Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sri Devi Narasimhan"'
Autor:
Michael J Steinbaugh, Sri Devi Narasimhan, Stacey Robida-Stubbs, Lorenza E Moronetti Mazzeo, Jonathan M Dreyfuss, John M Hourihan, Prashant Raghavan, Theresa N Operaña, Reza Esmaillie, T Keith Blackwell
Publikováno v:
eLife, Vol 4 (2015)
In Caenorhabditis elegans, ablation of germline stem cells (GSCs) extends lifespan, but also increases fat accumulation and alters lipid metabolism, raising the intriguing question of how these effects might be related. Here, we show that a lack of G
Externí odkaz:
https://doaj.org/article/8931817616d244b3a07b0f3600bc78a3
Autor:
Sri Devi Narasimhan, Kelvin Yen, Ankita Bansal, Eun-Soo Kwon, Srivatsan Padmanabhan, Heidi A Tissenbaum
Publikováno v:
PLoS Genetics, Vol 7, Iss 4, p e1001377 (2011)
The insulin/IGF-1 signaling (IIS) pathway is a conserved regulator of longevity, development, and metabolism. In Caenorhabditis elegans IIS involves activation of DAF-2 (insulin/IGF-1 receptor tyrosine kinase), AGE-1 (PI 3-kinase), and additional dow
Externí odkaz:
https://doaj.org/article/1227eebd27cb497d906131cb24f84101
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
The nematode Caenorhabditis elegans has been employed as a model organism to study human obesity due to the conservation of the pathways that regulate energy metabolism. To assay for fat storage in C. elegans, a number of fat-soluble dyes have been e
Externí odkaz:
https://doaj.org/article/231490ea6b74439aa90f562f21ab407e
Autor:
Sri Devi Narasimhan
Publikováno v:
Cell. 169:971-973
With age, the trip to -your doctor for the annual physical check-up can be a daunting one. A perfect blood and lipid profile during youth slowly caves in to the inevitable process of aging, leading to slow but steady deflections in physiological metr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9cb044347ada2ba5b287ce67533dd31
https://doi.org/10.1016/j.cell.2017.05.032
https://doi.org/10.1016/j.cell.2017.05.032
Autor:
Sri Devi Narasimhan
Publikováno v:
Cell. 167(3)
Probably the hardest human battle, one that has lasted hundreds of thousands of years, has been the one against infection. Being able to celebrate a 30th birthday was once considered a miracle but only if one survived the perilous years of childhood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27bdbf8d33fd86a6185591da8af37c59
https://pubmed.ncbi.nlm.nih.gov/27768877
https://pubmed.ncbi.nlm.nih.gov/27768877
Autor:
Jennifer Paek, Kira Glover-Cutter, Sean P. Curran, Tammy N. Nguyen, Stacey Robida-Stubbs, Sri Devi Narasimhan, T. Keith Blackwell, Jacqueline Y. Lo, Masayuki Yamamoto, Takafumi Suzuki
Publikováno v:
Cell Metabolism. 16:526-537
SummarySKN-1/Nrf plays multiple essential roles in development and cellular homeostasis. We demonstrate that SKN-1 executes a specific and appropriate transcriptional response to changes in available nutrients, leading to metabolic adaptation. We iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1524c5dd13e5c14cca3b24cbb83b75d1
https://doi.org/10.1016/j.cmet.2012.09.007
https://doi.org/10.1016/j.cmet.2012.09.007
Autor:
T. Keith Blackwell, David M. Sabatini, Stacey Robida-Stubbs, Kira Glover-Cutter, Elke Neumann-Haefelin, Sri Devi Narasimhan, Dudley W. Lamming, Masaki Mizunuma
Publikováno v:
Cell Metabolism. 15:713-724
SummaryThe TOR kinase, which is present in the functionally distinct complexes TORC1 and TORC2, is essential for growth but associated with disease and aging. Elucidation of how TOR influences life span will identify mechanisms of fundamental importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c9f25e19c732d41b95d196cff273a9
https://doi.org/10.1016/j.cmet.2012.04.007
https://doi.org/10.1016/j.cmet.2012.04.007
Publikováno v:
Nature. 466:498-502
The insulin/IGF-1 signalling (IIS) pathway has diverse roles from metabolism to longevity1–5. In Caenorhabditis elegans, the single forkhead box O (FOXO) homologue, DAF-16, functions as the major target of the IIS pathway2,3,6,7. One of two isoform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d850615a25a868b96b5368adef079c
https://doi.org/10.1038/nature09184
https://doi.org/10.1038/nature09184
Publikováno v:
Cell Cycle. 8:3878-3884
Signal transduction pathways are tightly regulated by phosphorylation-dephosphorylation cycles and yet the mammalian genome contains far more genes that encode for protein kinases than protein phosphatases. Therefore, to target specific substrates, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586903ee49a3e39fc0fb811335f2b7db
https://doi.org/10.4161/cc.8.23.10072
https://doi.org/10.4161/cc.8.23.10072