controlled-deactivation ligand development project, we recently disclosed a series of (-)-Δ(8)-tetrahydrocannabinols (THCs) with a metabolically labile ester group at the 2'-position of the side chain. Now, we have replaced the C-ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83295ff8cf17539bc622139241f7fbbc
https://pubmed.ncbi.nlm.nih.gov/24900848
https://pubmed.ncbi.nlm.nih.gov/24900848
Autor:
Go Ogawa, Marcus A. Tius, Han Zhou, SpyrosP. Nikas, Aneetha Halikhedkar, Srikrishnan Mallipeddi, Alexandros Makriyannis
Publikováno v:
Journal of Medicinal Chemistry; Apr2015, Vol. 58 Issue 7, p3104-3116, 13p