Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Sri H. Ramarathinam"'
Autor:
Stacie S. Wang, Kirti Pandey, Katherine A. Watson, Rebecca C. Abbott, Nicole A. Mifsud, Fiona M. Gracey, Sri H. Ramarathinam, Ryan S. Cross, Anthony W. Purcell, Misty R. Jenkins
Publikováno v:
Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 167-180 (2023)
Diffuse midline glioma (DMG) is a childhood brain tumor with an extremely poor prognosis. Chimeric antigen receptor (CAR) T cell therapy has recently demonstrated some success in DMG, but there may a need to target multiple tumor-specific targets to
Externí odkaz:
https://doaj.org/article/aea552a56a254441a4a3a7761c91f3b0
Autor:
Kirti Pandey, Stacie S. Wang, Nicole A. Mifsud, Pouya Faridi, Alexander J. Davenport, Andrew I. Webb, Jarrod J. Sandow, Rochelle Ayala, Michelle Monje, Ryan S. Cross, Sri H. Ramarathinam, Misty R. Jenkins, Anthony W. Purcell
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionDiffuse intrinsic pontine glioma (DIPG), recently reclassified as a subtype of diffuse midline glioma, is a highly aggressive brainstem tumor affecting children and young adults, with no cure and a median survival of only 9 months. Conven
Externí odkaz:
https://doaj.org/article/cca9faeeedb64a64829693d53680c424
Autor:
Prithvi Raj Munday, Joshua Fehring, Jerico Revote, Kirti Pandey, Mohammad Shahbazy, Katherine E. Scull, Sri H. Ramarathinam, Pouya Faridi, Nathan P. Croft, Asolina Braun, Chen Li, Anthony W. Purcell
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1678-1687 (2023)
Immunopeptidomics has made tremendous contributions to our understanding of antigen processing and presentation, by identifying and quantifying antigenic peptides presented on the cell surface by Major Histocompatibility Complex (MHC) molecules. Larg
Externí odkaz:
https://doaj.org/article/6efafc027ba14a9c8eafbdadb25b7bb0
Autor:
Emma C. Jappe, Christian Garde, Sri H. Ramarathinam, Ethan Passantino, Patricia T. Illing, Nicole A. Mifsud, Thomas Trolle, Jens V. Kringelum, Nathan P. Croft, Anthony W. Purcell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Thermostability of the peptide-MHC interaction is important for immunogenicity. Here the authors present a mass spectrometry method to measure thermostability among thousands of peptide-MHC complexes in parallel and a trained artificial neural networ
Externí odkaz:
https://doaj.org/article/5cf6ee2c88c54b69ae8a7c1723f4491d
Autor:
Man Lyang Kim, Melinda Y. Hardy, Laura E. Edgington-Mitchell, Sri H. Ramarathinam, Shan Zou Chung, Amy K. Russell, Iain Currie, Brad E. Sleebs, Anthony W. Purcell, Jason A. Tye-Din, Ian P. Wicks
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103509- (2021)
Summary: Although hydroxychloroquine (HCQ) has long been used to treat autoimmune diseases, its mechanism of action remains poorly understood. In CD4 T-cells, we found that a clinically relevant concentration of HCQ inhibited the mitochondrial antiox
Externí odkaz:
https://doaj.org/article/b4f7fa75e9d149f7bbd861a7d084ca17
Autor:
Georges Khoury, Michelle Y. Lee, Sri H. Ramarathinam, James McMahon, Anthony W. Purcell, Secondo Sonza, Sharon R. Lewin, Damian F. J. Purcell
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
HIV-1 Tat protein is essential for virus production. RNA-binding proteins that facilitate Tat production may be absent or downregulated in resting CD4+ T-cells, the main reservoir of latent HIV in people with HIV (PWH) on antiretroviral therapy (ART)
Externí odkaz:
https://doaj.org/article/7c0b9c153da347e2a64fc1579b1b9317
Autor:
Andreas Behren, Ralf B. Schittenhelm, Anthony W. Purcell, Jonathan S. Cebon, Rochelle Ayala, Chen Li, Nathan P. Croft, Terry C.C. Lim Kam Sian, Sri H. Ramarathinam, Weisan Chen, Stephen Q. Wong, Divya Duscharla, Ritchlynn Aranha, Cyril Deceneux, Simone Ostrouska, Katherine Woods, Pouya Faridi
Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101dc697972aa21525bd453c74ac4c1c
https://doi.org/10.1158/2326-6066.22542564
https://doi.org/10.1158/2326-6066.22542564
Autor:
Andreas Behren, Ralf B. Schittenhelm, Anthony W. Purcell, Jonathan S. Cebon, Rochelle Ayala, Chen Li, Nathan P. Croft, Terry C.C. Lim Kam Sian, Sri H. Ramarathinam, Weisan Chen, Stephen Q. Wong, Divya Duscharla, Ritchlynn Aranha, Cyril Deceneux, Simone Ostrouska, Katherine Woods, Pouya Faridi
Supplementary Figures S1-S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e69eec6136b37c9b1a336e5024908c3
https://doi.org/10.1158/2326-6066.22542573
https://doi.org/10.1158/2326-6066.22542573
Autor:
Andreas Behren, Ralf B. Schittenhelm, Anthony W. Purcell, Jonathan S. Cebon, Rochelle Ayala, Chen Li, Nathan P. Croft, Terry C.C. Lim Kam Sian, Sri H. Ramarathinam, Weisan Chen, Stephen Q. Wong, Divya Duscharla, Ritchlynn Aranha, Cyril Deceneux, Simone Ostrouska, Katherine Woods, Pouya Faridi
Antigen recognition by CD8+ T cells is governed by the pool of peptide antigens presented on the cell surface in the context of HLA class I complexes. Studies have shown not only a high degree of plasticity in the immunopeptidome, but also that a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7581bef57082293b06b3b1e8f96f5d26
https://doi.org/10.1158/2326-6066.c.6549978.v1
https://doi.org/10.1158/2326-6066.c.6549978.v1
Autor:
Christian Garde, Michail A. Pavlidis, Pablo Garces, Emma J. Lange, Sri H. Ramarathinam, Mateo Sokač, Kirti Pandey, Pouya Faridi, Johanne Ahrenfeldt, Shanzou Chung, Stine Friis, Daniela Kleine-Kohlbrecher, Nicolai J. Birkbak, Jens V. Kringelum, Birgitte Rønø, Anthony W. Purcell, Thomas Trolle
SUMMARYCancer immunotherapies have greatly improved the treatment of several cancers, albeit a large fraction of patients still does not benefit from such treatments. Personalized therapies are envisioned to lead to improved outcomes, yet they have l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6d907ea0484dab60693968a532d99f
https://doi.org/10.1101/2023.03.23.533908
https://doi.org/10.1101/2023.03.23.533908