Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Srdjan Sarikas"'
Autor:
Nastja Sluga, Lidija Križančić Bombek, Jasmina Kerčmar, Srdjan Sarikas, Sandra Postić, Johannes Pfabe, Maša Skelin Klemen, Dean Korošak, Andraž Stožer, Marjan Slak Rupnik
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Adrenaline inhibits insulin secretion from pancreatic beta cells to allow an organism to cover immediate energy needs by unlocking internal nutrient reserves. The stimulation of α2-adrenergic receptors on the plasma membrane of beta cells reduces th
Externí odkaz:
https://doaj.org/article/9a229ca41a2e4fb1889a8a0e1a215944
Autor:
Sandra Postić, Marko Gosak, Wen-Hao Tsai, Johannes Pfabe, Srdjan Sarikas, Andraž Stožer, Dean Korošak, Shi-Bing Yang, Marjan Slak Rupnik
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Extracellular pH has the potential to affect various aspects of the pancreatic beta cell function. To explain this effect, a number of mechanisms was proposed involving both extracellular and intracellular targets and pathways. Here, we focus on reas
Externí odkaz:
https://doaj.org/article/96b4a8309fd04ed1b107131776c077d2
Autor:
Mato Lagator, Srdjan Sarikas, Magdalena Steinrueck, David Toledo-Aparicio, Jonathan P Bollback, Calin C Guet, Gašper Tkačik
Publikováno v:
eLife, Vol 11 (2022)
Predicting function from sequence is a central problem of biology. Currently, this is possible only locally in a narrow mutational neighborhood around a wildtype sequence rather than globally from any sequence. Using random mutant libraries, we devel
Externí odkaz:
https://doaj.org/article/50f68b595e8143fc96311c7d7b58db73
Publikováno v:
Cells, Vol 10, Iss 7, p 1580 (2021)
Cholinergic innervation in the pancreas controls both the release of digestive enzymes to support the intestinal digestion and absorption, as well as insulin release to promote nutrient use in the cells of the body. The effects of muscarinic receptor
Externí odkaz:
https://doaj.org/article/ab4d49a69c1843d1bd20da130709d1ac
Publikováno v:
eLife, Vol 6 (2017)
Most phenotypes are determined by molecular systems composed of specifically interacting molecules. However, unlike for individual components, little is known about the distributions of mutational effects of molecular systems as a whole. We ask how t
Externí odkaz:
https://doaj.org/article/f3152bb3aae6497dbabc9b9a5e0fa0a2
Autor:
Sandra Postić, Srdjan Sarikas, Johannes Pfabe, Viljem Pohorec, Lidija Križančić Bombek, Nastja Sluga, Maša Skelin Klemen, Jurij Dolenšek, Dean Korošak, Andraž Stožer, Carmella Evans-Molina, James D. Johnson, Marjan Slak Rupnik
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 324:E42-E55
Physiological glucose or ryanodine stimulation of β cell collectives generates a large number of [Ca2+]c events, which can be rapidly assessed with our newly developed automatic image segmentation and [Ca2+]c event identification pipeline. The event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78a069c6427a6d3af045dba9e6046bb7
https://doi.org/10.1152/ajpendo.00165.2022
https://doi.org/10.1152/ajpendo.00165.2022
Autor:
Ya-Chi Huang, Marjan Slak Rupnik, Dean Korošak, Thomas Pieber, Barbara Ehall, Srdjan Sarikas, Johannes Pfabe, Sandra Postić
The mechanisms accounting for the functional changes of α- and β-cells over the course of Type 1 Diabetes (T1D) development are largely unknown. Permitted by our established technology of high spatiotemporal resolution imaging of cytosolic Ca2+ ([C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7d460db11df727a5e38852199f42ac
https://doi.org/10.2337/figshare.23223260
https://doi.org/10.2337/figshare.23223260
Autor:
Sandra Postić, Johannes Pfabe, Srdjan Sarikas, Barbara Ehall, Thomas Pieber, Dean Korošak, Marjan Slak Rupnik, Ya-Chi Huang
Publikováno v:
Diabetes.
The mechanisms accounting for the functional changes of α- and β-cells over the course of Type 1 Diabetes (T1D) development are largely unknown. Permitted by our established technology of high spatiotemporal resolution imaging of cytosolic Ca2+ ([C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69e184caa1b40986b83f1fdd28b0b96f
https://doi.org/10.2337/db22-0952
https://doi.org/10.2337/db22-0952
Since bacteria lack a nucleus, the location of mRNA molecules is determined by the different characteristics of the encoded proteins, and the transcriptome is spatially arranged into cytosolic and membrane-associated mRNA. While translation of membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be23c14d0c278f224755a9bf0da35430
https://doi.org/10.1101/2022.12.16.520495
https://doi.org/10.1101/2022.12.16.520495
Autor:
Sandra, Postić, Srdjan, Sarikas, Johannes, Pfabe, Viljem, Pohorec, Lidija, Križančić Bombek, Nastja, Sluga, Maša, Skelin Klemen, Jurij, Dolenšek, Dean, Korošak, Andraž, Stožer, Carmella, Evans-Molina, James D, Johnson, Marjan, Slak Rupnik
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 324(1)
The release of peptide hormones is predominantly regulated by a transient increase in cytosolic Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8c67f73f410b90f42f5e93328ef501b
https://pubmed.ncbi.nlm.nih.gov/36449570
https://pubmed.ncbi.nlm.nih.gov/36449570