Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Sridhar Varadarajan"'
Autor:
S Prasad Gabbita, Ming F Johnson, Naomi Kobritz, Pirooz Eslami, Aleksandra Poteshkina, Sridhar Varadarajan, John Turman, Frank Zemlan, Marni E Harris-White
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0137305 (2015)
Cytokines such as TNFα can polarize microglia/macrophages into different neuroinflammatory types. Skewing of the phenotype towards a cytotoxic state is thought to impair phagocytosis and has been described in Alzheimer's Disease (AD). Neuroinflammat
Externí odkaz:
https://doaj.org/article/fd961e848a2a41678b775a2c63ae7d6b
Autor:
Manoj Chelvanambi, Matthew Powell, Connor B Cribb, Donald P. McDonnell, Rigel J. Kishton, Phat T Do, Leah L Lowder, Sridhar Varadarajan, Kelly Mastro-Kishton, Giridhar R. Akkaraju, Sean E. Miller, Libero J. Bartolotti, Suzanne E. Wardell, Charles B. Kelly, Rajeshwar Reddy Govindapur, Arthur R. Frampton
Publikováno v:
Journal of Medicinal Chemistry. 64:12651-12669
We previously described the development of a DNA-alkylating compound that showed selective toxicity in breast cancer cells. This compound contained an estrogen receptor α (ERα)-binding ligand and a DNA-binding/methylating component that could selec
[Image: see text] N3-Methyl-2′-deoxyadenosine (MdA) is the major dA methylation product in duplex DNA. MdA blocks DNA replication and undergoes depurination at significantly higher rates than the native nucleotide from which it is derived. Recent r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d3b87fcacd082c98e99f158ddd96c8
https://europepmc.org/articles/PMC6803048/
https://europepmc.org/articles/PMC6803048/
Autor:
Charles B. Kelly, Libero J. Bartolotti, Mairin K. Buchanan, Tyler J. Goodwin, Andrew L. McIver, Arthur R. Frampton, Maria C. White, Andrea J. Bourdelais, Lacie M. Chauvigné-Hines, Nina E. Neill, Kelly Mastro-Kishton, Sridhar Varadarajan, Chase N. Needham
Publikováno v:
Biochemistry. 56(2)
DNA-alkylating drugs continue to remain an important weapon in the arsenal against cancers. However, they typically suffer from several shortcomings because of the indiscriminate DNA damage that they cause and their inability to specifically target c
Autor:
Mayur Patel, Heather Perry, Vinayak K. Gore, Rigel J. Kishton, Giridhar R. Akkaraju, Sridhar Varadarajan, Sean E. Miller, Tera Lynch
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:5093-5102
A compound that can target cells expressing the estrogen receptor (ER), and produce predominantly 3-MeA adducts in those cells has been designed and synthesized. This compound produces mainly the 3-MeA adduct upon reaction with calf thymus DNA, and b
Publikováno v:
Journal of Molecular Structure: THEOCHEM. 894:50-58
Me-lex, {1-methyl-4-[1-methyl-4-[3-(methoxysulfonyl)-propanamido]pyrrole-2-carboxamido]pyrrole-2-carboxamido}-propane}, a neutral methyl sulfonate analog of netropsin lacking the cationic tails, methylates adenines in the minor groove of DNA at the s
Publikováno v:
Multimedia Systems. 14:73-87
With broadcast Television (TV) going digital, the number of channels and the programs aired have increased tremendously. Millions of audiences of various categories such as adults, children, youth and families watch these programs. Advertisements (ad
Autor:
Ryan D. Goff, John R. Silber, Douglas D. Kolstoe, Barry Gold, Michael S. Bobola, A. Blank, Sridhar Varadarajan, Nolan W Smith
Publikováno v:
Clinical Cancer Research. 13:612-620
Purpose: Defining the cytotoxicity of individual adducts in DNA is necessary for mechanistic understanding of human brain tumor resistance to therapeutic alkylating agents and for design of DNA repair-related antiresistance strategies. Our purpose is
Autor:
Marni E. Harris-White, Ming F. Johnson, Pirooz Eslami, S. Prasad Gabbita, John Turman, Sridhar Varadarajan, Naomi Kobritz, Aleksandra Poteshkina, Frank P. Zemlan
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0137305 (2015)
PLoS ONE
PLoS ONE
Cytokines such as TNFα can polarize microglia/macrophages into different neuroinflammatory types. Skewing of the phenotype towards a cytotoxic state is thought to impair phagocytosis and has been described in Alzheimer’s Disease (AD). Neuroinflamm
Autor:
A. Blank, Douglas D. Kolstoe, Lawrence A. Loeb, Barry Gold, Michael S. Bobola, Sridhar Varadarajan, Elizabeth H. Meade, John R. Silber, Peter S. Rabinovitch
Publikováno v:
DNA Repair. 3:629-638
The Werner syndrome (WS) protein (WRN), a DNA helicase/exonuclease, is required for genomic stability and avoidance of cancer. Current evidence suggests that WRN is involved in the resolution of stalled and/or collapsed replication forks. This functi