Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Srikanth Kotapati"'
Autor:
Julie A. Zorn, Matthew L. Wheeler, Ralston M. Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y.-C. Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M. West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract T-cell engagers (TCEs) are a growing class of biotherapeutics being investigated in the clinic for treatment of a variety of hematological and solid tumor indications. However, preclinical evaluation of TCEs in vivo has been mostly limited t
Externí odkaz:
https://doaj.org/article/3a2265c1ac814c838bd81c163786a89d
Autor:
Natalia Tretyakova, Loïc Le Marchand, Daniel O. Stram, Maarit Tiirikainen, Sungshim L. Park, Amanda Esades, Srikanth Kotapati, Yesha M. Patel, Emily J. Boldry
Background: 1,3-Butadiene (BD) is an important carcinogen in tobacco smoke that undergoes metabolic activation to DNA-reactive epoxides. These species can be detoxified via glutathione conjugation and excreted in urine as the corresponding N-acetylcy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a07abec4c556008d55c31acf4dd124
https://doi.org/10.1158/1055-9965.c.6515661.v1
https://doi.org/10.1158/1055-9965.c.6515661.v1
Autor:
Loïc Le Marchand, Natalia Tretyakova, Sharon E. Murphy, Maarit Tiirikainen, Lynne R. Wilkens, Srikanth Kotapati, Sungshim Lani Park
Supplemental Table 1. Spearman's partial correlations (r)a between 1,3 butadiene urinary metabolites and nicotine equivalents.Supplemental Table 2. Geometric means (95% Confidence Limits) for the 1,3 butadiene metabolite, MHBMA (ng/mg Cr),stratified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4daffe2a50a8dcc98d6ba308291d0cf4
https://doi.org/10.1158/1055-9965.22435761
https://doi.org/10.1158/1055-9965.22435761
Autor:
Loïc Le Marchand, Natalia Tretyakova, Sharon E. Murphy, Maarit Tiirikainen, Lynne R. Wilkens, Srikanth Kotapati, Sungshim Lani Park
Background: We hypothesize that the differences in lung cancer risk in Native Hawaiians, whites, and Japanese Americans may, in part, be due to variation in the metabolism of 1,3-butadiene, one of the most abundant carcinogens in cigarette smoke.Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d767cb874f3db4ce45a3bcaa762fca
https://doi.org/10.1158/1055-9965.c.6515088
https://doi.org/10.1158/1055-9965.c.6515088
Autor:
Natalia Tretyakova, Loïc Le Marchand, Daniel O. Stram, Maarit Tiirikainen, Sungshim L. Park, Amanda Esades, Srikanth Kotapati, Yesha M. Patel, Emily J. Boldry
Experimental details Supplement S-1. Details of HPLC-ESI-MS/MS methodology. Tables Supplementary Table 1. Geometric means (95% confidence limits) for urinary MHBMA and DHBMA by race/ethnicity and sex. Values are given in ng/mg creatinine (Cr). Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f765ae70e6c29147c2e489eeba1464
https://doi.org/10.1158/1055-9965.22436994.v1
https://doi.org/10.1158/1055-9965.22436994.v1
Autor:
Sayumi Yamazoe, Srikanth Kotapati, Jason M. Hogan, Sean M. West, Xiaodi A. Deng, SJ Diong, Jaren Arbanas, Thien Anh Nguyen, Aarti Jashnani, Diksha Gupta, Arvind Rajpal, Gavin Dollinger, Pavel Strop
Publikováno v:
Bioconjugate Chemistry. 33:576-585
Autor:
Michael A. Schmidt, Chunshan Xie, Naidu S. Chowdari, Ankita G. Niyogi, David R. Langley, Heng Cheng, Gregory D. Vite, Sivakrishna Guturi, Rajappa Vaidyanathan, Sanjeev Gangwar, Ivar M. McDonald, Kishorekumar Kanagavel, Yichen Tan, Prasanna Sivaprakasam, Souvik Rakshit, Chin Pan, Umamaheswararao Kanusu, Martin D. Eastgate, Madhura Deshpande, Somprabha Sidhar, Bin Zheng, Christiana I. Iwuagwu, Michael R. Luzung, Ganapathy Sarma, Kevin M. Peese, Thirumalai Lakshminarasimhan, Patrick G. Holder, Pina M. Cardarelli, Patricia Cho, Srikanth Kotapati, Chetana Rao
Publikováno v:
ACS Med Chem Lett
[Image: see text] A new series with the tetrahydroisoquinoline-fused benzodiazepine (TBD) ring system combined with the surrogates of (1-methyl-1H-pyrrol-3-yl)benzene (“MPB”) payloads were designed and executed for conjugation with a monoclonal a
Autor:
Arvind Rajpal, Mary Huber, Patrick G. Holder, Xiaodi A Deng, Jason M. Hogan, Sanjeev Gangwar, Gavin Dollinger, Xiang Shao, Sayumi Yamazoe, Vandana Lamba, Chetana Rao, Srikanth Kotapati, Pavel Strop, Sean M. West, Cong Qiang
Publikováno v:
Bioconjugate Chemistry. 31:1199-1208
Antibody-drug conjugates (ADCs) are a therapeutic modality that traditionally enable the targeted delivery of highly potent cytotoxic agents to specific cells such as tumor cells. More recently, antibodies have been used to deliver molecules such as
Autor:
Rajesh Kishore Kumar Sanku, Qiang Cong, Shrikant Deshpande, Vangipuram S. Rangan, Sanjeev Gangwar, Naidu S. Chowdari, Yam B. Poudel, Chetana Rao, Pina M. Cardarelli, David Passmore, Pavel Strop, Sayumi Yamazoe, Srikanth Kotapati, Gavin Dollinger, Arvind Rajpal
Publikováno v:
Analytical Chemistry. 92:2065-2073
Antibody drug conjugates (ADCs) can undergo in vivo biotransformation (e.g., payload metabolism, deconjugation) leading to reduced or complete loss of activity. The location/site of conjugation of payload-linker can have an effect on ADC stability an
Autor:
Julie A. Zorn, Matthew L. Wheeler, Ralston M. Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y.-C. Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M. West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop
Publikováno v:
Scientific reports. 12(1)
T-cell engagers (TCEs) are a growing class of biotherapeutics being investigated in the clinic for treatment of a variety of hematological and solid tumor indications. However, preclinical evaluation of TCEs in vivo has been mostly limited to xenogra