Výsledky vyhledávání - "Sridevi Dasarathy"

Akademický článek

Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer’s disease–related mouse models

Autor: Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Pahan

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)

Glial activation and inflammation coincide with neurofibrillary tangle (NFT) formation in neurons. However, the mechanism behind the interaction between tau fibrils and glia is poorly understood. Here, we found that tau preformed fibrils (PFFs) cause

Externí odkaz: https://doaj.org/article/2c308afde27e4306aefbbd9e0739ba70

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Akademický článek

Locomotor Behavior Analysis in Spinal Cord Injured Macaca radiata after Predegenerated Peripheral Nerve Grafting—A Preliminary Evidence

Autor: Anand Paramasivam, Suresh Mickymaray, Saikarthik Jayakumar, Mathew Jeraud, Periasamy Perumal, Abdullah Alassaf, Abdullah Abdulrahman Aljabr, Sridevi Dasarathy, Suresh Babu Rangasamy

Publikováno v: Veterinary Sciences, Vol 8, Iss 12, p 288 (2021)

Introduction: Primate animal models are being utilized to explore novel therapies for spinal cord injuries. This study aimed to evaluate the efficiency of the transplantation of predegenerated nerve segments in unilateral spinal cord-hemisected bonne

Externí odkaz: https://doaj.org/article/9634f016b7be4f3a9c477f74ae3b4155

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Protection of dopaminergic neurons in hemiparkinsonian monkeys by flavouring ingredient glyceryl tribenzoate

Autor: Suresh B. Rangasamy, Debashis Dutta, Susanta Mondal, Moumita Majumder, Sridevi Dasarathy, Goutam Chandra, Kalipada Pahan

Publikováno v: NeuroImmune Pharmacology and Therapeutics. 1:7-22

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and this study underlines the significance of a small molecule glyceryl tribenzoate (GTB), a FDA approved food additive, in preventing parkinsonian pathologies in MPTP-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de85547cc2ce88eb48930792a26bb1ab
https://doi.org/10.1515/nipt-2022-0005

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Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Improves Cognitive Functions in Mice after Controlled Cortical Impact Injury

Autor: Suresh B. Rangasamy, Sumita Raha, Sridevi Dasarathy, Kalipada Pahan

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 192
International Journal of Molecular Sciences, Vol 23, Iss 192, p 192 (2022)
International Journal of Molecular Sciences

Traumatic brain injury (TBI) is a major health concern, sometimes leading to long-term neurological disability, especially in children, young adults and war veterans. Although research investigators and clinicians have applied different treatment str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2f19b0279d597c83deb0d51b0dde96

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Low-Dose Maraviroc, an Antiretroviral Drug, Attenuates the Infiltration of T Cells into the Central Nervous System and Protects the Nigrostriatum in Hemiparkinsonian Monkeys

Autor: Jeffrey H. Kordower, Susanta Mondal, Suresh B. Rangasamy, Sridevi Dasarathy, Avik Roy, Kalipada Pahan

Publikováno v: The Journal of Immunology. 202:3412-3422

Parkinson's disease (PD) is the most common neurodegenerative movement disorder in humans. Despite intense investigation, no effective therapy is available to stop the progression of this disease. It is becoming clear that both innate and adaptive im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8146ff21216165d01ea2d17ee6d396c2
https://doi.org/10.4049/jimmunol.1800587

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Locomotor Behavior Analysis in Spinal Cord Injured Macaca radiata after Predegenerated Peripheral Nerve Grafting—A Preliminary Evidence

Autor: Periasamy Perumal, Saikarthik Jayakumar, Sridevi Dasarathy, Suresh B. Rangasamy, Mathew Jeraud, Abdullah Alassaf, Suresh Mickymaray, Anand Paramasivam, Abdullah Abdulrahman Aljabr

Publikováno v: Veterinary Sciences, Vol 8, Iss 288, p 288 (2021)
Veterinary Sciences; Volume 8; Issue 12; Pages: 288
Veterinary Sciences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ea2a2111547c502cb53bc857486665
https://doi.org/10.3390/vetsci8120288

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Increase in Mitochondrial Biogenesis in Neuronal Cells by RNS60, a Physically-Modified Saline, via Phosphatidylinositol 3-Kinase-Mediated Upregulation of PGC1α

Autor: Supurna Ghosh, Suresh B. Rangasamy, Kalipada Pahan, Sridevi Dasarathy, Madhuchhanda Kundu, Richard T. Watson, Goutam Chandra

Publikováno v: Journal of Neuroimmune Pharmacology

This study highlights a novel approach to upregulate mitochondrial biogenesis in neuronal cells. RNS60 is a 0.9% saline solution containing oxygenated nanobubbles that is generated by subjecting normal saline to Taylor-Couette-Poiseuille (TCP) flow u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75607b56b7e5d41dd6832a171fe4aa48
https://doi.org/10.1007/s11481-017-9771-4

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Hyper-activation of pp60 Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury

Publikováno v: Free Radical Biology and Medicine. 102:217-228

The molecular mechanisms by which the endothelial barrier becomes compromised during lipopolysaccharide (LPS) mediated acute lung injury (ALI) are still unresolved. We have previously reported that the disruption of the endothelial barrier is due, at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fca3d873713eb3cbadbb774e15c27b
https://doi.org/10.1016/j.freeradbiomed.2016.11.008

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Endothelin-1 Induces a Glycolytic Switch in Pulmonary Arterial Endothelial Cells via the Mitochondrial Translocation of Endothelial Nitric Oxide Synthase

Autor: Yunchao Su, Yali Hou, Sanjiv Kumar, Shruti Sharma, Saurabh Aggarwal, Stephen M. Black, Jeffrey R. Fineman, Christine Gross, Sung Gon Lee, Sridevi Dasarathy, Weihong Han, Xutong Sun, Qing Lu, Mary L Meadows, Olga Rafikova

Publikováno v: American journal of respiratory cell and molecular biology, vol 50, iss 6

Recent studies have indicated that, during the development of pulmonary hypertension (PH), there is a switch from oxidative phosphorylation to glycolysis in the pulmonary endothelium. However, the mechanisms underlying this phenomenon have not been e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e10fad7d6edcb7258cc7fdc2ede15e
https://doi.org/10.1165/rcmb.2013-0187oc

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Disruption of Endothelial Cell Mitochondrial Bioenergetics in Lambs with Increased Pulmonary Blood Flow

Autor: Sohrab Fratz, Stephen M. Black, Shruti Sharma, Monique Radman, Ruslan Rafikov, Saurabh Aggarwal, Sridevi Dasarathy, Tantiana Burns, Qing Lu, Christian Schreiber, Jeffrey R. Fineman, Johnny Wright, Sanjiv Kumar, Xutong Sun, Olga Rafikova

Publikováno v: Antioxidants & redox signaling, vol 18, iss 14

Aims: The mitochondrial dysfunction in our lamb model of congenital heart disease with increased pulmonary blood flow (PBF) (Shunt) is associated with disrupted carnitine metabolism. Our recent studies have also shown that asymmetric dimethylarginine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfaeeecb1ff73921d0a4b057309a5e87
https://doi.org/10.1089/ars.2012.4806

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