Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sridhar Raghavachari"'
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 5, p e1000780 (2010)
One mechanism of information storage in neurons is believed to be determined by the strength of synaptic contacts. The strength of an excitatory synapse is partially due to the concentration of a particular type of ionotropic glutamate receptor (AMPA
Externí odkaz:
https://doaj.org/article/8ed3a7458c3142f9b3bcbdc76dadb9f6
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 4 (2010)
In most natural decision contexts, the process of selecting among competing actions takes place in the presence of informative, but potentially ambiguous, stimuli. Decisions about magnitudes—quantities like time, length, and brightness that are lin
Externí odkaz:
https://doaj.org/article/32c127e095014302b98b36390f2c3636
Autor:
David M Santucci, Sridhar Raghavachari
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 10, p e1000208 (2008)
N-Methyl-D-aspartic acid (NMDA) receptors are widely expressed in the brain and are critical for many forms of synaptic plasticity. Subtypes of the NMDA receptor NR2 subunit are differentially expressed during development; in the forebrain, the NR2B
Externí odkaz:
https://doaj.org/article/8e927ab5d4ec43f8875e3a44524b3c21
Publikováno v:
Molecular Biology of the Cell
The spread of Cdc42 activation at dendritic spines is modeled by means of reaction-diffusion equations solved on spine-like geometries. Excitable behavior arising from positive feedback in Cdc42 activation leads to traveling waves of Cdc42 activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffda26ec1f672f96cd284d29a07f56b
https://doi.org/10.1091/mbc.e15-06-0405
https://doi.org/10.1091/mbc.e15-06-0405
Publikováno v:
Neuron. 78(4):615-622
SummaryScaffolding molecules at the postsynaptic membrane form the foundation of excitatory synaptic transmission by establishing the architecture of the postsynaptic density (PSD), but the small size of the synapse has precluded measurement of PSD o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b26461db5982cf5615d0a67d99bd11f
Publikováno v:
Nature Reviews Neuroscience. 13:169-182
Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for long periods, making it a probable mechanism for memory storage. LTP induction results in calcium entry, which activates calcium–calmodulin-dependent protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24aad755031e389acb76b9eec266b31
https://doi.org/10.1038/nrn3192
https://doi.org/10.1038/nrn3192
Publikováno v:
Nature neuroscience
Many forms of signal transduction occur when Ca(2+) enters the cytoplasm of a cell. It has been generally thought that there is a fast buffer that rapidly reduces the free Ca(2+) level and that it is this buffered level of Ca(2+) that triggers downst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efbd74ab37cf738377b80767286415d
http://europepmc.org/articles/PMC3057387
http://europepmc.org/articles/PMC3057387
Autor:
Sridhar Raghavachari, Christos Constantinidis, Xiao Jing Wang, Jesper Tegnér, Matthew V. Chafee, Patricia S. Goldman-Rakic, Albert Compte
Publikováno v:
Journal of Neurophysiology. 90:3441-3454
An important question in neuroscience is whether and how temporal patterns and fluctuations in neuronal spike trains contribute to information processing in the cortex. We have addressed this issue in the memory-related circuits of the prefrontal cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4ca0b93820be208a26bb7c353d79e8
https://doi.org/10.1152/jn.00949.2002
https://doi.org/10.1152/jn.00949.2002
Publikováno v:
Journal of Neurophysiology. 86:368-380
We examine how oscillations in the intracranial electroencephalogram (iEEG) relate to human maze learning. Theta- band activity (4–12 Hz in rodents; 4–8 Hz in humans) plays a significant role in memory function in rodents and in humans. Recording
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412f7cc6b80c403bbce2856c1f18d9cb
https://doi.org/10.1152/jn.2001.86.1.368
https://doi.org/10.1152/jn.2001.86.1.368
Autor:
John E. Lisman, Blaise F. D. Bourgeois, Michael J. Kahana, Jeremy B. Caplan, Matthew P. Kirschen, Sridhar Raghavachari, Daniel S. Rizzuto, Joseph R. Madsen
Publikováno v:
The Journal of Neuroscience. 21:3175-3183
Electrode grids on the cortical surface of epileptic patients provide a unique opportunity to observe brain activity with high temporal–spatial resolution and high signal-to-noise ratio during a cognitive task. Previous work showed that large-ampli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a7280570ffa57903b41134fe280f41
https://doi.org/10.1523/jneurosci.21-09-03175.2001
https://doi.org/10.1523/jneurosci.21-09-03175.2001