Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Srikanth, Mairpady Shambat"'
Autor:
Alejandro Gómez-Mejia, Mariano Orlietti, Andrea Tarnutzer, Srikanth Mairpady Shambat, Annelies S. Zinkernagel
Publikováno v:
mSphere, Vol 9, Iss 10 (2024)
ABSTRACT The human pathobiont Streptococcus pyogenes forms biofilms and causes infections, such as pharyngotonsillitis and necrotizing fasciitis. Bacterial biofilms are more resilient to antibiotic treatment, and new therapeutic strategies are needed
Externí odkaz:
https://doaj.org/article/090ca32e6e4142708f637e2585f22d53
Autor:
Nadia Keller, Mathilde Boumasmoud, Federica Andreoni, Andrea Tarnutzer, Manuela von Matt, Thomas C. Scheier, Jana Epprecht, David Weller, Alejandro Gómez-Mejia, Markus Huemer, Donata von Reibnitz, Duveken B. Y. Fontein, Ewerton Marques-Maggio, Reto A. Schuepbach, Srikanth Mairpady-Shambat, Silvio D. Brugger, Annelies S. Zinkernagel
Publikováno v:
mSphere, Vol 9, Iss 9 (2024)
ABSTRACT Group A Streptococcus (GAS) necrotizing fasciitis (NF) is a difficult-to-treat bacterial infection associated with high morbidity and mortality despite extensive surgery and targeted antibiotic treatment. Difficult-to-treat infections are of
Externí odkaz:
https://doaj.org/article/a3445359d53a4465884d6865a96d6df4
Autor:
Laura Marquardt, Federica Andreoni, Mathilde Boumasmoud, Tiziano A. Schweizer, Dorothea M. Heuberger, Elena Parietti, Sanne Hertegonne, Jana Epprecht, Dario Mattle, Anna K. Raez, Ewerton Marques‐Maggio, Reto A. Schuepbach, Barbara Hasse, Srikanth Mairpady‐Shambat, Silvio D. Brugger, Annelies S. Zinkernagel
Publikováno v:
MicrobiologyOpen, Vol 13, Iss 1, Pp n/a-n/a (2024)
Abstract Group A streptococcal (GAS; aka Streptococcus pyogenes) meningitis is a fulminant disease associated with high morbidity and mortality. To elucidate the mechanisms underlying the invasiveness of GAS in meningitis, we compared GAS isolates de
Externí odkaz:
https://doaj.org/article/f22407c14bca41b089746197c77dec28
Autor:
Anja P. Keller, Markus Huemer, Chun-Chi Chang, Srikanth Mairpady Shambat, Caroline Bjurnemark, Nicole Oberortner, Michaela V. Santschi, Léa V. Zinsli, Christian Röhrig, Anna M. Sobieraj, Yang Shen, Fritz Eichenseher, Annelies S. Zinkernagel, Martin J. Loessner, Mathias Schmelcher
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT The current standard of treatment for chronic staphylococcal osteomyelitis entails high doses of antibiotics over the course of several weeks. Biofilm-associated and intracellular persisters are key factors contributing to therapeutic failur
Externí odkaz:
https://doaj.org/article/6260294adfd2410d95328a1b7ada479c
Autor:
Anna K. Räz, Federica Andreoni, Mathilde Boumasmoud, Judith Bergada-Pijuan, Tiziano A. Schweizer, Srikanth Mairpady Shambat, Barbara Hasse, Annelies S. Zinkernagel, Silvio D. Brugger
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Staphylococcus aureus carriage is a risk factor for invasive infections. Unique genetic elements favoring the transition from colonizing to invasive phenotype have not yet been identified, and phenotypic adaptation traits are understudied. W
Externí odkaz:
https://doaj.org/article/75d2ceecac8d4109af782784959115fc
Autor:
Tiziano A. Schweizer, Srikanth Mairpady Shambat, Vanina Dengler Haunreiter, Carlos A. Mestres, Alberto Weber, Francesco Maisano, Annelies S. Zinkernagel, Barbara Hasse
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 10, Pp 2448-2452 (2020)
Prosthetic vascular graft infections of the thoracic aorta are rare but can be fatal. Our comparison of collagen- and gelatin-coated grafts showed that collagen-coated grafts were associated with increased biofilm formation and bacterial adherence in
Externí odkaz:
https://doaj.org/article/7d588ec3946e4530a34bbb573b056ee5
Autor:
Srikanth Mairpady Shambat, Alejandro Gómez-Mejia, Tiziano A Schweizer, Markus Huemer, Chun-Chi Chang, Claudio Acevedo, Judith Bergada-Pijuan, Clément Vulin, Daniel A Hofmaenner, Thomas C Scheier, Sanne Hertegonne, Elena Parietti, Nataliya Miroshnikova, Pedro D Wendel Garcia, Matthias P Hilty, Philipp Karl Buehler, Reto A Schuepbach, Silvio D Brugger, Annelies S Zinkernagel
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010176 (2022)
COVID-19 displays diverse disease severities and symptoms including acute systemic inflammation and hypercytokinemia, with subsequent dysregulation of immune cells. Bacterial superinfections in COVID-19 can further complicate the disease course and a
Externí odkaz:
https://doaj.org/article/04b8749e56df4756990b9960b23bec34
Autor:
Philipp K. Buehler, Annelies S. Zinkernagel, Daniel A. Hofmaenner, Pedro David Wendel Garcia, Claudio T. Acevedo, Alejandro Gómez-Mejia, Srikanth Mairpady Shambat, Federica Andreoni, Martina A. Maibach, Jan Bartussek, Matthias P. Hilty, Pascal M. Frey, Reto A. Schuepbach, Silvio D. Brugger
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100229- (2021)
Summary: The impact of secondary bacterial infections (superinfections) in coronavirus disease 2019 (COVID-19) is not well understood. In this prospective, monocentric cohort study, we aim to investigate the impact of superinfections in COVID-19 pati
Externí odkaz:
https://doaj.org/article/db4a2e63c5514299b519150a27bff493
Autor:
Umberto Maccio, Annelies S. Zinkernagel, Srikanth Mairpady Shambat, Xiankun Zeng, Gieri Cathomas, Frank Ruschitzka, Reto A. Schuepbach, Holger Moch, Zsuzsanna Varga
Publikováno v:
EBioMedicine, Vol 63, Iss , Pp 103182- (2021)
Background: SARS-CoV-2 infection (COVID-19 disease) can induce systemic vascular involvement contributing to morbidity and mortality. SARS-CoV-2 targets epithelial and endothelial cells through the ACE2 receptor. The anatomical involvement of the cor
Externí odkaz:
https://doaj.org/article/f2c2a2ebdf2e434aa3715b9fd84ffe08
Autor:
Tiziano A Schweizer, Srikanth Mairpady Shambat, Clement Vulin, Sylvia Hoeller, Claudio Acevedo, Markus Huemer, Alejandro Gomez‐Mejia, Chun‐Chi Chang, Jeruscha Baum, Sanne Hertegonne, Eva Hitz, Thomas C Scheier, Daniel A Hofmaenner, Philipp K Buehler, Holger Moch, Reto A Schuepbach, Silvio D Brugger, Annelies S Zinkernagel
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 12, Pp n/a-n/a (2021)
Abstract Objectives Critically ill coronavirus disease 2019 (COVID‐19) patients are characterised by a severely dysregulated cytokine profile and elevated neutrophil counts, impacting disease severity. However, it remains unclear how neutrophils co
Externí odkaz:
https://doaj.org/article/7fd263ea29c7436da33567c8fe95612a