Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats

Autor: Ravindra Babu Pingili, Sridhar Vemulapalli, Surya Sandeep Mullapudi, Vijaya R. Dirisala, Harsha Sai Chanumolu, Naveen Babu Kilaru

Publikováno v: Future Journal of Pharmaceutical Sciences, Vol 9, Iss 1, Pp 1-8 (2023)

Abstract Background Metoprolol is a substrate of CYP3A4, 2B6, CYP2D6, CYP2C9, and p-glycoprotein (p-gp). Hesperetin was reported as an inhibitor of cytochrome P-450 (CYP) enzymes and p-gp. The objective of this study was to investigate the effect of

Externí odkaz: https://doaj.org/article/c5625190684e4e7998179bb52df98769

INFLUENCE OF POMEGRANATE JUICE ON THE CYP3A4-MEDIATED METABOLISM AND P-GLYCOPROTEIN MEDIATED TRANSPORT OF SAQUINAVIR IN VIVO AND EX VIVO MODELS

Autor: Sridhar Vemulapalli, Surya Sandeep Mullapudi, Ravindrababu Pingili, Ramya Kothapalli, Sivaramakrishna Kondru, Naveenbabu Kilaru

Publikováno v: Indonesian Journal of Pharmacy, Vol 27, Iss 3, Pp 152-162 (2016)

Cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) play an important role in the first pass metabolism thereby limits the oral bioavailability of many clinically important and frequently prescribed drugs. The absolute oral bioavailability of saqu

Externí odkaz: https://doaj.org/article/4c08deab6960498fb97ae637de7f71bc

Assembly of Synaptic Protein-DNA Complexes: Critical Role of Non-Specific Interactions

Autor: Sridhar Vemulapalli, Mohtadin Hashemi, Anatoly B. Kolomeisky, Yuri L. Lyubchenko

The synaptic protein-DNA complexes, formed by specialized proteins that bridge two or more distant sites on DNA, are critically involved in various genetic processes. However, the molecular mechanism by which the protein searches for these sites and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fea553d388d43dea10df989b7277d7a
https://doi.org/10.1101/2023.04.27.538641

Effect of herbal bioenhancer (naringenin) on the pharmacokinetics of diltiazem in rats via CYP3A4 and P-glycoprotein inhibition

Autor: Ravindra Babu Pingili, Sridhar Vemulapalli, Surya Sandeep Mullapudi, Krishna Mohan Chinnala, Naveen Babu Kilaru

Publikováno v: Annals of Phytomedicine: An International Journal. 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0971e3e10e34c3aa16e456ad176bafbf
https://doi.org/10.54085/ap.2022.11.2.80

Site-Search Process for Synaptic Protein-DNA Complexes

Autor: Sridhar Vemulapalli, Mohtadin Hashemi, Yuri L. Lyubchenko

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 212
International Journal of Molecular Sciences, Vol 23, Iss 212, p 212 (2022)

The assembly of synaptic protein-DNA complexes by specialized proteins is critical for bringing together two distant sites within a DNA molecule or bridging two DNA molecules. The assembly of such synaptosomes is needed in numerous genetic processes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42e73f2e6417a5fc87d0ad2de550c48
https://pubmed.ncbi.nlm.nih.gov/35008637