Výsledky vyhledávání - "Sreekanth, Sivan"

Integrated computational approach for in silico design of new purinyl pyridine derivatives as B-Raf kinase inhibitors

Autor: Vinutha Kuchana, Sreekanth Sivan, Sai Kiran Reddy Peddi, Vijjulatha Manga, Vaeshnavi Kashetti

Publikováno v: Journal of Receptors and Signal Transduction. 42:439-453

B-Raf is one among the most frequently mutating proto-oncogene which is associated with the serine/threonine Raf kinase family involved in the RAS-RAF-MEK-ERK pathway, which is the most deregulated pathway in human cancers. Mutant B-Raf V600E got an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e626ee5140b8d400000d0a800f2fda84
https://doi.org/10.1080/10799893.2021.1999472

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Integrated molecular docking, 3D QSAR and molecular dynamics simulation studies on indole derivatives for designing new Pim-1 inhibitors

Autor: Vijjulatha Manga, Saikiran Reddy Peddi, Sreekanth Sivan, Radhika Veerati, Sudhir Reddy Peddi

Publikováno v: Journal of Receptors and Signal Transduction. 40:1-14

Pim-1 is one of the isoforms of pim proteins comprising pim-1, pim-2 and pim-3. It was basically recognized as proviral integration moloney murine leukemia virus which is associated with T-cell lymphomogenesis. Pim-1 is known to play a crucial role i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108d6f422caf97e0734e4d53a7411785
https://doi.org/10.1080/10799893.2020.1713809

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Spectro Analytical, Computational and In Vitro Biological Studies of Novel Substituted Quinolone Hydrazone and it's Metal Complexes

Autor: Mohmed Jaheer, Sarala Devi Ch, Ravi Mudavath, Narsimha Nagula, Sudeepa Kunche, Sreekanth Sivan

Publikováno v: Journal of fluorescence. 28(1)

Some novel transition metal [Cu (II), Ni (II) and Co (II)] complexes of nalidixic acid hydrazone have been prepared and characterized by employing spectro-analytical techniques viz: elemental analysis, 1H-NMR, Mass, UV–Vis, IR, TGA-DTA, SEM-EDX, ES

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1139971c604c5e12346c1a326a62ba1c
https://pubmed.ncbi.nlm.nih.gov/29164479

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A novel piperazine linked β-amino alcohols bearing a benzosuberone scaffolds as anti-proliferative agents

Autor: Bala Bhaskar, Sreekanth Sivan, Jagadeesh Babu Nanubolu, Rajashaker Bantu, Nishant Jain, Vijjulatha Manga, Yasodakrishna Sajja, Lavanya Jilla, Sowmya Vanguru, Lingaiah Nagarapu

Publikováno v: Bioorganicmedicinal chemistry letters. 27(4)

A new series of 1-((9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzo[7]annulen-8-yl)methoxy)-3-(4-phenylpiperzin-1-yl) propan-2-ols (6a-k) have been designed, synthesized and their structures were established by spectroscopic data (FT-IR, 1H NMR, 13C NMR,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c16672914b61a65f417636aaf6c3e8
https://pubmed.ncbi.nlm.nih.gov/28117204

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Synthesis, Spectral Characterization, DNA/ Protein Binding, DNA Cleavage, Cytotoxicity, Antioxidative and Molecular Docking Studies of Cu(II)Complexes Containing Schiff Base-bpy/Phen Ligands

Autor: Ravula Chandrashekar, Vijjulatha Manga, B. Anupama, Airva Aruna, Madamsetty Vijay Sagar, Sreekanth Sivan

Publikováno v: Journal of fluorescence. 27(3)

Ternary Cu(II) complexes [Cu(II)(L)(bpy)Cl] 1, [Cu(II)(L)(Phen)Cl] 2 [L = 2,3–dimethyl-1-phenyl-4(2 hydroxy-5-methyl benzylideneamino)-pyrazol-5-one, bpy = 2,2′ bipyridine, phen =1,10 phenanthroline) were synthesized and characterized by elementa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25df02492b176054dff0c4d22f9aacc
https://pubmed.ncbi.nlm.nih.gov/28097460

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Design, synthesis, molecular docking and biological evaluation of new dithiocarbamates substituted benzimidazole and chalcones as possible chemotherapeutic agents

Autor: Keerthana Bacharaju, Swathi Reddy Jambula, Vijjulatha Manga, Sreekanth Sivan, Saritha JyostnaTangeda

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:3274-3277

A series of novel dithiocarbamates with benzimidazole and chalcone scaffold have been designed synthesised and evaluated for their antimitotic activity. Compounds 4c and 9d display the most promising antimitotic activity with IC 50 of 1.66 μM and 1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb35674d8be4d427fce919eae56f4083
https://doi.org/10.1016/j.bmcl.2012.03.018

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