Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sribalasubashini, Muralimanoharan"'
Autor:
Sribalasubashini Muralimanoharan, Ross Shamby, Nicholas Stansbury, Robert Schenken, Barbara de la Pena Avalos, Samin Javanmardi, Eloise Dray, Patrick Sung, Thomas G. Boyer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Uterine fibroid (UF) driver mutations in Mediator complex subunit 12 (MED12) trigger genomic instability and tumor development through unknown mechanisms. Herein, we show that MED12 mutations trigger aberrant R-loop-induced replication stres
Externí odkaz:
https://doaj.org/article/c0125838d6f34460b746424e73028e09
Publikováno v:
Endocrinology
Using cultured human trophoblast stem cells (hTSCs), mid-gestation human trophoblasts in primary culture, and gene-targeted mice, we tested the hypothesis that the multinucleated syncytiotrophoblast (SynT) serves a critical role in pregnancy maintena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025048b9fe55d5b4be84131d54d5c5a6
https://doi.org/10.1210/endocr/bqac070
https://doi.org/10.1210/endocr/bqac070
Human Trophoblast Differentiation Is Associated With Profound Gene Regulatory and Epigenetic Changes
Publikováno v:
Endocrinology
Defective placental implantation and vascularization with accompanying hypoxia contribute to preeclampsia (PE), a leading cause of maternal and neonatal morbidity and mortality. Genetic and epigenetic mechanisms underlying differentiation of prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a7aa91ea6835d14059eb0fc7a513e7
https://doi.org/10.1210/en.2019-00144
https://doi.org/10.1210/en.2019-00144
Publikováno v:
Endocrinology. 159:2022-2033
Dysregulation of human trophoblast invasion and differentiation with placental hypoxia can result in preeclampsia, a hypertensive disorder of pregnancy. Herein, we characterized the role and regulation of miR-1246, which is markedly induced during hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb9842dacb60f7bc1d53be5cd3146fa
https://doi.org/10.1210/en.2017-03024
https://doi.org/10.1210/en.2017-03024
Publikováno v:
International Journal of Obesity. 39:1274-1281
Maternal obesity is a major problem in obstetrics, and the placenta is involved in obesity-related complications via its roles at the maternal-fetal interface. We have recently shown a causative role for micro(mi)RNA-210, a so called 'hypoxamir' regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6243e8076bfd45d6fb64fa5692041c7
https://doi.org/10.1038/ijo.2015.45
https://doi.org/10.1038/ijo.2015.45
Autor:
Cameron P. Casey, Peter W. Nathanielsz, Ernesto S. Nakayasu, Alina Maloyan, Cun Li, Thomas O. Metz, Sribalasubashini Muralimanoharan
Poor maternal nutrition causes intrauterine growth restriction (IUGR); however, its effects on fetal cardiac development are unclear. We have developed a baboon model of moderate maternal undernutrition, leading to IUGR. We hypothesized that the IUGR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1765b182ced321beacd9770b320f8264
https://europepmc.org/articles/PMC5548301/
https://europepmc.org/articles/PMC5548301/
Publikováno v:
Placenta. 34:1183-1189
Preeclampsia (PE) affects 5–8% of pregnancies and is responsible for 18% of maternal deaths in the US, and for long-term complications in mother and child. PE is an inflammatory state and may influence placental function in a sex-specific manner. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf28f4aaf51a482ceb4849c99ad2280
https://doi.org/10.1016/j.placenta.2013.09.015
https://doi.org/10.1016/j.placenta.2013.09.015
Autor:
Peter W. Nathanielsz, Alina Maloyan, Mark J. Nijland, Steven Huffman, Leslie Myatt, Laura A. Cox, Sribalasubashini Muralimanoharan
Publikováno v:
Physiological Genomics. 45:889-900
Human and animal studies show that suboptimal intrauterine environments lead to fetal programming, predisposing offspring to disease in later life. Maternal obesity has been shown to program offspring for cardiovascular disease (CVD), diabetes, and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a6ee4e6e5cd4e24d86ae007e9811da
https://doi.org/10.1152/physiolgenomics.00050.2013
https://doi.org/10.1152/physiolgenomics.00050.2013
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Dysregulation of human trophoblast invasion and differentiation can result in preeclampsia (PE), a hypertensive disorder of pregnancy with significant morbidity and mortality for mother and offspring. miRNA microarray analysis of RNA from human cytot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c313fa5c56eb751c24b01a3f6473f5d5
https://doi.org/10.1073/pnas.1607849113
https://doi.org/10.1073/pnas.1607849113
Autor:
Alina Maloyan, Xiaoli Gao, Susan T. Weintraub, Leslie Myatt, Sribalasubashini Muralimanoharan
The incidence of maternal obesity and its co-morbidities (diabetes, cardiovascular disease) continues to increase at an alarming rate, with major public health implications. In utero exposure to maternal obesity has been associated with development o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032fa2390c8d12d2665093aa920ecbdc
https://europepmc.org/articles/PMC4854539/
https://europepmc.org/articles/PMC4854539/