Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sreenath Shanker"'
H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.
Autor:
Klavs R Hansen, Idit Hazan, Sreenath Shanker, Stephen Watt, Janne Verhein-Hansen, Jürg Bähler, Robert A Martienssen, Janet F Partridge, Amikam Cohen, Geneviève Thon
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001268 (2011)
Nucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9 methylation (H3K9me) and hypoacetylation have been evolutionarily conserved and are found in both m
Externí odkaz:
https://doaj.org/article/a670cdb460fd4b668806fc392be4176a
Autor:
Sreenath Shanker, Godwin Job, Olivia L George, Kevin M Creamer, Alaa Shaban, Janet F Partridge
Publikováno v:
PLoS Genetics, Vol 6, Iss 10, p e1001174 (2010)
Formation of centromeric heterochromatin in fission yeast requires the combined action of chromatin modifying enzymes and small RNAs derived from centromeric transcripts. Positive feedback mechanisms that link the RNAi pathway and the Clr4/Suv39h1 hi
Externí odkaz:
https://doaj.org/article/b5dc82926482455ba31cbcc84257455b
Autor:
Yuan-chi Lin, Kevin M. Creamer, Geoffrey Neale, Janet F. Partridge, Blaine Bartholomew, Godwin Job, Sreenath Shanker
Publikováno v:
Molecular and Cellular Biology. 34:2046-2061
Mit1 is the putative chromatin remodeling subunit of the fission yeast Snf2/histone deacetylase (HDAC) repressor complex (SHREC) and is known to repress transcription at regions of heterochromatin. However, how Mit1 modifies chromatin to silence tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630a0bdbde80f75304de84fcc11ec7bc
https://doi.org/10.1128/mcb.01609-13
https://doi.org/10.1128/mcb.01609-13
Autor:
Rajesh K. Yadav, Janet F. Partridge, Brandon R Lowe, Benjamin J. Alper, Sreenath Shanker, Godwin Job
Publikováno v:
The EMBO Journal. 32:2321-2335
Heterochromatin assembly in fission yeast depends on the Clr4 histone methyltransferase, which targets H3K9. We show that the histone deacetylase Sir2 is required for Clr4 activity at telomeres, but acts redundantly with Clr3 histone deacetylase to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42fc9b256d51524f0383b01fb86afe57
https://doi.org/10.1038/emboj.2013.143
https://doi.org/10.1038/emboj.2013.143
Publikováno v:
Nature structural & molecular biology
RNA interference (RNAi) is critical for the assembly of heterochromatin at Schizosaccharomyces pombe centromeres. Central to this process is the RNA-induced initiation of transcriptional gene silencing (RITS) complex, which physically anchors small n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4a7405c574889612eacd14797f9600
https://doi.org/10.1038/nsmb.2151
https://doi.org/10.1038/nsmb.2151
Autor:
Arthur I. Skoultchi, Sigrid Eckardt, Anilkumar Bettegowda, James A. MacLean, Yuhong Fan, Miles F. Wilkinson, Byung Ju Kim, Chih-Hong Lou, Sreenath Shanker, Anjana Bhardwaj, K. John McLaughlin, Zhiying Hu, Seung Min Yang
Publikováno v:
Molecular and Cellular Biology. 31:1275-1287
Histone H1 is an abundant and essential component of chromatin whose precise role in regulating gene expression is poorly understood. Here, we report that a major target of H1-mediated regulation in embryonic stem (ES) cells is the X-linked Rhox home
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6335bbf10d33fd4d3282b46ca0021f
https://doi.org/10.1128/mcb.00734-10
https://doi.org/10.1128/mcb.00734-10
Autor:
Janet F. Partridge, Leemor Joshua-Tor, Sreenath Shanker, Canan Kuscu, Godwin Job, Thomas Schalch, Victoria J. P. Noffsinger
Publikováno v:
Molecular Cell. 34:36-46
In fission yeast, assembly of centromeric heterochromatin requires the RITS complex, which consists of Ago1, Tas3, Chp1, and siRNAs derived from centromeric repeats. Recruitment of RITS to centromeres has been proposed to depend on siRNA-dependent ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc38b13a3084a9d2b11412b35a07cf9b
https://doi.org/10.1016/j.molcel.2009.02.024
https://doi.org/10.1016/j.molcel.2009.02.024
Publikováno v:
International Journal of Andrology. 31:462-470
The discovery of the Rhox homeobox gene cluster on the X chromosome opens up new vistas in the regulation of reproductive processes in mammals. In mice, this cluster comprises more than 30 genes that are selectively expressed in reproductive tissues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d531b59f9f4cc792f7cbb8ef9ae137c
https://doi.org/10.1111/j.1365-2605.2008.00904.x
https://doi.org/10.1111/j.1365-2605.2008.00904.x
Autor:
Yvan Pfister, Sreenath Shanker, Tao Xu, José I. Baños Sanz, Godwin Job, Thomas Schalch, Janet F. Partridge, Brandon R Lowe, Christiane Brugger, Chunxu Qu
Publikováno v:
Molecular Cell
Molecular Cell, Vol. 62, No 2 (2016) pp. 207-221
Molecular Cell, Vol. 62, No 2 (2016) pp. 207-221
Nucleosome remodeling and deacetylation (NuRD) complexes are co-transcriptional regulators implicated in differentiation, development, and diseases. Methyl-CpG binding domain (MBD) proteins play an essential role in recruitment of NuRD complexes to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450df7fa5e464860d9d5ed78319f0f8d
https://pubmed.ncbi.nlm.nih.gov/27105116
https://pubmed.ncbi.nlm.nih.gov/27105116
Autor:
Jacqueline M. Ward, Manjeet K. Rao, Yuiko Matsumoto, Sreenath Shanker, Anjana Bhardwaj, Marcy E. Richardson, Anilkumar Bettegowda, Subbarayalu Panneerdoss, Miles F. Wilkinson
Genome-wide studies have revealed that genes commonly have a high density of RNA polymerase II just downstream of the transcription start site. This has raised the possibility that genes are commonly regulated by transcriptional elongation, but this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb25ce7dc765a2715e3bf1d809e6bc2
https://europepmc.org/articles/PMC4271199/
https://europepmc.org/articles/PMC4271199/
