Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes.

Autor: Albert JS; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Yerges-Armstrong LM; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Horenstein RB; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Pollin TI; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Sreenivasan UT; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Chai S; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Blaner WS; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Snitker S; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., O'Connell JR; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Gong DW; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Breyer RJ 3rd; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Ryan AS; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., McLenithan JC; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Shuldiner AR; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Sztalryd C; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.)., Damcott CM; Program for Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine (J.S.A., L.M.Y.-A., R.B.H., T.I.P., U.T.S., S.C., S.S., J.R.O., D.-W.G., J.C.M., A.R.S., C.S., C.M.D.), and the Geriatrics Research and Education Clinical Center (D.-W.G., A.S.R., A.R.S., C.S.), Department of Radiology and Nuclear Medicine (R.J.B.), and the Veterans Affairs (VA) Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine (A.S.R.), Baltimore VA Medical Center - all in Baltimore; and the Department of Medicine, Columbia University, New York (W.S.B.).

Publikováno v: The New England journal of medicine [N Engl J Med] 2014 Jun 12; Vol. 370 (24), pp. 2307-2315. Date of Electronic Publication: 2014 May 21.

Lipotoxicity as a therapeutic target in obesity and diabetic cardiomyopathy.

Autor: Michinari Nakamura

Publikováno v: Journal of Pharmacy & Pharmaceutical Sciences; 2024, p1-25, 25p

A fifty percent leucine-restricted diet reduces fat mass and improves glucose regulation.

Autor: Zhou, Ziheng¹ (AUTHOR), Yin, Hanrui¹ (AUTHOR), Guo, Yajie¹ (AUTHOR), Fang, Yuanyuan¹ (AUTHOR), Yuan, Feixiang¹ (AUTHOR), Chen, Shanghai¹ (AUTHOR), Guo, Feifan^1,2 (AUTHOR) ffguo@sibs.ac.cn

Publikováno v: Nutrition & Metabolism. 3/26/2021, Vol. 18 Issue 1, p1-12. 12p.

Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice.

Autor: Xu, Mu¹ MXu@mednet.ucla.edu, Chang, Hui-Hua^1,2 huihua@g.ucla.edu, Jung, Xiaoman¹ XJung@mednet.ucla.edu, Moro, Aune¹ AMoro@mednet.ucla.edu, Chou, Caroline Ei Ne¹ eine1991@ucla.edu, King, Jonathan¹ JKing@mednet.ucla.edu, Hines, O. Joe¹ JoeHines@mednet.ucla.edu, Sinnett-Smith, James^2,3 JSinnett@mednet.ucla.edu, Rozengurt, Enrique^2,3 ERozengurt@mednet.ucla.edu, Eibl, Guido^1,2 GEibl@mednet.ucla.edu

Publikováno v: BMC Cancer. 8/7/2018, Vol. 18 Issue 1, p1-9. 9p. 1 Chart, 4 Graphs.

Lipid Storage, Lipolysis, and Lipotoxicity in Obesity.

Autor: Engin A; Faculty of Medicine, Department of General Surgery, Gazi University, Besevler, Ankara, Turkey. dr.aengin@gmail.com.; Mustafa Kemal Mah. 2137. Sok. 8/14, 06520, Cankaya, Ankara, Turkey. dr.aengin@gmail.com.

Publikováno v: Advances in experimental medicine and biology [Adv Exp Med Biol] 2024; Vol. 1460, pp. 97-129.