Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Sreenatha Kirakodu"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract We used a nonhuman primate model of ligature-induced periodontitis to identify patterns of gingival transcriptomic after changes demarcating phases of periodontitis lesions (initiation, progression, resolution). A total of 18 adult Macaca mu
Externí odkaz:
https://doaj.org/article/48c76a8884504a86b2dcc36917ce6dcb
Comparative Analysis of Gene Expression Patterns for Oral Epithelial Cell Functions in Periodontitis
Autor:
Octavio A. Gonzalez, Sreenatha Kirakodu, Linh M. Nguyen, Luis Orraca, Michael J. Novak, Janis Gonzalez-Martinez, Jeffrey L. Ebersole
Publikováno v:
Frontiers in Oral Health, Vol 3 (2022)
The structure and function of epithelial cells are critical for the construction and maintenance of intact epithelial surfaces throughout the body. Beyond the mechanical barrier functions, epithelial cells have been identified as active participants
Externí odkaz:
https://doaj.org/article/93da86d21d604aef9de58fcb9d2920de
Publikováno v:
Frontiers in Oral Health, Vol 3 (2022)
The epithelial barrier at mucosal sites comprises an important mechanical protective feature of innate immunity, and is intimately involved in communicating signals of infection/tissue damage to inflammatory and immune cells in these local environmen
Externí odkaz:
https://doaj.org/article/737a36655254471a908885ec3f84c2d1
Publikováno v:
Frontiers in Oral Health, Vol 2 (2021)
Although data describe the presence and increase of inflammatory mediators in the local environment in periodontitis vs. health in humans, details regarding how these responses evolve in the transition from health to disease, changes during disease p
Externí odkaz:
https://doaj.org/article/9d63d8f8a13e46cb88f5f14b32ff7004
Publikováno v:
Molecular Oral Microbiology. 38:93-114
Rhesus monkeys (n = 36) exhibiting a healthy periodontium at baseline were used to induce progressing periodontitis through ligature placement around premolar/molar teeth. Bacterial samples were collected at baseline, 0.5, 1, and 3 months of disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b51efa69c43b2833ce7531e397a85a1
https://doi.org/10.1111/omi.12377
https://doi.org/10.1111/omi.12377
Publikováno v:
Immunology
Oral mucosal tissues must react with and respond to microbes comprising the oral microbiome ecology. This study examined the interaction of the microbiome with transcriptomic footprints of apoptosis, autophagy and hypoxia pathways during periodontiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4ff26d710935edbe446bcc49101195
https://doi.org/10.1111/imm.13292
https://doi.org/10.1111/imm.13292
Autor:
Vanessa Tubero Euzebio Alves, Ahmad Al-Attar, Yelena Alimova, Marshall H. Maynard, Sreenatha Kirakodu, Andrés Martinez-Porras, Gregory S. Hawk, Jeffrey L. Ebersole, Stefan Stamm, Octavio A. Gonzalez
Publikováno v:
Infect Immun
The mechanisms through which oral commensal bacteria mitigates uncontrolled inflammatory responses of the oral mucosa remain unknown. Here, we show that representative oral bacterial species normally associated with oral health [S. gordonii (Sg), V.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085579f68f9521d91948f1ccd9fe94d8
https://doi.org/10.1128/iai.00586-21
https://doi.org/10.1128/iai.00586-21
Autor:
J. Chen, Radhakrishnan Nagarajan, Jeffrey L. Ebersole, Sreenatha Kirakodu, Octavio A. Gonzalez
Publikováno v:
J Dent Res
This investigation evaluated the relationship of the oral microbiome and gingival transcriptome in health and periodontitis in nonhuman primates ( Macaca mulatta). Subgingival plaque samples and gingival biopsies were collected from healthy sites and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed20f4b82b0ee60395d40adbc576c2d
https://doi.org/10.1177/0022034520906138
https://doi.org/10.1177/0022034520906138
Autor:
Jeffrey L. Ebersole, Armando Burgos, M. J. Novak, Sreenatha Kirakodu, Janis Gonzalez-Martinez, A.J. Stormberg, Octavio A. Gonzalez, Luis Orraca
Publikováno v:
Immunobiology. 224:196-206
Host-derived pattern recognition receptors (PRRs) are necessary for effective innate immune engagement of pathogens that express microbial-associated molecular patterns (MAMP) ligands for these PRRs. This study used a nonhuman primate model to evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed95fdbd4b6b1265f5a41def2d6bf123
https://doi.org/10.1016/j.imbio.2018.11.007
https://doi.org/10.1016/j.imbio.2018.11.007
Autor:
M. J. Novak, Octavio A. Gonzalez, Sreenatha Kirakodu, Dolph Dawson, Armando Burgos, Arnold J. Stromberg, Luis Orraca, Janis Gonzalez-Martinez, Jeffrey L. Ebersole
Publikováno v:
Journal of periodontal researchREFERENCES. 56(1)
OBJECTIVE We hypothesized that autophagy-related genes will be differentially expressed in periodontitis, suggesting an impaired gingival autophagic response associated with disease. BACKGROUND Autophagy is a cellular physiologic mechanism to maintai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da7efa2c5980577335c282f370bc133
https://pubmed.ncbi.nlm.nih.gov/32776336
https://pubmed.ncbi.nlm.nih.gov/32776336