Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sreekanth Puttachary"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Both Fyn and tau have been associated with neuronal hyperexcitability and neurotoxicity in many tauopathies, including Alzheimer's disease (AD). Individual genetic ablation of fyn or tau appears to be protective against aberrant excitatory neuronal a
Externí odkaz:
https://doaj.org/article/17914f6155d64083aa475a2c34c9ccc7
Autor:
Shivani Choudhary, Samuel K Buxton, Sreekanth Puttachary, Saurabh Verma, Gunnar R Mair, Ciaran J McCoy, Barbara J Reaves, Adrian J Wolstenholme, Richard J Martin, Alan P Robertson
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008396 (2020)
Nematode parasites infect approximately 1.5 billion people globally and are a significant public health concern. There is an accepted need for new, more effective anthelmintic drugs. Nicotinic acetylcholine receptors on parasite nerve and somatic mus
Externí odkaz:
https://doaj.org/article/aaa14d3e9cdb433296675d4c9b44bba7
Autor:
Marson Putra, Shaunik Sharma, Meghan Gage, Grace Gasser, Andy Hinojo-Perez, Ashley Olson, Adriana Gregory-Flores, Sreekanth Puttachary, Chong Wang, Vellareddy Anantharam, Thimmasettappa Thippeswamy
Publikováno v:
Neurobiology of Disease, Vol 133, Iss , Pp - (2020)
Chemical nerve agents (CNA) are increasingly becoming a threat to both civilians and military personnel. CNA-induced acute effects on the nervous system have been known for some time and the long-term consequences are beginning to emerge. In this stu
Externí odkaz:
https://doaj.org/article/ec8378c734124560a9373eeab90c8b8f
Autor:
Shaunik Sharma, Steven Carlson, Sreekanth Puttachary, Souvarish Sarkar, Lucas Showman, Marson Putra, Anumantha G. Kanthasamy, Thimmasettappa Thippeswamy
Publikováno v:
Neurobiology of Disease, Vol 110, Iss , Pp 102-121 (2018)
Status epilepticus (SE) induces neuroinflammation and epileptogenesis, but the mechanisms are not yet fully delineated. The Fyn, a non-receptor Src family tyrosine kinase (SFK), and its immediate downstream target, PKCδ are emerging as potential med
Externí odkaz:
https://doaj.org/article/64a5d7332d2b4d7f80a283ceb395d464
Autor:
Sreekanth Puttachary, Shaunik Sharma, Saurabh Verma, Yang Yang, Marson Putra, Achala Thippeswamy, Diou Luo, Thimmasettappa Thippeswamy
Publikováno v:
Neurobiology of Disease, Vol 93, Iss , Pp 184-200 (2016)
Status epilepticus (SE) initiates epileptogenesis to transform normal brain to epileptic state which is characterized by spontaneous recurrent seizures (SRS). Prior to SRS, progressive changes occur in the brain soon after SE, for example, loss of bl
Externí odkaz:
https://doaj.org/article/9aef96e86657404e8360478b3f788ea9
Autor:
Shaunik Sharma, Sreekanth Puttachary, Achala Thippeswamy, Anumantha G. Kanthasamy, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Various etiological factors, such as head injury, chemical intoxication, tumors, and gene mutation, can induce epileptogenesis. In animal models, status epilepticus (SE) triggers epileptogenesis. In humans, convulsive SE for >30 min can be a life-thr
Externí odkaz:
https://doaj.org/article/cfc16699527d4b5a848fa202efb25c17
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003495 (2015)
The cholinergic class of anthelmintic drugs is used for the control of parasitic nematodes. One of this class of drugs, tribendimidine (a symmetrical diamidine derivative, of amidantel), was developed in China for use in humans in the mid-1980s. It h
Externí odkaz:
https://doaj.org/article/c8388613a71b455b8f3217e10f8bb7c6
Autor:
Sreekanth Puttachary, Shaunik Sharma, Karen Tse, Edward Beamer, Abby Sexton, Joseph Crutison, Thimmasettappa Thippeswamy
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131705 (2015)
The C57BL/6J mouse as a model of seizure/epilepsy is challenging due to high mortality and huge variability in response to kainate. We have recently demonstrated that repeated administration of a low dose of kainate by intraperitoneal route can induc
Externí odkaz:
https://doaj.org/article/57990348f00445e1b835e0afebb39ebd
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96622 (2014)
A refined kainate (KA) C57BL/6J mouse model of status epilepticus (SE) using a repeated low dose (RLD) of KA (5 mg/kg, intraperitoneal; at 30 min intervals) was compared with the established single high dose (SHD) of KA (20 mg/kg, intraperitoneal) mo
Externí odkaz:
https://doaj.org/article/5bc93a1e2d3b455dad32b0837be33cec
Autor:
Anumantha G. Kanthasamy, Chandrashekhar Charavaryamath, Sanjana Mahadev Bhat, Nyzil Massey, Sreekanth Puttachary
Publikováno v:
Toxicol Sci
Occupational exposure to contaminants in agriculture and other industries is known to cause significant respiratory ailments. The effect of organic dust on lung inflammation and tissue remodeling has been actively investigated over many years but the