Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Sridhar Narayan"'
Autor:
Sarah J. Mahoney, Sridhar Narayan, Lisa Molz, Lauren A. Berstler, Seong A. Kang, George P. Vlasuk, Eddine Saiah
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Aberrant mTORC1 signaling is linked to several chronic diseases. Here, the authors develop a small molecule inhibitor that binds the small G-protein Rheb and selectively blocks mTORC1 signaling, holding potential for therapeutic applications.
Externí odkaz:
https://doaj.org/article/e4e93d6c676242c793f6e0e9b9280186
Autor:
Jeffrey Ashe, John Graf, Radhika Madhavan, Kirk Wallace, Victoria Cotero, Samantha Abate, Ram Krishna Pandey, Raimund Herzog, Porindla Sridhar Narayan, David Shoudy, Ying Fan, Tzu-Jen Kao, Chris Puleo
Publikováno v:
QJM: An International Journal of Medicine.
Background Mechanical waves produced by ultrasound pulses have been shown to activate mechanosensitive ion channels and modulate peripheral nerves. However, while peripheral ultrasound neuromodulation has been demonstrated in vitro and in pre-clinica
Autor:
Emilie Giaime, George P. Vlasuk, Jessica J. Howell, Shomit Sengupta, Seung Hahm, David John O'neill, Eddine Saiah, Sridhar Narayan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
The mechanistic target of rapamycin complex 1 (mTORC1) has been linked to several important chronic medical conditions many of which are associated with advancing age. A variety of inputs including the amino acid leucine are required for full mTORC1
Publikováno v:
Polymers, Vol 16, Iss 15, p 2186 (2024)
A comprehensive modeling framework for the thermoforming of polymer matrix woven laminate composite was developed. Two numerical indicators, the slip path length and traction magnitude, have been identified to be positively correlated to matrix smear
Externí odkaz:
https://doaj.org/article/2c61ea0616394de3b91d4e524b5c1ef0
Autor:
Lauren A. Berstler, Sarah J. Mahoney, George P. Vlasuk, Sridhar Narayan, Eddine Saiah, Seong A. Kang, Lisa Molz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
The small G-protein Rheb activates the mechanistic target of rapamycin complex 1 (mTORC1) in response to growth factor signals. mTORC1 is a master regulator of cellular growth and metabolism; aberrant mTORC1 signaling is associated with fibrotic, met
Using Squeak Etoys to Infuse Information Technology (USeIT) was designed to offer expanded information technology experiences to 155 middle and high school students over a three-year period by exploiting the Squeak Etoys media authoring tool as a sim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a834c136e4628b1abed59bf93b60860b
https://doi.org/10.4018/978-1-5225-3832-5.ch043
https://doi.org/10.4018/978-1-5225-3832-5.ch043
Autor:
David C. McKinney, Natascha Bezdenejnih-Snyder, Krista Farrington, Sridhar Narayan, Anatoly M. Ruvinsky, Jian Guo, Robert E. McLaughlin, Renu Singh, Ed T. Buurman, Gregory S. Basarab
Publikováno v:
ACS Infectious Diseases. 1:222-230
Negamycin is a hydrophilic antimicrobial translation inhibitor that crosses the lipophilic inner membrane of Escherichia coli via at least two transport routes to reach its intracellular target. In a minimal salts medium, negamycin's peptidic nature
Autor:
Yongbo Hu, Hong Du, Melvin J. Yu, Yimin Jiang, Bruce A. Littlefield, Wanjun Zheng, Sridhar Narayan, Carlson Eric, Bryan M. Lewis, Huiming Zhang, Murray J. Towle, Karen TenDyke, Boris M. Seletsky, Hongsheng Cheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1630-1633
Eribulin mesylate (Halaven™), a totally synthetic analog of the marine polyether macrolide halichondrin B, has recently been approved in the United States as a treatment for breast cancer. It is also currently under regulatory review in Japan and t
Autor:
Boris M. Seletsky, Karen TenDyke, Sean Eckley, Bruce A. Littlefield, Huiming Zhang, Hong Du, Carlson Eric, Wanjun Zheng, Yimin Jiang, Sridhar Narayan, Murray J. Towle, Yongbo Hu, Edgar Schuck, Krista Condon, Vipul Kumar, Hongsheng Cheng, Bryan M. Lewis, Philip Saxton, Melvin J. Yu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1639-1643
Novel second generation analogs of eribulin mesylate, a tubulin agent recently approved for the treatment of breast cancer, are reported. Our recent efforts have focused on expanding the target indications for this class of compounds to other tumor t
Autor:
Lars Kyhn Rasmussen, Zhenyang Lin, Guochen Jia, Brant C. Boren, Li Zhang, Sridhar Narayan, Haitao Zhao, Valery V. Fokin
Publikováno v:
Journal of the American Chemical Society. 130:8923-8930
The catalytic activity of a series of ruthenium(II) complexes in azide-alkyne cycloadditions has been evaluated. The [Cp*RuCl] complexes, such as Cp*RuCl(PPh 3) 2, Cp*RuCl(COD), and Cp*RuCl(NBD), were among the most effective catalysts. In the presen