Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sreeja Roy"'
Autor:
Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Michelle Lin, Monique L. Henriquez, Sreeja Roy, Hyungseok Seo, Xue Lei, Eric S. Wang, Savio Chow, Roberto Tinoco, Gregory A. Daniels, Kevin Yip, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112436- (2023)
Summary: PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism of action. Here, we show that PSGL-1 acts upstream of PD-1 and requires co-ligation with the T cell receptor (TCR) to atten
Externí odkaz:
https://doaj.org/article/067e0e4ee8fd4b5a973b514304627b4f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract IL-4 production is associated with low-avidity, poorly cytotoxic T cell induction that contributes to viral immune evasion and the failure of T cell-based vaccines. Yet, the precise mechanisms that regulate IL-4 signalling in T cells remain
Externí odkaz:
https://doaj.org/article/9d3a69cae7d44875ab35f73cf32c12c7
Autor:
Clare M Williams, Sreeja Roy, Wei Sun, Andrea M Furuya, Danushka K Wijesundara, Yoichi Furuya
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 3, Pp n/a-n/a (2022)
Abstract Group 2 innate lymphoid cells (ILC2) are a relatively new class of innate immune cells. Lung ILC2 are early responders that secrete type 2 cytokines in response to danger ‘alarmin’ signals such as interleukin (IL)‐33 and thymic stromal
Externí odkaz:
https://doaj.org/article/d2996f0cafee4670aa3b8594262405bc
Publikováno v:
Health Science Reports, Vol 4, Iss 3, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/ba3f5840dbed4f09a225a9e984b91072
Publikováno v:
Bio-Protocol, Vol 10, Iss 8 (2020)
Asthma is a global problem that affects millions of individuals. An increased risk of respiratory viral and bacterial infections is one of the complications of asthma. We recently reported that mice with ovalbumin-induced allergic airway disease (AAD
Externí odkaz:
https://doaj.org/article/9f299466806342fda1af9b20cd6f7260
Publikováno v:
Vaccines, Vol 9, Iss 5, p 440 (2021)
We have shown that manipulation of IL-13 and STAT6 signaling at the vaccination site can lead to different innate lymphoid cell (ILC)/dendritic cell (DC) recruitment, resulting in high avidity/poly-functional T cells and effective antibody differenti
Externí odkaz:
https://doaj.org/article/4930cf1bebb44d6daeed47063ee01caa
Publikováno v:
Vaccines, Vol 8, Iss 4, p 683 (2020)
During the previous influenza seasons, between 2010 and 2016, the live attenuated influenza vaccine (LAIV) provided variable efficacy against influenza in the U.S., causing the recommendation against the use of the LAIV. In striking contrast, pre-cli
Externí odkaz:
https://doaj.org/article/f60d06e423bb4ec8beba21c5c81737ad
Autor:
Jennifer Hope, Yijuan Zhang, Ashley Palete, Hannah Faso, Sreeja Roy, Dennis Otero, Swetha Maganti, Cosimo Commisso, Linda Bradley
Publikováno v:
Regular and Young Investigator Award Abstracts.
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2465
Recently, we have shown that fate of a vaccine is determined by the cytokine milieu in the innate immune compartment at the early stage of vaccination. Specifically, 24 h post-delivery, level of innate lymphoid cell type 2 (ILC2)-derived IL-13/IL-13R
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
This study demonstrates that 24 h following viral vector-based vaccination IL-13Rα2 functions as a master sensor on conventional dendritic cells (cDCs), abetted by high protein stability coupled with minimal mRNA expression, to rapidly regulate DC m