Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sreekanth R. Rouduri"'
Autor:
Daniel Baird, John H. Brumell, Kirsty Hooper, Leon Murphy, Jonathan M. Goodwin, Jeff Saunders, Sreekanth R. Rouduri, Sravya Kommineni, Archana Jha, Aylwin Ng, Oliver Florey, Menghao Wei, Taoyingnan Li, Mark R. Chance, Ward G. Walkup, Timothy Lehmberg, Sagar R. Budhe, Qing Tang, Jorge Garcia-Fortanet, Yaya Fan, Asmita Agrawal, Katherine Fletcher, Brent A. Appleton, Andrea Ballabio, Chieko Kishi-Itakura, Janna Kiselar
Publikováno v:
Science Advances. 7
Adaptive changes in lysosomal capacity are driven by the transcription factors TFEB and TFE3 in response to increased autophagic flux and endolysosomal stress, yet the molecular details of their activation are unclear. LC3 and GABARAP members of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b681f41d389eb5ca197aa8dd032ad11
https://doi.org/10.1126/sciadv.abj2485
https://doi.org/10.1126/sciadv.abj2485
Autor:
Madhu bala, Partha P. Mukhopadhyay, Kasim A. Mookhtiar, Bheemashankar Kulkarni, Nadim S. Shaikh, Amol A. Raje, Dhananjay N. Umrani, Debnath Bhuniya, Prasad Sherkar, Yogesh Munot, Sachin Joshi, Satyanarayan Reddy, Vishwottam Kandikere, Mahendra Lohote, Jitesh P. Iyer, Vijay Jamdar, Rajkanth Petla, Ranganayaki Nagaraj, Ravindra Gavhane, Ashwinkumar V. Meru, Sreekanth R. Rouduri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2208-2217
Targeting nuclear receptor RORγ is recognized to be beneficial in multiple autoimmune disorders. We disclosed new indole analogues as potent RORγ inverse agonists. RO-2 as one of the potent and orally bioavailable compounds was evaluated in various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a67352535118055ef6001475eb59fc
https://doi.org/10.1016/j.bmcl.2019.06.044
https://doi.org/10.1016/j.bmcl.2019.06.044
Autor:
Sagar R. Budhe, Qing Tang, Timothy Lehmberg, Andrea Ballabio, Katherine Fletcher, Menghao Wei, Asmita Agrawal, Daniel Baird, Sreekanth R. Rouduri, Ward G. Walkup, Oliver Florey, Archana Jha, John H. Brumell, Jorge Garcia-Fortanet, Leon Murphy, Sravya Kommineni, Kirsty Hooper, Jonathan M. Goodwin, Chieko Kishi-Itakura, Brent A. Appleton, Yaya Fan, Aylwin Ng, Janna Kiselar, Jeffrey J. Saunders, Mark R. Chance, Taoyingnan Li
Adaptive changes in lysosomal capacity are driven by the transcription factors TFEB and TFE3 in response to increased autophagic flux and endolysosomal stress, yet the molecular details of their activation are unclear. LC3 and GABARAP members of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::539ee4ceb1fc409289003ea1203b8149
https://doi.org/10.1101/2021.02.22.432209
https://doi.org/10.1101/2021.02.22.432209
Autor:
Azfar Quraishi, Abhay Kulkarni, Vidya Ramdas, Sreekanth R. Rouduri, Sujay Basu, Yogesh Waman, Vaibhav Jain, Anil Panmand, Vandna Prasad, Arnab Goswami, Sachin Thorat, Meena Patel, Anita Chugh, Santosh Kumar, B. Srinivasa Reddy, Syed Mustafa, Sandhya Chaturvedi, Kasim A. Mookhtiar, Siddhartha De, Ena Ray Banerjee, Suraj Menon, Minakshi Naykodi, Shalini Paliwal, Venkata P. Palle, Vikas Karande, Indraneel Ghosh, Dinesh A. Barawkar
Publikováno v:
European Journal of Medicinal Chemistry. 134:218-229
Adenosine induces bronchial hyperresponsiveness and inflammation in asthmatics through activation of A2B adenosine receptor (A2BAdoR). Selective antagonists have been shown to attenuate airway reactivity and improve inflammatory conditions in pre-cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5c77591350a111c2a6947f52eca0e5e
https://doi.org/10.1016/j.ejmech.2017.04.014
https://doi.org/10.1016/j.ejmech.2017.04.014
Autor:
Salunkhe Videsh, Madhu bala, Avinash Dhanave, Tanaji Mengawade, Vamsi Madgula, Mahesh Thakkar, Keshav Naik, Bheemashankar Kulkarni, Rahul D. Kaduskar, Dhananjay N. Umrani, Santosh Kurhade, Sachin Joshi, Amit Bhalerao, Sreekanth R. Rouduri, Vishal V Pathade, Rajkanth Petla, Swagatam Ray, Narayanan Hariharan, Kasim A. Mookhtiar, Satheesh Veerappa Avaragolla, Debnath Bhuniya, Jagadeesh Mavinahalli, Ashwini Tambe, Vaibhav Jain, Siddhartha De, Amol A. Raje, Ahmed Nadeem
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1867-1873
In a pursuit to identify reversible and selective BTK inhibitors, two series based on 7H-pyrrolo[2,3-d]pyrimidine and 1H-pyrrolo[2,3-b]pyridine as the hinge binding core, have been identified. Structure activity relationship (SAR) exploration led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59344b4bbaa9f604c182b2a0a030bcea
https://doi.org/10.1016/j.bmcl.2017.02.026
https://doi.org/10.1016/j.bmcl.2017.02.026
Autor:
Venkata P. Palle, Dinesh A. Barawkar, Vandna Prasad, Santosh Kumar, Sachin Thorat, Sreekanth R. Rouduri, Sushant Dusange, Yogesh Waman, Arnab Goswami, Anita Chugh, B. Srinivasa Reddy, Kasim A. Mookhtiar, Anil Panmand, Gaurav Bedse, Rajesh Bonagiri, Azfar Quraishi, Vikas Karande, Vidya Ramdas, Meena Patel, Indraneel Ghosh, Rhishikesh Thakre, Sujay Basu, Shalini Paliwal, Dilip Jadhav, Sandhya Chaturvedi, Partha P. Mukhopadhyay, Abhay Kulkarni, Jayasagar Gundu, Suraj Menon
Publikováno v:
European Journal of Medicinal Chemistry. 127:986-996
A2BAdoR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been implicated in lung inflammatory disorders like COPD and asthma. Several potent and selective A2BAd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ed32bbc23dd3e7768f4a309c4f2bc4e
https://doi.org/10.1016/j.ejmech.2016.11.007
https://doi.org/10.1016/j.ejmech.2016.11.007
Autor:
Azfar Quraishi, Anita Chug, Suraj Menon, Vishal Unadkat, Sujay Basu, Madhav S. Seervi, Vandna Prasad, Sumit Chaudhary, Yogesh D. Shejul, Ganesh Bhat, Sachin Thorat, Ravi K. Bhamidipati, Shariq S. Ansari, Ashwinkumar V. Meru, Rhishikesh Thakare, Kasim A. Mookhtiar, Yogesh Salve, Venkata P. Palle, Minakshi Naykodi, Siddhartha De, Vaibhav Jain, Harish Patil, Indraneel Ghosh, Dinesh A. Barawkar, Meena Patel, Sreekanth R. Rouduri
Publikováno v:
Journal of Medicinal Chemistry. 60:681-694
Our initial structure–activity relationship studies on 7-methoxy-4-morpholino-benzothiazole derivatives featured by aryloxy-2-methylpropanamide moieties at the 2-position led to identification of compound 25 as a potent and selective A2A adenosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04044ccde58cf238c9369505eaf87036
https://doi.org/10.1021/acs.jmedchem.6b01584
https://doi.org/10.1021/acs.jmedchem.6b01584
Autor:
Sujay, Basu, Dinesh A, Barawkar, Vidya, Ramdas, Minakshi, Naykodi, Yogesh D, Shejul, Meena, Patel, Sachin, Thorat, Anil, Panmand, K, Kashinath, Rajesh, Bonagiri, Vandna, Prasad, Ganesh, Bhat, Azfar, Quraishi, Sumit, Chaudhary, Amol, Magdum, Ashwinkumar V, Meru, Indraneel, Ghosh, Ravi K, Bhamidipati, Amol A, Raje, Vamsi L M, Madgula, Siddhartha, De, Sreekanth R, Rouduri, Venkata P, Palle, Anita, Chugh, Narayanan, Hariharan, Kasim A, Mookhtiar
Publikováno v:
ACS medicinal chemistry letters. 8(8)
Adenosine A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54aaa72e45a440806a9999ba7b800c85
https://pubmed.ncbi.nlm.nih.gov/28835798
https://pubmed.ncbi.nlm.nih.gov/28835798
Autor:
Sujay, Basu, Dinesh A, Barawkar, Sachin, Thorat, Yogesh D, Shejul, Meena, Patel, Minakshi, Naykodi, Vaibhav, Jain, Yogesh, Salve, Vandna, Prasad, Sumit, Chaudhary, Indraneel, Ghosh, Ganesh, Bhat, Azfar, Quraishi, Harish, Patil, Shariq, Ansari, Suraj, Menon, Vishal, Unadkat, Rhishikesh, Thakare, Madhav S, Seervi, Ashwinkumar V, Meru, Siddhartha, De, Ravi K, Bhamidipati, Sreekanth R, Rouduri, Venkata P, Palle, Anita, Chug, Kasim A, Mookhtiar
Publikováno v:
Journal of medicinal chemistry. 60(2)
Our initial structure-activity relationship studies on 7-methoxy-4-morpholino-benzothiazole derivatives featured by aryloxy-2-methylpropanamide moieties at the 2-position led to identification of compound 25 as a potent and selective A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6669e08bb0eb3701d249b4c3c0ab153e
https://pubmed.ncbi.nlm.nih.gov/28055204
https://pubmed.ncbi.nlm.nih.gov/28055204
Autor:
Sujay, Basu, Dinesh A, Barawkar, Vidya, Ramdas, Meena, Patel, Yogesh, Waman, Anil, Panmand, Santosh, Kumar, Sachin, Thorat, Minakshi, Naykodi, Arnab, Goswami, B Srinivasa, Reddy, Vandna, Prasad, Sandhya, Chaturvedi, Azfar, Quraishi, Suraj, Menon, Shalini, Paliwal, Abhay, Kulkarni, Vikas, Karande, Indraneel, Ghosh, Syed, Mustafa, Siddhartha, De, Vaibhav, Jain, Ena Ray, Banerjee, Sreekanth R, Rouduri, Venkata P, Palle, Anita, Chugh, Kasim A, Mookhtiar
Publikováno v:
European journal of medicinal chemistry. 134
Adenosine induces bronchial hyperresponsiveness and inflammation in asthmatics through activation of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c08580b2becbbacc1e9ac16e1ea3b060
https://pubmed.ncbi.nlm.nih.gov/28415011
https://pubmed.ncbi.nlm.nih.gov/28415011