Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Srijana Pokhrel"'
Autor:
Kaitlin A. Read, Devin M. Jones, Srijana Pokhrel, Emily D. S. Hales, Aditi Varkey, Jasmine A. Tuazon, Caprice D. Eisele, Omar Abdouni, Abbey Saadey, Melissa R. Leonard, Robert T. Warren, Michael D. Powell, Jeremy M. Boss, Emily A. Hemann, Jacob S. Yount, Gang Xin, Hazem E. Ghoneim, Chan-Wang J. Lio, Aharon G. Freud, Patrick L. Collins, Kenneth J. Oestreich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
The regulation and direction of CD4+ T cells into phenotypic and functional lineages is coordinated by a complex set of mechanisms. Here the authors show a role for Aiolos as a regulator of the CD4+ cytotoxic and T follicular helper lineages.
Externí odkaz:
https://doaj.org/article/db3616878fde4edbb2df4e62fd0817bd
Autor:
Seth M. Daly, Jason A. Joyner, Kathleen D. Triplett, Bradley O. Elmore, Srijana Pokhrel, Kathryn M. Frietze, David S. Peabody, Bryce Chackerian, Pamela R. Hall
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs) and mounting antibiotic resistance requires innovative treatment strategies. S. aureus uses secreted cyclic autoinducing peptides (AIPs) and the accessory
Externí odkaz:
https://doaj.org/article/0a232fa239de454899538bbde3d06141
Autor:
Saravanan Ramakrishnan, Srijana Pokhrel, Sowmiya Palani, Christian Pflueger, Timothy J. Parnell, Bradley R. Cairns, Srividya Bhaskara, Mahesh B. Chandrasekharan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Histone H3K4 methylation affects gene transcription from yeast to humans. Here, the authors show that Set1 and Jhd2, the only H3K4 methyltransferase and H3K4 demethylase, respectively, in budding yeast, co-regulate both positive and negative transcri
Externí odkaz:
https://doaj.org/article/c625e8ba26fc4e15b485691b7990fe44
Autor:
Jason A. Joyner, Seth M. Daly, Julianne Peabody, Kathleen D. Triplett, Srijana Pokhrel, Bradley O. Elmore, Diane Adebanjo, David S. Peabody, Bryce Chackerian, Pamela R. Hall
Publikováno v:
Toxins, Vol 12, Iss 7, p 450 (2020)
The pore-forming cytotoxin α-hemolysin, or Hla, is a critical Staphylococcus aureus virulence factor that promotes infection by causing tissue damage, excessive inflammation, and lysis of both innate and adaptive immune cells, among other cellular t
Externí odkaz:
https://doaj.org/article/5ab62e5abd8c427baeac27586ffea8b1
Autor:
Prakash K Shukla, Jesse E Bissell, Sanjit Kumar, Srijana Pokhrel, Sowmiya Palani, Kaitlin S Radmall, Onyeka Obidi, Timothy J Parnell, Julia Brasch, Dennis C Shrieve, Mahesh B Chandrasekharan
Publikováno v:
Nucleic Acids Research. 51:2117-2136
The conserved complex of the Rad6 E2 ubiquitin-conjugating enzyme and the Bre1 E3 ubiquitin ligase catalyzes histone H2B monoubiquitination (H2Bub1), which regulates chromatin dynamics during transcription and other nuclear processes. Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::295242219c2cb3386b98322ed1b1ae19
https://doi.org/10.1093/nar/gkad012
https://doi.org/10.1093/nar/gkad012
Autor:
Jason A. Joyner, Pamela R. Hall, Geetanjali Sharma, Srijana Pokhrel, Matthew J. Campen, Seth M. Daly, Guy Herbert, Moriah J. Castleman, Kathleen D. Triplett, Helen J. Hathaway, Bradley O. Elmore, Eric R. Prossnitz
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Sex bias in innate defense against Staphylococcus aureus skin and soft tissue infection (SSTI) is dependent on both estrogen production by the host and S. aureus secretion of the virulence factor, α-hemolysin (Hla). The impact of estrogen signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c63e39ee7bd11675372e67123c5afd
http://link.springer.com/article/10.1038/s41598-018-37951-3
http://link.springer.com/article/10.1038/s41598-018-37951-3
Autor:
Srijana Pokhrel, Kaitlin A Read, Devin M Jones, Michael D Powell, Robert T Warren, Kenneth J Oestreich
Publikováno v:
The Journal of Immunology. 208:57.04-57.04
CD4+ central memory T cells (TCM) are key players in recall immune responses and thus are critical to long-term immunity. Despite their importance, much remains to be defined regarding the mechanisms that promote their differentiation and survival. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fffe1c5407f453b9a3e8e8c882a4d60d
https://doi.org/10.4049/jimmunol.208.supp.57.04
https://doi.org/10.4049/jimmunol.208.supp.57.04
Autor:
Kaitlin Read, Srijana Pokhrel, Devin M Jones, Abbey Saadey, Caprice Eisele, Robert T Warren, Patrick Collins, Hazem E. Ghoneim, Aharon Freud, Kenneth J Oestreich
Publikováno v:
The Journal of Immunology. 208:112.20-112.20
CD4+ T follicular helper (TFH) cells are critical for the generation of robust humoral immune responses, as they provide help to B cells to support the generation of both pathogen-neutralizing antibodies and long-lived plasma cell populations. To dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e48c2faf28862dbebfe04315c47d509
https://doi.org/10.4049/jimmunol.208.supp.112.20
https://doi.org/10.4049/jimmunol.208.supp.112.20
Autor:
Devin M Jones, Kaitlin A Read, Srijana Pokhrel, Emily Hales, Caprice Eisele, Robert T Warren, Patrick Collins, Aharon Freud, Kenneth J Oestreich
Publikováno v:
The Journal of Immunology. 208:166.03-166.03
Classically, CD4+ T cells have been defined as “helper” type cells, providing aid to other immune cell populations via the secretion of cytokines and direct cell-cell interactions. More recently, a subset of CD4+ T cells with cytotoxic capabiliti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f68a70c96a759f8ee2e5469f49a5f2c
https://doi.org/10.4049/jimmunol.208.supp.166.03
https://doi.org/10.4049/jimmunol.208.supp.166.03
Autor:
Kathleen D. Triplett, Bradley O. Elmore, David S. Peabody, Jason A. Joyner, Bryce Chackerian, Diane Adebanjo, Pamela R. Hall, Seth M. Daly, Srijana Pokhrel, Julianne Peabody
Publikováno v:
Toxins
Volume 12
Issue 7
Toxins, Vol 12, Iss 450, p 450 (2020)
Volume 12
Issue 7
Toxins, Vol 12, Iss 450, p 450 (2020)
The pore-forming cytotoxin &alpha
hemolysin, or Hla, is a critical Staphylococcus aureus virulence factor that promotes infection by causing tissue damage, excessive inflammation, and lysis of both innate and adaptive immune cells, among other c
hemolysin, or Hla, is a critical Staphylococcus aureus virulence factor that promotes infection by causing tissue damage, excessive inflammation, and lysis of both innate and adaptive immune cells, among other c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19d0894fc6abe503cdb3afb613c7931
http://europepmc.org/articles/PMC7404987
http://europepmc.org/articles/PMC7404987