Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sridhar Santhanakrishnan"'
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Mycobacteria harbor two main degradative proteolytic machineries, the caseinolytic protease ClpP1P2 and a proteasome. We recently showed that Bortezomib inhibits ClpP1P2 and exhibits whole cell activity against Mycobacterium tuberculosis. Bortezomib,
Externí odkaz:
https://doaj.org/article/c51e868a4b1a4fcdb6353893f7488139
Autor:
Roderick W. Bates, Sridhar Santhanakrishnan, Julien Lescar, Abbas El Sahili, Subhash G. Vasudevan, Siok Thing Tan, Yee Hwa Wong, Aïcha Gharbi-Ayachi, Kitti Wing Ki Chan
Publikováno v:
J Virol
Zika virus (ZIKV) remains a potentially significant public health concern because it can cause teratogenic effects, such as microcephaly in newborns and neurological disease, like Guillain-Barre syndrome. Together with efforts to develop a vaccine, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a223d849ddbbc074ec887748c51cffb5
https://europepmc.org/articles/PMC7565630/
https://europepmc.org/articles/PMC7565630/
Publikováno v:
Polymer. 116:5-15
Deposition of polydopamine on substrates is a facile and effective method of surface modification and the deposited polydopamine can reduce silver ions to form silver nanoparticles (AgNPs) for antibacterial applications. However, polydopamine deposit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4c94a061633b31bac8dc03f4725f6bc
https://doi.org/10.1016/j.polymer.2017.03.061
https://doi.org/10.1016/j.polymer.2017.03.061
Autor:
Koon Gee Neoh, Sridhar Santhanakrishnan, Yong Shung Cheah, Christina L. L. Chai, Liya Shi, Min Li
Publikováno v:
ACS Applied Materials & Interfaces. 8:33131-33138
Dopamine (DA) protected by an o-nitrobenzyl functionality on its phenolic group was synthesized as a photolabile catecholamine derivative. This compound, o-nitrobenzyl dopamine (NBDA), was more stable than DA in basic solution at pH 8.5 and will not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7355433fe2a715e831443b4418c037
https://doi.org/10.1021/acsami.6b07751
https://doi.org/10.1021/acsami.6b07751
Autor:
Wilfried Moreira, Sridhar Santhanakrishnan, Anders Poulsen, Thomas Dick, Brian W. Dymock, Grace J. Y. Ngan, Kanda Sangthongpitag, Choon Bing Low
Publikováno v:
Antimicrobial Agents and Chemotherapy
Mycobacterium tuberculosis is responsible for the greatest number of deaths worldwide due to a bacterial agent. We recently identified bortezomib (Velcade; compound 1) as a promising antituberculosis (anti-TB) compound. We showed that compound 1 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6e30bb8107b8a9b7ff0750396ce22e
http://europepmc.org/articles/PMC5404560
http://europepmc.org/articles/PMC5404560
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 8 (2017)
Frontiers in Microbiology, Vol 8 (2017)
Mycobacteria harbor two main degradative proteolytic machineries, the caseinolytic protease ClpP1P2 and a proteasome. We recently showed that Bortezomib inhibits ClpP1P2 and exhibits whole cell activity against Mycobacterium tuberculosis. Bortezomib,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4f6977dcc48a6eeb40226bcda95694
http://europepmc.org/articles/PMC5406460
http://europepmc.org/articles/PMC5406460
Autor:
Sridhar Santhanakrishnan, Tiong Wei Tan, Eric Tam, Zhimei Li, Sze Yue Wong, Cheryl Zi Hui Lim, Yi Ling Goh, Christina L. L. Chai, Tuan Minh Nguyen, Esther H. Q. Ong, Jeffrey Hill, Qiang Yu, Haiyan Yang, Xia Jiang, Puay Leng Lee
Publikováno v:
ChemMedChem. 10:173-182
3-Deazaneplanocin A (DzNep) is a potential epigenetic drug for the treatment of various cancers. DzNep has been reported to deplete histone methylations, including oncogenic EZH2 complex, giving rise to epigenetic modifications that reactivate many s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d79c60c92330be31558cb330b5a6c1
https://doi.org/10.1002/cmdc.201402315
https://doi.org/10.1002/cmdc.201402315
Autor:
Sridhar Santhanakrishnan, Yi Ling Goh, Zhengqiu Li, Eric Tam, Sze Yue Wong, Shao Q. Yao, Xiamin Cheng, Christina L. L. Chai
Publikováno v:
Chemistry - An Asian Journal. 8:1818-1828
3-Deazaneplanocin A (DzNep), a global histone methylation inhibitor, has attracted significant interest in epigenetic research in recent years. The molecular mechanism of action and the cellular off-targets of DzNep, however, are still not well-under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ffd3dfa101199e318f402f28058fb9
https://doi.org/10.1002/asia.201300303
https://doi.org/10.1002/asia.201300303
Publikováno v:
ChemInform. 46
The ester (I), readily available from D-ribose, is transformed under optimized conditions to the stereodefined cyclopentene intermediate (II).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f725abf5a688a57c7afa4fbb539bc3c
https://doi.org/10.1002/chin.201510276
https://doi.org/10.1002/chin.201510276
Publikováno v:
The Journal of organic chemistry. 79(17)
The key cyclopentenyl intermediate 11b was synthesized in 4 steps from d-ribose in 41% overall yield via an efficient intramolecular Baylis–Hillman reaction. This novel key intermediate can be modified easily and transformed to neplanocin A (1a) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce087b9d389e7f2ad45068ee453b611
https://pubmed.ncbi.nlm.nih.gov/25122518
https://pubmed.ncbi.nlm.nih.gov/25122518