Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Srikant Viswanadha"'
Autor:
Carmelo Carlo-Stella, Antonio Sica, Paola Allavena, Armando Santoro, Luca Castagna, Swaroop Vakkalanka, Srikant Viswanadha, Akihiro Maeda, Francesca M. Consonni, Simone Serio, Giuseppa Careddu, Silvia L. Locatelli
Purpose:Tumor-associated macrophages (TAMs) and the hyperactivation of the PI3K/AKT pathway are involved in the pathogenesis of Hodgkin lymphoma and affect disease outcome. Because the δ and γ isoforms of PI3K are overexpressed in Hodgkin/Reed–St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7d9f22de652aa8ae7e09461e47760a
https://doi.org/10.1158/1078-0432.c.6526757
https://doi.org/10.1158/1078-0432.c.6526757
Autor:
Heather L Gardner, Sarah B Rippy, Misty D Bear, Kim L Cronin, Heather Heeb, Holly Burr, Claire M Cannon, Kumar V Penmetsa, Srikant Viswanadha, Swaroop Vakkalanka, Cheryl A London
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195357 (2018)
RV1001 is a novel, potent, and selective PI3Kδ inhibitor. The purpose of this study was to evaluate the safety and efficacy of RV1001 in canine Non-Hodgkin lymphoma (NHL).Inhibition of endogenous pAKT by RV1001 in primary canine NHL cells was determ
Externí odkaz:
https://doaj.org/article/2cde8c7101d8458aaeb72cfb3d0632c4
Autor:
Ajit Nair, Prajak J. Barde, Kasi V. Routhu, Srikant Viswanadha, Sridhar Veeraraghavan, Samuel Pak, Jeffrey A. Peterson, Swaroop Vakkalanka
Publikováno v:
British journal of clinical pharmacologyREFERENCES.
Dihydroorotate dehydrogenase (DHODH) is a mitochondrial enzyme that is essential for pyrimidine de novo synthesis. Rapidly growing cancer cells and replicating viruses are dependent on host cell nucleotides, the precursors of which are provided by DH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe2d7531cb05e46a0a43301679be807
https://pubmed.ncbi.nlm.nih.gov/36217901
https://pubmed.ncbi.nlm.nih.gov/36217901
Autor:
Ajit Nair, Prajak Barde, Kasiviswanath Routhu, Srikant Viswanadha, Sridhar Veeraraghavan, Swaroop Vakkalanka
RP7214 is a potent and selective inhibitor of human mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). This paper describes the results from a Phase 1 study that evaluated safety and pharmacokinetics of single and multiple ascending doses (SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5930f59feabd30bf5551afa8d2b9f66
https://doi.org/10.22541/au.165668764.44953153/v1
https://doi.org/10.22541/au.165668764.44953153/v1
Publikováno v:
Journal of Clinical Pharmacy and Therapeutics. 46:677-687
What is known and objective RP3128, a novel, orally available modulator of calcium released activated calcium (CRAC) channel, is being developed for the potential treatment of autoimmune and inflammatory diseases. RP3128 showed nano-molar potency and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880334daeec3b30b4523fa9a88e2d05f
https://doi.org/10.1111/jcpt.13322
https://doi.org/10.1111/jcpt.13322
Autor:
Srikant Viswanadha, Satyanarayana Eleswarapu, Kondababu Rasamsetti, Haritha Polimati, Sridhar Veeraraghavan, Swaroop Vakkalanka
Publikováno v:
Cancer Research. 82:5493-5493
Introduction: The Poly (ADP-ribose) polymerase (PARP) family plays an important role in the regulation of transcription, apoptosis and DNA damage response. Several PARP inhibitors have been approved for the treatment of BRCA-mutated ovarian, breast a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fd8ef58e5e6ad81680454b25bd71333
https://doi.org/10.1158/1538-7445.am2022-5493
https://doi.org/10.1158/1538-7445.am2022-5493
Publikováno v:
Cancer Research. 82:5492-5492
Background: Dihydroorotate dehydrogenase (DHODH), a rate limiting enzyme in pyrimidine synthesis, is overexpressed in certain cancers and impedes tumor cell proliferation via cell cycle arrest. RP7214 is a novel and potent DHODH inhibitor that inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2b2bff8bc00267ffd75c3f03ab86114
https://doi.org/10.1158/1538-7445.am2022-5492
https://doi.org/10.1158/1538-7445.am2022-5492
Autor:
Kari M. Wojtanik, Keith Edgemon, Srikant Viswanadha, Brigette Lindsey, Martin Haluzik, Weiping Chen, George Poy, Marc Reitman, Constantine Londos
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 6, Pp 1068-1079 (2009)
We investigated the role of LMNA in adipose tissue by developing a novel mouse model of lipodystrophy. Transgenic mice were generated that express the LMNA mutation that causes familial partial lipodystrophy of the Dunnigan type (FPLD2). The phenotyp
Externí odkaz:
https://doaj.org/article/009057fc8a974808abbaecc922eda7f8
Autor:
Srikant Viswanadha, Constantine Londos
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 8, Pp 1859-1864 (2006)
The current literature on lipolysis in murine primary adipocytes is rife with experiments performed under conditions not optimized for reproducible and reliable results. Here, we present conditions for optimizing the measurement of lipolysis in murin
Externí odkaz:
https://doaj.org/article/8db6720b1f154233ae9d74f19cb90377
Autor:
Silvia L. Locatelli, Armando Santoro, Simone Serio, Akihiro Maeda, Paola Allavena, Francesca Maria Consonni, Giuseppa Careddu, Antonio Sica, Swaroop Vakkalanka, Carmelo Carlo-Stella, Srikant Viswanadha, Luca Castagna
Publikováno v:
Clinical Cancer Research. 25:1098-1112
Purpose: Tumor-associated macrophages (TAMs) and the hyperactivation of the PI3K/AKT pathway are involved in the pathogenesis of Hodgkin lymphoma and affect disease outcome. Because the δ and γ isoforms of PI3K are overexpressed in Hodgkin/Reed–S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfa61f84218fce2c1c2e4ab8b68a596
https://doi.org/10.1158/1078-0432.ccr-18-1133
https://doi.org/10.1158/1078-0432.ccr-18-1133