Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Sreevalli Sharma"'
Autor:
Shahul Hameed P, Harish Kotakonda, Sreevalli Sharma, Radha Nandishaiah, Nainesh Katagihallimath, Ranga Rao, Claire Sadler, Ian Slater, Michael Morton, Abhijeeth Chandrasekaran, Ed Griffen, Dhanashree Pillai, Sambasiva Reddy, Nagakumar Bharatham, Suryanarayanan Venkatesan, Venugopal Jonnalagadda, Ramesh Jayaraman, Mahesh Nanjundappa, Maitrayee Sharma, Savitha Raveendran, Sreenath Rajagopal, Harikrishna Tumma, Amy Watters, Holly Becker, Jill Lindley, Robert Flamm, Michael Huband, Dan Sahm, Meredith Hackel, Tarun Mathur, Ruwanthi Kolamunnage-Dona, Jennifer Unsworth, Laura Mcentee, Nikki Farrington, Dhanasekaran Manickam, Narayana Chandrashekara, Sivakandan Jayachandiran, Hrushikesava Reddy, Sathya Shanker, Vijay Richard, Teby Thomas, Savitha Nagaraj, Santanu Datta, Vasan Sambandamurthy, Vasanthi Ramachandran, Robert Clay, John Tomayko, Shampa Das, Balasubramanian V
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The global crisis of antimicrobial resistance (AMR) necessitates the development of broad-spectrum antibacterial drugs effective against multi-drug resistant (MDR) pathogens. BWC0977, a Novel Bacterial Topoisomerase Inhibitor (NBTI) selectiv
Externí odkaz:
https://doaj.org/article/225808750cc14951b6c238bab08ada77
Autor:
Nagakumar Bharatham, Purnendu Bhowmik, Maho Aoki, Ui Okada, Sreevalli Sharma, Eiki Yamashita, Anirudh P. Shanbhag, Sreenath Rajagopal, Teby Thomas, Maitrayee Sarma, Riya Narjari, Savitha Nagaraj, Vasanthi Ramachandran, Nainesh Katagihallimath, Santanu Datta, Satoshi Murakami
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
OqxB is an RND (Resistance-Nodulation-Division) transporter that contributes to the antibiotic resistance in Klebsiella pneumoniae. Here, the authors report structural and functional characterization of OqxB, with insights into its substrate binding
Externí odkaz:
https://doaj.org/article/3bd2302c939d44e78640f6db420f1eb3
Autor:
Shahul Hameed P, Nagakumar Bharatham, Nainesh Katagihallimath, Sreevalli Sharma, Radha Nandishaiah, Anirudh P. Shanbhag, Teby Thomas, Riya Narjari, Maitrayee Sarma, Purnendu Bhowmik, Prakruthi Amar, Rajani Ravishankar, Ramesh Jayaraman, Kubendran Muthan, Ramesh Subbiah, Vasanthi Ramachandran, V. Balasubramanian, Santanu Datta
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
Abstract The mechanism of efflux is a tour-de-force in the bacterial armoury that has thwarted the development of novel antibiotics. We report the discovery of a novel chemical series with potent antibacterial properties that was engineered to overco
Externí odkaz:
https://doaj.org/article/7ea9439734d44af0a1b4d9b9699003a2
Autor:
Purnendu Bhowmik, Savitha Nagaraj, Sreevalli Sharma, Teby Thomas, Santanu Datta, Anirudh P. Shanbhag, Eiki Yamashita, Nainesh Katagihallimath, Ui Okada, Vasanthi Ramachandran, Nagakumar Bharatham, Sreenath Rajagopal, Satoshi Murakami, Riya Narjari, Maitrayee Sarma, Maho Aoki
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
OqxB is an RND (Resistance-Nodulation-Division) efflux pump that has emerged as a factor contributing to the antibiotic resistance in Klebsiella pneumoniae. OqxB underwent horizontal gene transfer and is now seen in other Gram-negative bacterial path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c875bf0487ae9ff7c3633c90b47b3a
https://doi.org/10.1038/s41467-021-25679-0
https://doi.org/10.1038/s41467-021-25679-0
Autor:
Vijender Panduga, Manoranjan Panda, Radha Shandil, Shridhar Narayanan, Naveen Kumar, M Sreenivasaiah, Monalisa Chatterji, Pravin S. Shirude, Claire Sadler, Vasan K. Sambandamurthy, Tommasi Ruben A, Supreeth Guptha, Jyothi Mahadevaswamy, Meenakshi Mallya, Pravin Iyer, Sreevalli Sharma, Vasanthi Ramachandran, Christopher B. Cooper, Anisha Ambady, Ashwini Narayan, Manjunatha M R, Khisi Mdluli, Scott Butler
Publikováno v:
ACS Med Chem Lett
[Image: see text] We report a novel benzimidazole (BI) based DprE1 inhibitor that resulted from scaffold morphing of a 1,4-azaindole series. The clinical progression of the 1,4-azaindole series from our previous work validates the potential of explor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b71f372de8efaf8c813fc8efd7644ae
https://pubmed.ncbi.nlm.nih.gov/31620237
https://pubmed.ncbi.nlm.nih.gov/31620237
Autor:
Manoranjan Panda, Anandkumar Raichurkar, Neela Dinesh, Vinayak Hosagrahara, Naveen Kumar, K.R. Prabhakar, Suresh Rudrapatna, Gayathri Balakrishnan, Amit K. Gupta, Vasan K. Sambandamurthy, Karthikeyan Kandaswamy, Stefan Kavanagh, Ramanatha Saralaya, Lalit kumar Jena, Shridhar Narayanan, Suresh Solapure, Robert Nanduri, V. Balasubramanian, Meenakshi Mallya, Ashwini Narayan, Sowmya Bharath, Vijender Panduga, Vikas Shinde, Jitendar Reddy, Khisi Mdluili, Christopher B. Cooper, Parvinder Kaur, Shahul Hameed P, Sreevalli Sharma, Supreeth Guptha, Kakoli Mukherjee, Sudha Ravishankar, Radha Shandil, Pravin Iyer, Shankar D. Markad, Vasanthi Ramachandran, Takahiro Yano, Jyothi Bhat, Harvey Rubin, Subramanyam J. Tantry
Publikováno v:
MedChemComm. 7:1022-1032
The success of bedaquiline as an anti-tubercular agent for the treatment of multidrug-resistant tuberculosis has validated the ATP synthesis pathway and in particular ATP synthase as an attractive target. However, limitations associated with its use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9536266d79924c4362a14dae6582a0
https://doi.org/10.1039/c5md00589b
https://doi.org/10.1039/c5md00589b
Autor:
Vaishali Humnabadkar, Claire Sadler, Tanjore S. Balganesh, Prakash Vachaspati, Disha Awasthy, Manoranjan Panda, Mick D. Fellows, Parvinder Kaur, Stewart T. Cole, Florence Pojer, Vasan K. Sambandamurthy, João Neres, Sreevalli Sharma, V. Balasubramanian, Kannan Murugan, Meenakshi Mallya, Suresh Rudrapatna, Balachandra Bandodkar, Sudhir Landge, Bheemarao G. Ugarkar, Jyothi Mahadevaswamy, Kavitha Nagalapur, Amrita B. Mullick, Vasanthi Ramachandran, Anirban Ghosh, Venkita Subbulakshmi
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:7694-7710
We report the discovery of benzothiazoles, a novel anti-mycobacterial series, identified from a whole cell based screening campaign. Benzothiazoles exert their bactericidal activity against Mycobacterium tuberculosis (Mtb) through potent inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d84f5aa2e5195a52048dc8416022f28
https://doi.org/10.1016/j.bmc.2015.11.017
https://doi.org/10.1016/j.bmc.2015.11.017
Autor:
Sandesh Jatheendranath, Gayathri Balakrishnan, Sreenivasaiah Menasinakai, Sudha Ravishankar, Vasanthi Ramachandran, Sreevalli Sharma, Charles J. Eyermann, Anisha Ambady, Suresh Rudrapatna, Naina Vinay Mudugal, Disha Awasthy, Umender Sharma, Supreeth Guptha, Vasan K. Sambandamurthy, Radha Nandishaiah, Folkert Reck
Publikováno v:
Tuberculosis. 95:589-598
DNA topoisomerases perform the essential function of maintaining DNA topology in prokaryotes. DNA gyrase, an essential enzyme that introduces negative supercoils, is a clinically validated target. However, topoisomerase I (Topo I), an enzyme responsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f64cf3f22cd0b0568dbf057fdea9c4
https://doi.org/10.1016/j.tube.2015.05.004
https://doi.org/10.1016/j.tube.2015.05.004
Autor:
Swaminathan Rajagopalan, Jitendar Reddy, Vijender Panduga, K.R. Prabhakar, Naveen Kumar, Anand Anandkumar, Ragini Singh, Vasanthi Ramachandran, Swati Khandelwal, Santanu Datta, Narasimha Rao, Shridhar Narayanan, Suresh Solapure, Malancha Karmarkar, Radha Shandil, V. Balasubramanian, Ramanatha Saralaya, Robert Nanduri, Sreevalli Sharma
Publikováno v:
Antimicrobial Agents and Chemotherapy
There are currently 18 drug classes for the treatment of tuberculosis, including those in the development pipeline. An in silico simulation enabled combing the innumerably large search space to derive multidrug combinations. Through the use of ordina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb28b7cc0a4d604dcf30dd866f7475d7
http://europepmc.org/articles/PMC4538536
http://europepmc.org/articles/PMC4538536
Autor:
Santanu Datta, Teby Thomas, Ramesh Jayaraman, Maitrayee Sarma, Ramesh Subbiah, Shahul Hameed P, V. Balasubramanian, Purnendu Bhowmik, Nainesh Katagihallimath, Radha Nandishaiah, Sreevalli Sharma, Nagakumar Bharatham, Riya Narjari, Anirudh P. Shanbhag, Rajani Ravishankar, Vasanthi Ramachandran, Kubendran Muthan, Prakruthi Amar
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
The mechanism of efflux is a tour-de-force in the bacterial armoury that has thwarted the development of novel antibiotics. We report the discovery of a novel chemical series with potent antibacterial properties that was engineered to overcome efflux
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078419a6b0c75d3fc4e53e6f12fbb415
https://pubmed.ncbi.nlm.nih.gov/29740005
https://pubmed.ncbi.nlm.nih.gov/29740005