Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Srikant RANGARAJU"'
Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
Autor:
Annie M. Goettemoeller, Emmie Banks, Prateek Kumar, Viktor J. Olah, Katharine E. McCann, Kelly South, Christina C. Ramelow, Anna Eaton, Duc M. Duong, Nicholas T. Seyfried, David Weinshenker, Srikant Rangaraju, Matthew J. M. Rowan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Preventative treatment for Alzheimer’s Disease (AD) is dire, yet mechanisms underlying early regional vulnerability remain unknown. In AD, one of the earliest pathophysiological correlates to cognitive decline is hyperexcitability, which i
Externí odkaz:
https://doaj.org/article/472c8a45309c4ce99d27485c1bbd846b
Autor:
Alyssa F. Pybus, Sara Bitarafan, Rowan O. Brothers, Alivia Rohrer, Arushi Khaitan, Felix Rivera Moctezuma, Kareena Udeshi, Brae Davies, Sydney Triplett, Martin N. Griffin, Eric B. Dammer, Srikant Rangaraju, Erin M. Buckley, Levi B. Wood
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can result in long term cognitive deficits, depression, and eventual neurodegeneration associated with tau pathology, amyloid beta (Aβ) plaques, gli
Externí odkaz:
https://doaj.org/article/33fb43db821e412cb4a51344d8ea1517
Autor:
Prateek Kumar, Annie M. Goettemoeller, Claudia Espinosa-Garcia, Brendan R. Tobin, Ali Tfaily, Ruth S. Nelson, Aditya Natu, Eric B. Dammer, Juliet V. Santiago, Sneha Malepati, Lihong Cheng, Hailian Xiao, Duc D. Duong, Nicholas T. Seyfried, Levi B. Wood, Matthew J. M. Rowan, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-26 (2024)
Abstract Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally
Externí odkaz:
https://doaj.org/article/4a3d7575d66340e7b52ba0e5a848ab2b
Autor:
Mohamed A. Tarek, Mateus Damiani, Mahmoud H. Mohammaden, Srikant Rangaraju, Pedro N. Martins, Jay N. Dolia, Aqueel A. Pabaney, Jonathan R. Grossberg, Michael Nahhas, Alhamza R. Nogueira, Raul G. Haussen
Publikováno v:
Stroke: Vascular and Interventional Neurology, Vol 3, Iss S2 (2023)
Introduction Intracranial atherosclerotic disease (ICAD) is one of the leading causes of ischemic stroke. We sought to identify variables associated with ICAD underlying large vessel occlusion strokes (LVOS) to facilitate pre‐procedural diagnosis.
Externí odkaz:
https://doaj.org/article/6a8e8a5f06fc48918c0aeac204e4b27c
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/f8d6e97f2d4044129c4c14a85cc6b874
Autor:
Fadi Nahab, Rana Bayakly, Mary Elizabeth Sexton, Manet Lemuel-Clarke, Laura Henriquez, Srikant Rangaraju, Moges Ido
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundThe objective of our study was to evaluate vaccine type, COVID-19 infection, and their association with stroke soon after COVID-19 vaccination.MethodsIn a retrospective cohort study, we estimated the 21-day post-vaccination incidence of str
Externí odkaz:
https://doaj.org/article/2121ce0349c24e08a03d3f773605dcae
Autor:
Erming Wang, Allen L. Pan, Pritha Bagchi, Srikant Rangaraju, Nicholas T. Seyfried, Michelle E. Ehrlich, Stephen R. Salton, Bin Zhang
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 66 (2024)
DUSP4 is a member of the DUSP (dual-specificity phosphatase) subfamily that is selective to the mitogen-activated protein kinases (MAPK) and has been implicated in a range of biological processes and functions in Alzheimer’s disease (AD). In this s
Externí odkaz:
https://doaj.org/article/fecc5e04b41a42928c245a146df2ef3e
Autor:
Meghan E Wynne, Oluwaseun Ogunbona, Alicia R Lane, Avanti Gokhale, Stephanie A Zlatic, Chongchong Xu, Zhexing Wen, Duc M Duong, Sruti Rayaprolu, Anna Ivanova, Eric A Ortlund, Eric B Dammer, Nicholas T Seyfried, Blaine R Roberts, Amanda Crocker, Vinit Shanbhag, Michael Petris, Nanami Senoo, Selvaraju Kandasamy, Steven Michael Claypool, Antoni Barrientos, Aliza Wingo, Thomas S Wingo, Srikant Rangaraju, Allan I Levey, Erica Werner, Victor Faundez
Publikováno v:
eLife, Vol 12 (2023)
Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we demonstrate that mitochondrial regulation of the secretome is more extensive tha
Externí odkaz:
https://doaj.org/article/f59364e09ba749e59bd95488824ad15b
Autor:
Digvijaya Navalkele, Srikant Rangaraju, Meghana Srinivas, Justine Chen, Bianca Nemes, Nicolas Bianchi, Ritvij Bowry, Carol Flemming, Stephanie Parker, James Grotta, Michael Frankel
Publikováno v:
Stroke: Vascular and Interventional Neurology, Vol 3, Iss S1 (2023)
Introduction Spontaneous intracranial hemorrhage (ICH) is associated with significant morbidity and mortality. Mobile Stroke Unit (MSU) provides a unique opportunity to assess patients in the hyperacute phase of ICH to track outcomes. Methods Methods
Externí odkaz:
https://doaj.org/article/96628e8898bc4c6595b5da2066f34c9b
Autor:
Sruti Rayaprolu, Sara Bitarafan, Juliet V. Santiago, Ranjita Betarbet, Sydney Sunna, Lihong Cheng, Hailian Xiao, Ruth S. Nelson, Prateek Kumar, Pritha Bagchi, Duc M. Duong, Annie M. Goettemoeller, Viktor János Oláh, Matt Rowan, Allan I. Levey, Levi B. Wood, Nicholas T. Seyfried, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Current isolation-based approaches for cell type-specific proteomics pose several challenges. Here, the authors present an approach for in vivo cell type-specific protein labeling to characterize proteomic differences between neurons and astrocytes i
Externí odkaz:
https://doaj.org/article/0366b13af39b4d438b5baee2a2a9c33d