Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sribalaji Lakshmikanthan"'
Autor:
Chanchal Sur Chowdhury, Elizabeth Wareham, Juying Xu, Sachin Kumar, Matthew Kofron, Sribalaji Lakshmikanthan, Magdalena Chrzanowska, Marie-Dominique Filippi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionNeutrophils are critical for host immune defense; yet, aberrant neutrophil tissue infiltration triggers tissue damage. Neutrophils are heterogeneous functionally, and adopt ‘normal’ or ‘pathogenic’ effector function responses. Und
Externí odkaz:
https://doaj.org/article/c534e99458ed422c9ee9dbae3177c31c
Autor:
Ramoji Kosuru, Bandana Singh, Sribalaji Lakshmikanthan, Yoshinori Nishijima, Jeannette Vasquez-Vivar, David X. Zhang, Magdalena Chrzanowska
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/ee84f766144340ba8328ab625c967ff5
Autor:
Ramoji Kosuru, Bandana Singh, Sribalaji Lakshmikanthan, Yoshinori Nishijima, Jeannette Vasquez-Vivar, David X. Zhang, Magdalena Chrzanowska
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Small GTPase Rap1 plays a prominent role in endothelial cell (EC) homeostasis by promoting NO release. Endothelial deletion of the two highly homologous Rap1 isoforms, Rap1A and Rap1B, leads to endothelial dysfunction ex vivo and hypertension in vivo
Externí odkaz:
https://doaj.org/article/727ec66ccc314234a4f972f3a20f24c6
Autor:
Vijay Avin Balaji Ragunathrao, Mumtaz Anwar, Md Zahid Akhter, Alejandra Chavez, De Yu Mao, Viswanathan Natarajan, Sribalaji Lakshmikanthan, Magdalena Chrzanowska-Wodnicka, Arkadiusz Z. Dudek, Lena Claesson-Welsh, Jan K. Kitajewski, Kishore K. Wary, Asrar B. Malik, Dolly Mehta
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3472-3487.e4 (2019)
Summary: The vascular endothelial growth factor-A (VEGF-A)-VEGFR2 pathway drives tumor vascularization by activating proangiogenic signaling in endothelial cells (ECs). Here, we show that EC-sphingosine-1-phosphate receptor 1 (S1PR1) amplifies VEGFR2
Externí odkaz:
https://doaj.org/article/ca069aac595949f996eaf14ed636dcbc
Autor:
Ramoji Kosuru, Magdalena Chrzanowska, Yao Chen, Shikan Zheng, Robert Burns, Gang Xin, Sribalaji Lakshmikanthan, Guru Prasad Sharma, Weiguo Cui
Publikováno v:
Angiogenesis. 26:265-278
Overcoming vascular immunosuppression: lack of endothelial cell (EC) responsiveness to inflammatory stimuli in the proangiogenic environment of tumors, is essential for successful cancer immunotherapy. The mechanisms through which Vascular Endothelia
Autor:
Sribalaji Lakshmikanthan, Magdalena Chrzanowska, Mary G. Sorci-Thomas, Rodney Sparapani, Ramoji Kosuru, David X. Zhang, Jeannette Vasquez-Vivar, Bandana Singh
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Small GTPase Rap1 (Ras-association proximate 1) is a novel, positive regulator of NO release and endothelial function with a potentially key role in mechanosensing of atheroprotective, laminar flow. Our objective was to delineate the role
Autor:
Yu-Yon Kim, Young Hoon Kim, Jaehyuk Choi, Prasad Kolli, Douglas S. Greene, Francois Lebel, Sribalaji Lakshmikanthan, In Young Choi, Tae Hun Song, J. Barrett
Publikováno v:
Experimental Hematology. 92:51-61
Eflapegrastim (Rolontis) is a long-acting granulocyte colony-stimulating factor (G-CSF) with an IgG4 Fc fragment and short polyethylene glycol linker. Current G-CSF products are administered 24 hours after chemotherapy. The present study compares the
Autor:
J. Barrett, Prasad Kolli, Shanta Chawla, Sribalaji Lakshmikanthan, Francois Lebel, Douglas S. Greene
Publikováno v:
The Journal of Clinical Pharmacology. 61:204-210
Eflapegrastim (Rolontis) is a long-acting granulocyte colony-stimulating factor (G-CSF) produced by conjugating a human G-CSF analogue and a human immunoglobulin G4 Fc fragment, linked via a polyethylene glycol linker. Weight-based doses of 45 to 270
Autor:
Sribalaji Lakshmikanthan, Damaris Diaz, Prasad Kolli, Arunthi Thiagalingam, Paul M. Gonzales, Mario Sepulveda, Jessica Dalsing-Hernandez, Francois Lebel, John A. Barrett
Publikováno v:
Cancer Research. 82:2086-2086
Glioblastoma (GBM) is inherently immunosuppressed (cold). Short term localized controlled immune activation has been shown to increase cytotoxic T cell infiltrate, resulting in reduced tumor growth and prolonged survival (Barrett et al. 2018). We hav
Autor:
Arunthi Thiagalingam, Sribalaji Lakshmikanthan, Allysia J. Mak, Scott A. Shell, Sharon Leu, Rocky Washington, Lyndah Dreiling, Gajanan Bhat, Francois Lebel, John A. Barrett
Publikováno v:
Cancer Research. 82:3400-3400
Introduction: Detection of ctDNA in plasma samples permits temporal assessment of tumor mutation status during treatment. Poziotinib is an oral pan-HER TKI that has been demonstrated to be efficacious in NSCLC patients harboring HER2 exon 20 insertio