Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Sridharan, Raghavan"'
Autor:
Katherine G. Young, Eram Haider McInnes, Robert J. Massey, Anna R. Kahkoska, Scott J. Pilla, Sridharan Raghavan, Maggie A. Stanislawski, Deirdre K. Tobias, Andrew P. McGovern, Adem Y. Dawed, Angus G. Jones, Ewan R. Pearson, John M. Dennis, ADA/EASD PDMI
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-20 (2023)
Abstract Background A precision medicine approach in type 2 diabetes requires the identification of clinical and biological features that are reproducibly associated with differences in clinical outcomes with specific anti-hyperglycaemic therapies. R
Externí odkaz:
https://doaj.org/article/992adc09888640ada251a7a6fb48b3d5
Autor:
Jie Huang, Jennifer E. Huffman, Yunfeng Huang, Ítalo Do Valle, Themistocles L. Assimes, Sridharan Raghavan, Benjamin F. Voight, Chang Liu, Albert-László Barabási, Rose D. L. Huang, Qin Hui, Xuan-Mai T. Nguyen, Yuk-Lam Ho, Luc Djousse, Julie A. Lynch, Marijana Vujkovic, Catherine Tcheandjieu, Hua Tang, Scott M. Damrauer, Peter D. Reaven, Donald Miller, Lawrence S. Phillips, Maggie C. Y. Ng, Mariaelisa Graff, Christopher A. Haiman, Ruth J. F. Loos, Kari E. North, Loic Yengo, George Davey Smith, Danish Saleheen, J. Michael Gaziano, Daniel J. Rader, Philip S. Tsao, Kelly Cho, Kyong-Mi Chang, Peter W. F. Wilson, VA Million Veteran Program, Yan V. Sun, Christopher J. O’Donnell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Elevated body mass index is heritable and associated with many health conditions that impact morbidity and mortality. Here, the authors identify greater than 900 genetic loci for body mass index (BMI) and find over 300 diagnoses associated with incre
Externí odkaz:
https://doaj.org/article/06e868b6d30b40ac93e6e40a0445cc48
Autor:
Justin A. Edward, Kevin Josey, Gideon Bahn, Liron Caplan, Jane E. B. Reusch, Peter Reaven, Debashis Ghosh, Sridharan Raghavan
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-11 (2022)
Abstract Background Evidence to guide type 2 diabetes treatment individualization is limited. We evaluated heterogeneous treatment effects (HTE) of intensive glycemic control in type 2 diabetes patients on major adverse cardiovascular events (MACE) i
Externí odkaz:
https://doaj.org/article/42f7aba1d899418f9f74d6b85c7cc1df
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100830- (2023)
Purpose: Little is known about non-genetics health care specialists’ attitudes toward the return and utilization of actionable genomic results from a research biobank. We surveyed primary care providers (PCPs) to explore their perspectives on these
Externí odkaz:
https://doaj.org/article/3375453bf6864a02bd0be1f28a5d32cc
Autor:
Melissa P. Wilson, David A. Mayer, Luke V. Rasmussen, Pramod Khanal, Maryam Nuriyeva, Michael McRae, Sridharan Raghavan, Laura K. Wiley
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 98-99 (2023)
OBJECTIVES/GOALS: The rates of computational phenotyping algorithm reuse across health systems are low, leading to a proliferation of algorithms for the same trait. We propose a framework for reusing computational phenotyping algorithms and describe
Externí odkaz:
https://doaj.org/article/d2e8bccb5f794ddb8df4fbb42fbf348d
Autor:
Maggie A. Stanislawski, Elizabeth Litkowski, Ruby Fore, Sheryl L. Rifas-Shiman, Emily Oken, Marie-France Hivert, Ethan M. Lange, Leslie A. Lange, Dana Dabelea, Sridharan Raghavan
Publikováno v:
Pediatric Reports, Vol 13, Iss 2, Pp 279-288 (2021)
To examine whether BMI-associated genetic risk variants modify the association of intrauterine diabetes exposure with childhood BMI z-scores, we assessed the interaction between 95 BMI-associated genetic variants and in utero exposure to maternal dia
Externí odkaz:
https://doaj.org/article/b7d9d4d201d74ee1a40702b5ee868514
Autor:
Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E. Huffman, Elizabeth Litkowski, Chang Liu, Yuk-Lam A. Ho, Haley Hunter-Zinck, Hongyu Zhao, Eirini Marouli, Kari E. North, the VA Million Veteran Program, Ethan Lange, Leslie A. Lange, Benjamin F. Voight, J. Michael Gaziano, Saiju Pyarajan, Elizabeth R. Hauser, Philip S. Tsao, Peter W. F. Wilson, Kyong-Mi Chang, Kelly Cho, Christopher J. O’Donnell, Yan V. Sun, Themistocles L. Assimes
Publikováno v:
PLoS Genetics, Vol 18, Iss 6 (2022)
Background Height has been associated with many clinical traits but whether such associations are causal versus secondary to confounding remains unclear in many cases. To systematically examine this question, we performed a Mendelian Randomization-Ph
Externí odkaz:
https://doaj.org/article/67d57c9c70724376babc536043d7ef77
Autor:
Vinay Kini, Bridget Mosley, Sridharan Raghavan, Prateeti Khazanie, Steven M. Bradley, David J. Magid, P. Michael Ho, Frederick A. Masoudi
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 3 (2021)
Background Quality of care incentives and reimbursements for cardiovascular testing differ between insurance providers. We hypothesized that there are differences in the use of guideline‐concordant testing between Medicaid versus commercial insuran
Externí odkaz:
https://doaj.org/article/2787e7efb6d248b0a308509a19c0964c
Autor:
Peitao Wu, Denis Rybin, Lawrence F Bielak, Mary F Feitosa, Nora Franceschini, Yize Li, Yingchang Lu, Jonathan Marten, Solomon K Musani, Raymond Noordam, Sridharan Raghavan, Lynda M Rose, Karen Schwander, Albert V Smith, Salman M Tajuddin, Dina Vojinovic, Najaf Amin, Donna K Arnett, Erwin P Bottinger, Ayse Demirkan, Jose C Florez, Mohsen Ghanbari, Tamara B Harris, Lenore J Launer, Jingmin Liu, Jun Liu, Dennis O Mook-Kanamori, Alison D Murray, Mike A Nalls, Patricia A Peyser, André G Uitterlinden, Trudy Voortman, Claude Bouchard, Daniel Chasman, Adolfo Correa, Renée de Mutsert, Michele K Evans, Vilmundur Gudnason, Caroline Hayward, Linda Kao, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, Michael M Province, Tuomo Rankinen, Susan Redline, Paul M Ridker, Jerome I Rotter, David Siscovick, Blair H Smith, Cornelia van Duijn, Alan B Zonderman, D C Rao, James G Wilson, Josée Dupuis, James B Meigs, Ching-Ti Liu, Jason L Vassy
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0230815 (2020)
Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide interaction studies to ide
Externí odkaz:
https://doaj.org/article/2b6f95449b6b4935b0d4624e65bfbe83
Publikováno v:
Statistics in Medicine. 41:4511-4531
Two important considerations in clinical research studies are proper evaluations of internal and external validity. While randomized clinical trials can overcome several threats to internal validity, they may be prone to poor external validity. Conve