Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Sree Deepthi Muthukrishnan"'
Autor:
Sree Deepthi Muthukrishnan, Riki Kawaguchi, Pooja Nair, Rachna Prasad, Yue Qin, Maverick Johnson, Qing Wang, Nathan VanderVeer-Harris, Amy Pham, Alvaro G. Alvarado, Michael C. Condro, Fuying Gao, Raymond Gau, Maria G. Castro, Pedro R. Lowenstein, Arjun Deb, Jason D. Hinman, Frank Pajonk, Terry C. Burns, Steven A. Goldman, Daniel H. Geschwind, Harley I. Kornblum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Therapeutic stress induces phenotypic plasticity in glioma stem cells although the mechanisms underlying this remain poorly understood. Here, the authors show that P300 mediates the radiation-induced vascular-like conversion of glioma stem cells to p
Externí odkaz:
https://doaj.org/article/2f813af486a84bc6939ddacebcf2e7f8
Autor:
Sara Duhachek‐Muggy, Kruttika Bhat, Paul Medina, Fei Cheng, Ling He, Claudia Alli, Mohammad Saki, Sree Deepthi Muthukrishnan, Gregoire Ruffenach, Mansoureh Eghbali, Erina Vlashi, Frank Pajonk
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 1, Pp 106-119 (2020)
Abstract The objective of the study was to identify the mechanism of action for a radiation mitigator of the gastrointestinal (GI) acute radiation syndrome (ARS), identified in an unbiased high‐throughput screen. We used mice irradiated with a leth
Externí odkaz:
https://doaj.org/article/91a88a70c1ea425785506c378e541c3e
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 1 (2018)
The final nephron number in an adult kidney is regulated by nephron progenitor cell availability and collecting duct branching in the fetal period. Fetal environmental perturbations that cause reductions in cell numbers in these two compartments resu
Externí odkaz:
https://doaj.org/article/07ac48dbde164dfcb5fff3491ef0819e
Autor:
Alvaro G. Alvarado, Kaleab Tessema, Sree Deepthi Muthukrishnan, Mackenzie Sober, Riki Kawaguchi, Dan R. Laks, Aparna Bhaduri, Vivek Swarup, David A. Nathanson, Daniel H. Geschwind, Steven A. Goldman, Harley I. Kornblum
Publikováno v:
Cancer Res Commun
Analysis of tumor gene expression is an important approach for the classification and identification of therapeutic vulnerabilities. However, targeting glioblastoma (GBM) based on molecular subtyping has not yet translated into successful therapies.
Autor:
Harley I. Kornblum, Steven A. Goldman, Daniel H. Geschwind, David A. Nathanson, Vivek Swarup, Aparna Bhaduri, Dan R. Laks, Riki Kawaguchi, Mackenzie Sober, Sree Deepthi Muthukrishnan, Kaleab Tessema, Alvaro G. Alvarado
TCGA gene ontology analysis of clusters shows differentially enriched terms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82852d29e558451cd92ef86cad14725
https://doi.org/10.1158/2767-9764.22545783
https://doi.org/10.1158/2767-9764.22545783
Autor:
Harley I. Kornblum, Steven A. Goldman, Daniel H. Geschwind, David A. Nathanson, Vivek Swarup, Aparna Bhaduri, Dan R. Laks, Riki Kawaguchi, Mackenzie Sober, Sree Deepthi Muthukrishnan, Kaleab Tessema, Alvaro G. Alvarado
GO terms and TF enriched in modules associated with GS clusters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515916bcba43d8f605bfc9b8852192e3
https://doi.org/10.1158/2767-9764.22545768.v1
https://doi.org/10.1158/2767-9764.22545768.v1
Data from Pathway-based Approach Reveals Differential Sensitivity to E2F1 Inhibition in Glioblastoma
Autor:
Harley I. Kornblum, Steven A. Goldman, Daniel H. Geschwind, David A. Nathanson, Vivek Swarup, Aparna Bhaduri, Dan R. Laks, Riki Kawaguchi, Mackenzie Sober, Sree Deepthi Muthukrishnan, Kaleab Tessema, Alvaro G. Alvarado
Analysis of tumor gene expression is an important approach for the classification and identification of therapeutic vulnerabilities. However, targeting glioblastoma (GBM) based on molecular subtyping has not yet translated into successful therapies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0946f913f7ae9d63dd28e19b5ff0a01b
https://doi.org/10.1158/2767-9764.c.6551028
https://doi.org/10.1158/2767-9764.c.6551028
Single-nucleus expression analysis characterizes non-enhancing region of recurrent high-grade glioma
Autor:
Kunal S. Patel, Kaleab K. Tessema, Riki Kawaguchi, Alvaro G. Alvarado, Sree Deepthi Muthukrishnan, Akifumi Hagiwara, Vivek Swarup, Linda M. Liau, Anthony Wang, William Yong, Daniel H. Geschwind, Ichiro Nakano, Steven A. Goldman, Richard Everson, Benjamin M. Ellingson, Harley I. Kornblum
Non-enhancing (NE) infiltrating tumor cells beyond the contrast-enhancing (CE) bulk of tumor are potential propagators of recurrence after gross total resection of high-grade glioma. We leveraged single-nucleus RNA-sequencing to compare prospectively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abbdab6faf3297ee26b287147fe997fe
https://doi.org/10.1101/2022.10.10.511639
https://doi.org/10.1101/2022.10.10.511639
Autor:
Kirsten Ludwig, Janel E. Le Belle, Sree Deepthi Muthukrishnan, Jantzen Sperry, Michael Condro, Erina Vlashi, Frank Pajonk, Harley I. Kornblum
AimsThe goal of this study was to determine whether NADPH oxidase (NOX)-produced reactive oxygen species enhances brain tumor growth of glioblastoma (GBM) under hypoxic conditions and during radiation treatment.ResultsExogenous ROS promoted brain tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f019bf382cd9744cccc69338e9f96cee
https://doi.org/10.1101/2022.06.16.496502
https://doi.org/10.1101/2022.06.16.496502
Autor:
Fanny M. Elahi, Visesha Kakarla, Naoki Kaneko, Sandro Satta, David S Liebeskind, Jennifer An, Sree Deepthi Muthukrishnan, Tzung K. Hsiai, Jason D Hinman, Yutaro Komuro, Harley I. Kornblum, Lea Guo
Publikováno v:
Stroke, vol 52, iss 1
Background and Purpose: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with an increased rate of cerebrovascular events including ischemic stroke and intracerebral hemorrhage. The mechanisms underlying cerebral e