Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sreekanth Kokkonda"'
Autor:
Thomas A. Russo, Timothy C. Umland, Xiaoyi Deng, Farah El Mazouni, Sreekanth Kokkonda, Ruth Olson, Ulrike Carlino-MacDonald, Janet Beanan, Cassandra L. Alvarado, Diana R. Tomchick, Alan Hutson, Hong Chen, Bruce Posner, Pradipsinh K. Rathod, Susan A. Charman, Margaret A. Phillips
Publikováno v:
Proceedings of the National Academy of Sciences. 119
New antimicrobials are needed for the treatment of extensively drug-resistant Acinetobacter baumannii . The de novo pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated drug target for malaria and human autoimmune diseas
Autor:
Pradipsinh K. Rathod, Margaret A. Phillips, Michael J. Palmer, Sreekanth Kokkonda, Farah El Mazouni, John H. White, David Waterson, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Maria Santos Martinez-Martinez, Helena Barker, Leticia Huertas-Valentin, Jenna McLaren, Santiago Ferrer, Jeremy N. Burrows, Shatrughan P Shahi, Karen L. White, Maria Jose Lafuente-Monasterio, Dave Matthews, Gong Chen, Francis C. K. Chiu, David M. Shackleford, Elly Crighton, Kasiram Katneni, Xiaoyi Deng, Sergio Wittlin, Diana R. Tomchick, Susan A. Charman, Rajesh Chittimalla
Publikováno v:
J Med Chem
Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target
Autor:
Devaraja G. Mudeppa, SooNee Tan, Rapatbhorn Patrapuvich, John H. White, Pradipsinh K. Rathod, Sreekanth Kokkonda
Publikováno v:
Antimicrobial Agents and Chemotherapy. 65
Malaria parasites have three genomes: a nuclear genome, a mitochondrial genome, and an apicoplast genome. Since the apicoplast is a plastid organelle of prokaryotic origin and has no counterpart in the human host, it can be a source of novel targets
Autor:
Kamal, Ahmed, Sreekanth, Kokkonda, Kumar, P. Praveen, Shankaraiah, Nagula, Balakishan, G., Ramaiah, M. Janaki, Pushpavalli, S.N.C.V.L., Ray, Paramita, Bhadra, Manika Pal
Publikováno v:
In European Journal of Medicinal Chemistry 2010 45(6):2173-2181
Autor:
Margaret A. Phillips, David M. Shackleford, Jayan T. Joseph, Susan A. Charman, Jeremy N. Burrows, Karen L. White, John H. White, Adolfo García-Pérez, Francisco-Javier Gamo, Jorge Fernández, Krishne Manjalanagara, Paul Rowland, Michael J. Palmer, Sreekanth Kokkonda, Farah El Mazouni, Pradipsinh K. Rathod, David Waterson, Maria Jose Lafuente-Monasterio
Publikováno v:
'ACS Omega ', vol: 3, pages: 9227-9240 (2018)
Malaria kills nearly 0.5 million people yearly and impacts the lives of those living in over 90 countries where it is endemic. The current treatment programs are threatened by increasing drug resistance. Dihydroorotate dehydrogenase (DHODH) is now cl
Autor:
Yongyut Pewkliang, Sreekanth Kokkonda, Suparerk Borwornpinyo, Jetsumon Sattabongkot, Araya Jivapetthai, Pradipsinh K. Rathod, Rapatbhorn Patrapuvich, Paviga Limudompon, Phongthon Kanjanasirirat, Wanlapa Roobsoong, Osamu Kaneko, Suradej Hongeng
Background Plasmodium vivax is the most prevalent species of human malaria parasites, affecting nearly half of the world’s population. Eradication of malaria is difficult because of the ability of hypnozoite, the dormant liver-stage form of Plasmod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecc95d9a823220c7f706c5f97ff05bdf
https://doi.org/10.21203/rs.2.17895/v1
https://doi.org/10.21203/rs.2.17895/v1
Autor:
Krishne Manjalanagara, Margaret A. Phillips, Xiaoyi Deng, Michael Campbell, Karen L. White, Ric N. Price, Kennan C. Marsh, Jeremy N. Burrows, John H. White, Werner Kaminsky, Anne Marie Zeeman, Sreekanth Kokkonda, Susan A. Charman, Diana R. Tomchick, Santiago Ferrer Bazaga, Clemens H. M. Kocken, Grennady Wirjanata, Francis C. K. Chiu, María Santos Martínez, David M. Shackleford, María Belén Jiménez-Díaz, Kigbafori D. Silué, Thomas Rueckle, Jutta Marfurt, Kakali Rani Rudra, Benjamin Blasco, Iñigo Angulo-Barturen, Rintis Noviyanti, Pradipsinh K. Rathod, Maria J. Lafuente-Monasterio, Michael J. Palmer, Dave Matthews, Emilie Rossignol, David Waterson, Didier Leroy, Farah El Mazouni
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
The emergence of drug-resistant malaria parasites continues to hamper efforts to control this lethal disease. Dihydroorotate dehydrogenase has recently been validated as a new target for the treatment of malaria, and a selective inhibitor (DSM265) of
Autor:
Jeremy N. Burrows, María Belén Jiménez-Díaz, John H. White, Maria L. Marco, Maria Santos Martinez-Martinez, Sreekanth Kokkonda, Margaret A. Phillips, David Waterson, Laura Fernández de las Heras, Xiaoyi Deng, Iñigo Angulo-Barturen, Farah El Mazouni, Kakali Rani Rudra, Julia Morizzi, Santiago Ferrer Bazaga, Gong Chen, Didier Leroy, Pradipsinh K. Rathod, Diana R. Tomchick, Karen L. White, Eileen Ryan, Jose M. Coteron, Dave Matthews, Werner Kaminsky, Krishne Manjalanagara, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Malaria persists as one of the most devastating global infectious diseases. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) has been identified as a new malaria drug target, and a triazolopyrimidine-based DHODH inhibitor 1 (DS
Autor:
Sreekanth, Kokkonda, Farah, El Mazouni, Karen L, White, John, White, David M, Shackleford, Maria Jose, Lafuente-Monasterio, Paul, Rowland, Krishne, Manjalanagara, Jayan T, Joseph, Adolfo, Garcia-Pérez, Jorge, Fernandez, Francisco Javier, Gamo, David, Waterson, Jeremy N, Burrows, Michael J, Palmer, Susan A, Charman, Pradipsinh K, Rathod, Margaret A, Phillips
Publikováno v:
ACS Omega
Malaria kills nearly 0.5 million people yearly and impacts the lives of those living in over 90 countries where it is endemic. The current treatment programs are threatened by increasing drug resistance. Dihydroorotate dehydrogenase (DHODH) is now cl
Publikováno v:
Journal of Biological Chemistry. 290:20313-20324
Historically, type II topoisomerases have yielded clinically useful drugs for the treatment of bacterial infections and cancer, but the corresponding enzymes from malaria parasites remain understudied. This is due to the general challenges of produci