Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Sreenath Nair"'
Autor:
Sri Devan Appasamy, John Berrisford, Romana Gaborova, Sreenath Nair, Stephen Anyango, Sergei Grudinin, Mandar Deshpande, David Armstrong, Ivanna Pidruchna, Joseph I. J. Ellaway, Grisell Díaz Leines, Deepti Gupta, Deborah Harrus, Mihaly Varadi, Sameer Velankar
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Macromolecular complexes are essential functional units in nearly all cellular processes, and their atomic-level understanding is critical for elucidating and modulating molecular mechanisms. The Protein Data Bank (PDB) serves as the global
Externí odkaz:
https://doaj.org/article/d0756c17794b4f30a37d6a65e24cb126
Autor:
Ibrahim Roshan Kunnakkattu, Preeti Choudhary, Lukas Pravda, Nurul Nadzirin, Oliver S. Smart, Qi Yuan, Stephen Anyango, Sreenath Nair, Mihaly Varadi, Sameer Velankar
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-11 (2023)
Abstract While the Protein Data Bank (PDB) contains a wealth of structural information on ligands bound to macromolecules, their analysis can be challenging due to the large amount and diversity of data. Here, we present PDBe CCDUtils, a versatile to
Externí odkaz:
https://doaj.org/article/7838307f755a49408678c077b01f6d64
Autor:
Joseph I. J. Ellaway, Stephen Anyango, Sreenath Nair, Hossam A. Zaki, Nurul Nadzirin, Harold R. Powell, Aleksandras Gutmanas, Mihaly Varadi, Sameer Velankar
Publikováno v:
Structural Dynamics, Vol 11, Iss 3, Pp 034701-034701-8 (2024)
Studying protein dynamics and conformational heterogeneity is crucial for understanding biomolecular systems and treating disease. Despite the deposition of over 215 000 macromolecular structures in the Protein Data Bank and the advent of AI-based st
Externí odkaz:
https://doaj.org/article/2f98abeaf372423c983a6288a14b7e31
Autor:
Avinash K. Persaud, Sreenath Nair, Md Fazlur Rahman, Radhika Raj, Brenna Weadick, Debasis Nayak, Craig McElroy, Muruganandan Shanmugam, Sue Knoblaugh, Xiaolin Cheng, Rajgopal Govindarajan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Mutations in ENT3, encoded by SLC29A3, result in anaemia and erythroid hypoplasia, suggesting roles in erythropoiesis. Here the authors show that ENT3 acts as a lysosomal bile acid transporter, and mutation compromises taurine conjugated bile acid tr
Externí odkaz:
https://doaj.org/article/087a41082d3d4e2c8dbfb1af03cf1a8b
Autor:
Sreenath Nair, Anne M. Strohecker, Avinash K. Persaud, Bhawana Bissa, Shanmugam Muruganandan, Craig McElroy, Rakesh Pathak, Michelle Williams, Radhika Raj, Amal Kaddoumi, Alex Sparreboom, Aaron M. Beedle, Rajgopal Govindarajan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Mutations in equilibrative nucleoside transporter 3 (ENT3), encoded by SLC29A3, cause a spectrum of human genetic disorders. Here, the authors show altered haematopoietic stem cell and mesenchymal stem cell fates in ENT3-deficient mice, due to misreg
Externí odkaz:
https://doaj.org/article/808693518ee945b095baa8826e112354
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 8877 (2022)
The number of unique transmembrane (TM) protein structures doubled in the last four years, which can be attributed to the revolution of cryo-electron microscopy. In addition, AlphaFold2 (AF2) also provided a large number of predicted structures with
Externí odkaz:
https://doaj.org/article/8fed7da3d9534cd9ba133de49768d459
Publikováno v:
Molecules, Vol 27, Iss 17, p 5448 (2022)
IWR-1-endo, a small molecule that potently inhibits the Wnt/β-catenin signaling pathway by stabilizing the AXIN2 destruction complex, can inhibit drug efflux at the blood–brain barrier. To conduct murine cerebral microdialysis research, validated,
Externí odkaz:
https://doaj.org/article/0978174873e34ab9ab6f8ef978f8098b
Autor:
Olivia Campagne, Abigail Davis, Bo Zhong, Sreenath Nair, Victoria Haberman, Yogesh T. Patel, Laura Janke, Martine F. Roussel, Clinton Stewart
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 22, Iss 1 (2019)
PURPOSE: Cyclophosphamide is widely used to treat children with medulloblastoma; however, little is known about its brain penetration. We performed cerebral microdialysis to characterize the brain penetration of cyclophosphamide (130 mg/kg, IP) and i
Externí odkaz:
https://doaj.org/article/8e8830a614c54c6a918f8222913019e8
Autor:
Julia Benzel, Gzona Bajraktari-Sylejmani, Philipp Uhl, Abigail Davis, Sreenath Nair, Stefan M. Pfister, Walter E. Haefeli, Johanna Weiss, Jürgen Burhenne, Kristian W. Pajtler, Max Sauter
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1498 (2021)
Actinomycin D is a potent cytotoxic drug against pediatric (and other) tumors that is thought to barely cross the blood–brain barrier. To evaluate its potential applicability for the treatment of patients with central nervous system (CNS) tumors, w
Externí odkaz:
https://doaj.org/article/6d2c781dcce146709e38cf0c7f15a912
Autor:
Sreenath Nair
Publikováno v:
Body, Space & Technology Journal, Vol 12 (2013)
Mudra is a domain of movement, and it is considered to be a prominent mode of communication in dance and the dramatic arts in India. Mudra, primarily, is understood as an inscriptive form that follows the linguistic parameters, expressing symbolic me
Externí odkaz:
https://doaj.org/article/3fc5505024e14f558e34cdbfdd9b7e88