Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sreenivasa Raghavan, Sankavaram"'
Autor:
Sreenivasa Raghavan Sankavaram, Ramil Hakim, Ruxandra Covacu, Arvid Frostell, Susanne Neumann, Mikael Svensson, Lou Brundin
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 950-966 (2019)
Summary: Long-term survival and integration of neural progenitor cells (NPCs) transplanted following spinal cord injury (SCI) have been observed. However, questions concerning the differentiation choice, the mechanism of action, and the contribution
Externí odkaz:
https://doaj.org/article/83daca5ac362420faeb63fda717542af
Autor:
Ramil Hakim, Ruxandra Covacu, Vasilios Zachariadis, Arvid Frostell, Sreenivasa Raghavan Sankavaram, Lou Brundin, Mikael Svensson
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2019)
Abstract Background Mesenchymal stem cells (MSCs) and their cellular response to various stimuli have been characterized in great detail in culture conditions. In contrast, the cellular response of MSCs in an in vivo setting is still uncharted territ
Externí odkaz:
https://doaj.org/article/d2e2f4b9628548509d0fbf7a08bceab8
Autor:
Jinming Han, Keying Zhu, Kai Zhou, Ramil Hakim, Sreenivasa Raghavan Sankavaram, Klas Blomgren, Harald Lund, Xing-Mei Zhang, Robert A. Harris
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6824 (2020)
Multiple sclerosis (MS) is a chronic neuroinflammatory disorder of the central nervous system (CNS) that usually presents in young adults and predominantly in females. Microglia, a major resident immune cell in the CNS, are critical players in both C
Externí odkaz:
https://doaj.org/article/2df965de578342b7ba9d1a1b0bef572e
Autor:
Ramil, Hakim, Vasilios, Zachariadis, Sreenivasa Raghavan, Sankavaram, Jinming, Han, Robert A, Harris, Lou, Brundin, Martin, Enge, Mikael, Svensson
Publikováno v:
The Journal of Neuroscience
Microglia are resident myeloid cells of the CNS. Recently, single-cell RNA sequencing (scRNAseq) has enabled description of a disease-associated microglia (DAM) with a role in neurodegeneration and demyelination. In this study, we use scRNAseq to inv
Autor:
Ramil Hakim, Lou Brundin, Susanne Neumann, Sreenivasa Raghavan Sankavaram, Arvid Frostell, Ruxandra Covacu, Mikael Svensson
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 950-966 (2019)
Summary: Long-term survival and integration of neural progenitor cells (NPCs) transplanted following spinal cord injury (SCI) have been observed. However, questions concerning the differentiation choice, the mechanism of action, and the contribution
Autor:
Mikael Svensson, Arvid Frostell, Lou Brundin, Ruxandra Covacu, Vasilios Zachariadis, Sreenivasa Raghavan Sankavaram, Ramil Hakim
Publikováno v:
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2019)
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2019)
Background Mesenchymal stem cells (MSCs) and their cellular response to various stimuli have been characterized in great detail in culture conditions. In contrast, the cellular response of MSCs in an in vivo setting is still uncharted territory. In t
Autor:
Kai Zhou, Jinming Han, Harald Lund, Keying Zhu, Ramil Hakim, Sreenivasa Raghavan Sankavaram, Klas Blomgren, Robert A. Harris, Xing-Mei Zhang
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 18
International Journal of Molecular Sciences, Vol 21, Iss 6824, p 6824 (2020)
Volume 21
Issue 18
International Journal of Molecular Sciences, Vol 21, Iss 6824, p 6824 (2020)
BackgroundMultiple Sclerosis (MS) is a chronic neuroinflammatory disorder of the central nervous system (CNS) that usually presents in young adults and predominantly in females. Microglia, a major resident immune cell in the CNS, are critical players
Autor:
Cynthia Perez Estrada, Lou Brundin, Mikael Svensson, Sreenivasa Raghavan Sankavaram, Ruxandra Covacu
Publikováno v:
Stem Cells and Development. 23:2311-2327
Hydrogen peroxide (H2O2) is a reactive oxygen species that is involved in immunity and neuroinflammation. Here, we investigated whether and how pathophysiological levels of H2O2 influenced the differentiation of neural progenitor cells (NPCs). H2O2 l
Autor:
Clas B. Johansson, Sreenivasa Raghavan Sankavaram, Tomas Olsson, Lou Brundin, Mikael Svensson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 7, p e0133903 (2015)
PLoS ONE, Vol 10, Iss 7, p e0133903 (2015)
Background It is well documented that bone marrow-derived cells can fuse with a diverse range of cells, including brain cells, under normal or pathological conditions. Inflammation leads to robust fusion of bone marrow-derived cells with Purkinje cel
Autor:
Cynthia Perez Estrada, Lou Brundin, Lisa Arvidsson, Ruxandra Covacu, Mikael Svensson, Sreenivasa Raghavan Sankavaram
Publikováno v:
Journal of neuroimmunology. 288
Studies in multiple sclerosis have demonstrated that normal-appearing white matter can harbor pathological changes. Here we investigated the effects of neuroinflammation, modeled by experimental autoimmune encephalomyelitis (EAE) on neural stem/proge