Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Sreekumar Vellalath"'
Publikováno v:
Marine Drugs, Vol 16, Iss 7, p 240 (2018)
Upon acylation of the proteasome by the β-lactone inhibitor salinosporamide A (SalA), tetrahydrofuran formation occurs by intramolecular alkylation of the incipient alkoxide onto the choroethyl sidechain and irreversibly blocks the active site. Our
Externí odkaz:
https://doaj.org/article/4fd13028966f40be960c45ec0107ffb4
Publikováno v:
RSC Advances. 13:3468-3473
Zinc-mediated carboxylation of allylic halides under flow conditions delivered β,γ-unsaturated carboxylic acids and subsequent bromolactonization provides a streamlined process for the synthesis of γ-bromo-β-lactones.
Autor:
Katherine D. Bauman, Vikram V. Shende, Percival Yang-Ting Chen, Daniela B. B. Trivella, Tobias A. M. Gulder, Sreekumar Vellalath, Daniel Romo, Bradley S. Moore
Publikováno v:
Nature chemical biology, vol 18, iss 5
The marine microbial natural product salinosporamide A (marizomib) is a potent proteasome inhibitor currently in clinical trials for the treatment of brain cancer. Salinosporamide A is characterized by a complex and densely functionalized γ-lactam-
Autor:
Katherine D, Bauman, Vikram V, Shende, Percival Yang-Ting, Chen, Daniela B B, Trivella, Tobias A M, Gulder, Sreekumar, Vellalath, Daniel, Romo, Bradley S, Moore
Publikováno v:
Nature chemical biology. 18(5)
The marine microbial natural product salinosporamide A (marizomib) is a potent proteasome inhibitor currently in clinical trials for the treatment of brain cancer. Salinosporamide A is characterized by a complex and densely functionalized γ-lactam-
Publikováno v:
Organic letters. 23(17)
An enantioselective three-component reaction was developed for the synthesis of tetrahydropyridazinones employing chiral α,β-unsaturated acylammonium salts, malonates, and azodicarboxylates. An initial α-amination of a malonate with an azodicarbox
Publikováno v:
Tetrahedron. 75:3348-3354
β-Lactones, β-lactams and epoxides are privileged structural motifs found in both therapeutics and natural products. Herein we report several strategies for annulation of these motifs onto natural products that are not known to covalently modify th
Publikováno v:
Angewandte Chemie. 130:6637-6641
Medium-sized lactams are important structural motifs found in a variety of bioactive compounds and natural products but are challenging to prepare, especially in optically active form. A Michael addition/proton transfer/lactamization organocascade pr
Autor:
Daniel Romo, Sreekumar Vellalath
Publikováno v:
Israel Journal of Chemistry. 57:335-339
A direct synthesis of the title compounds involving a stepwise Zn-mediated carboxylation of allylic bromides with CO2 delivering β, γ-unsaturated carboxylic acids and a subsequent bromolactonization is reported. The described method demonstrates th
Autor:
Sreekumar Vellalath, Daniel Romo
Publikováno v:
Angewandte Chemie International Edition. 55:13934-13943
Although acylammonium salts are well-studied, chiral α,β-unsaturated acylammonium salts have received much less attention. While these intermediates are convenient synthons, which are readily available from several commodity unsaturated acids and a
Autor:
Alexei P. Moskovets, Denis Chusov, Ekaterina A. Kuchuk, Karim M. Muratov, Sreekumar Vellalath, Oleg I. Afanasyev, Gleb L. Denisov
Publikováno v:
Organicbiomolecular chemistry. 16(41)
An efficient and highly productive rhodium-catalyzed method for the synthesis of nitriles employing aldehydes or ketones, methyl cyanoacetate, water and carbon monoxide as starting materials has been developed. Simple rhodium chloride without any lig