Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sreekanth C Narayanapillai"'
Autor:
Yi Wang, Shainnel O Eans, Heather M Stacy, Sreekanth C Narayanapillai, Abhisheak Sharma, Naomi Fujioka, Linda Haddad, Jay McLaughlin, Bonnie A Avery, Chengguo Xing
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197940 (2018)
Kava is regaining its popularity with detailed characterizations warranted. We developed an ultraperformance liquid chromatography high-resolution tandem mass spectrometry (UPLC-MS/MS) method for major kavalactones (kavain, dihydrokavain, methysticin
Externí odkaz:
https://doaj.org/article/3fffdd750ee94a64b3324ae465170f31
Autor:
Chengguo Xing, Junxuan Lu, Stephen S. Hecht, M. Gerard O'Sullivan, Ahmad Ali Shaik, Pramod Upadhyaya, Bo Zhou, Silvia Balbo, Sreekanth C. Narayanapillai, Pablo Leitzman
We previously reported the chemopreventive potential of kava against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- and benzo(a)pyrene (BaP)–induced lung tumorigenesis in A/J mice during the initiation and postinitiation stages. In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b056233f3016accbf7199048e18182d
https://doi.org/10.1158/1940-6207.c.6544826
https://doi.org/10.1158/1940-6207.c.6544826
Autor:
Chengguo Xing, Naomi Fujioka, Dorothy K. Hatsukami, Stephen S. Hecht, Junxuan Lu, Ramzi G. Salloum, Rick Kingston, Qi Hu, Pramod Upadhyaya, Lori G. Strayer, Katelyn M. Tessier, Sreekanth C. Narayanapillai, Yi Wang
Tobacco smoking is the primary risk factor for lung cancer, driven by the addictive nature of nicotine and the indisputable carcinogenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) as well as other compounds. The integration of lung ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9da43619284892ddcba2df312eed6a91
https://doi.org/10.1158/1940-6207.c.6547441.v1
https://doi.org/10.1158/1940-6207.c.6547441.v1
Autor:
Chengguo Xing, Junxuan Lu, Stephen S. Hecht, M. Gerard O'Sullivan, Ahmad Ali Shaik, Pramod Upadhyaya, Bo Zhou, Silvia Balbo, Sreekanth C. Narayanapillai, Pablo Leitzman
PDF file - 338K, Supplementary Figure 1. Study design for evaluating the chemopreventive efficacy of different kava treatment regimens against NNK-induced lung adenoma formation in A/J mice. Supplementary Figure 2. Representative photomicrographs H&E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e84aaaeb29f4101a16f1e3066c49e26
https://doi.org/10.1158/1940-6207.22525616.v1
https://doi.org/10.1158/1940-6207.22525616.v1
Autor:
Chengguo Xing, Naomi Fujioka, Dorothy K. Hatsukami, Stephen S. Hecht, Junxuan Lu, Ramzi G. Salloum, Rick Kingston, Qi Hu, Pramod Upadhyaya, Lori G. Strayer, Katelyn M. Tessier, Sreekanth C. Narayanapillai, Yi Wang
Supplemental Tables 1-7 and Supplemental Figures 1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e47ee08eb5b3ed277c5787b5d7e34f
https://doi.org/10.1158/1940-6207.22534279.v1
https://doi.org/10.1158/1940-6207.22534279.v1
Autor:
Pablo Leitzman, Chengguo Xing, Pedro Corral, Sreekanth C. Narayanapillai, M. Gerard O'Sullivan, Junxuan Lu, Stephen S. Hecht, Pramod Upadhyaya, Qi Hu
Publikováno v:
Chem Res Toxicol
Our early studies demonstrated an impressive chemopreventive efficacy of dihydromethysticin (DHM), unique in kava, against tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice, in which DHM wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40372fc52b97f106838b39cce283926
https://doi.org/10.1021/acs.chemrestox.0c00161
https://doi.org/10.1021/acs.chemrestox.0c00161
Autor:
Naomi Fujioka, Junxuan Lu, Chengguo Xing, Katelyn M. Tessier, Sreekanth C. Narayanapillai, Qi Hu, Ramzi G. Salloum, Dorothy K. Hatsukami, Stephen S. Hecht, Yi Wang, Pramod Upadhyaya, Lori S Strayer, Richard L. Kingston
Publikováno v:
Cancer Prev Res (Phila)
Tobacco smoking is the primary risk factor for lung cancer, driven by the addictive nature of nicotine and the indisputable carcinogenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) as well as other compounds. The integration of lung ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01063dd06d7946ed1824e75a983be3f
https://doi.org/10.1158/1940-6207.capr-19-0501
https://doi.org/10.1158/1940-6207.capr-19-0501
Publikováno v:
Toxicol Lett
4-(Methylnitrosamino)-l-(3-pyridyl)-1-butanone (NNK) and N-nitrosonornicotine (NNN), two tobacco specific nitrosamine carcinogens, can form adducts with DNA and proteins via pyridyloxobutylation upon phase I enzyme-mediated bioactivation. Such DNA mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5454ab9ee796f9d9bf48235c5841d191
https://doi.org/10.1016/j.toxlet.2019.04.020
https://doi.org/10.1016/j.toxlet.2019.04.020
Autor:
Fekadu Kassie, Manaye Ebabu Kebede, Jung Min Song, Sreekanth C. Narayanapillai, Pramod Upadhyaya, Yong Hwan Han
Publikováno v:
Carcinogenesis
Chronic obstructive pulmonary disease (COPD) is a significant risk factor for lung cancer. One potential mechanism through which COPD contributes to lung cancer development could be through generation of an immunosuppressive microenvironment that all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0373daf7ea30cd8eba7bba5f08bfeca
https://europepmc.org/articles/PMC8241221/
https://europepmc.org/articles/PMC8241221/
Autor:
Sreekanth C. Narayanapillai, Pablo Leitzman, M. Gerard O'Sullivan, Manohar Puppala, Haifeng Sun, Stephen S. Hecht, Chengguo Xing, Pramod Upadhyaya
Publikováno v:
Journal of Medicinal Chemistry. 60:7935-7940
(+)-Dihydromethysticin was recently identified as a promising lung cancer chemopreventive agent, while (+)-dihydrokavain was completely ineffective. A pilot in vivo structure–activity relationship (SAR) was explored, evaluating the efficacy of its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c5301a89c6149ed45c7d284c15de413
https://doi.org/10.1021/acs.jmedchem.7b00921
https://doi.org/10.1021/acs.jmedchem.7b00921