Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Src-Family Kinases/metabolism"'
Autor:
Valérie Olivier, Isabelle Roth, Khalil Udwan, Alexandra Chassot, Olivier Staub, Yubao Wang, Suresh Ramakrishnan, Eric Féraille, Ali Sassi
Publikováno v:
American journal of physiology. Renal physiology., Vol. 321, No 5 (2021) pp. F645-F655
Fine tuning of Na + reabsorption takes place along the aldosterone-sensitive distal nephron (ASDN) which includes the collecting duct (CD) where it is mainly regulated by aldosterone. In the CD,Na + reabsorption is mediated by the epithelial sodium c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efc6ca655583c3cf8e68a52902ca4b8
https://pubmed.ncbi.nlm.nih.gov/34605273
https://pubmed.ncbi.nlm.nih.gov/34605273
Autor:
Ana Magalhães, Teresa Canedo, Renata L. Alves, Ana M. F. P. Silva, Sandra H. Vaz, Tiago Almeida, Renato Socodato, Cátia M. Silva, Ana M. Sebastião, João B. Relvas, António F. Ambrósio, Cord Brakebusch, Joana F. Henriques, Roberto Paes-de-Carvalho, Teresa Summavielle, Filipa I. Baptista, João P. Magalhães, Artur Rodrigues, Camila C. Portugal, Vanessa Coelho-Santos
Publikováno v:
Socodato, R, Portugal, C C, Canedo, T, Rodrigues, A, Almeida, T O, Henriques, J F, Vaz, S H, Magalhães, J, Silva, C M, Baptista, F I, Alves, R L, Coelho-Santos, V, Silva, A P, Paes-de-Carvalho, R, Magalhães, A, Brakebusch, C, Sebastião, A M, Summavielle, T, Ambrósio, A F & Relvas, J B 2020, ' Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration ', Cell Reports, vol. 31, no. 12, 107796, pp. 1-29 . https://doi.org/10.1016/j.celrep.2020.107796
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cell Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cell Reports
© 2020 The Author(s). Creative Commons Attribution (CC BY 4.0)
Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in
Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb571fceba1952acaecbe0bcbe6bc791
https://curis.ku.dk/portal/da/publications/microglia-dysfunction-caused-by-the-loss-of-rhoa-disrupts-neuronal-physiology-and-leads-to-neurodegeneration(af46c589-efa7-462d-8150-2a9c7d52e48a).html
https://curis.ku.dk/portal/da/publications/microglia-dysfunction-caused-by-the-loss-of-rhoa-disrupts-neuronal-physiology-and-leads-to-neurodegeneration(af46c589-efa7-462d-8150-2a9c7d52e48a).html
Autor:
Manuela Sarti, Andrea Alimonti, Ilaria Guccini, Andrea Rinaldi, Erica Montani, Carlo V. Catapano, Ramón García-Escudero, Filippo Montemurro, Tiziano Bernasocchi, Sandra Pinton, Francesco Bertoni, Abdullah Alajati
Publikováno v:
Cell Reports, Vol 11, Iss 4, Pp 564-576 (2015)
Cell Reports, vol. 11, no. 4, pp. 564-576
Cell Reports, vol. 11, no. 4, pp. 564-576
SummaryUnderstanding the molecular pathways that contribute to the aggressive behavior of HER2-positive breast cancers may aid in the development of novel therapeutic interventions. Here, we show that CDCP1 and HER2 are frequently co-overexpressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047f3a0549cf88ab2c447ece811368a4
http://www.sciencedirect.com/science/article/pii/S221112471500323X
http://www.sciencedirect.com/science/article/pii/S221112471500323X
Autor:
Edward Málaga-Trillo, Katharina Ochs
Prions and Amyloid beta (Aβ) peptides induce synaptic damage via complex mechanisms that include the pathological alteration of intracellular signaling cascades. The host-encoded cellular prion protein (PrPC) acts as a high-affinity cell surface rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62396880d72148b0339d7bcf3584a0e
https://hdl.handle.net/20.500.12866/5113
https://hdl.handle.net/20.500.12866/5113
Autor:
Sempou, Emily, Biasini, Emiliano, Pinzon-Olejua, Alejandro, Harris, David-A., Málaga Trillo, George Edward
BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, PrP-1-dependent signals control c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3932::910bf7dfa2d7e44c0f7079f33d57515d
https://hdl.handle.net/20.500.12866/5160
https://hdl.handle.net/20.500.12866/5160
Autor:
François Mach, Maria Bertolotto, Franco Dallegri, Luciano Ottonello, Fabienne Burger, Fabrizio Montecucco, Giordano Bianchi, Ana Da Costa, Sabine Steffens
Publikováno v:
Cellular Signalling, Vol. 20, No 3 (2008) pp. 557-68
Strong evidence suggests that neutrophils may play an active role in acute and chronic inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. Given the role of pro-inflammatory cytokine TNF-alpha in these inflammatory processes, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecf36e3d1aeb659026b4b1ef3df903b
https://doi.org/10.1016/j.cellsig.2007.11.008
https://doi.org/10.1016/j.cellsig.2007.11.008
Autor:
Natalia A. Ignatenko, Dora Cavallo-Medved, Eugene W. Gerner, Bonnie F. Sloane, Rebecca S. Henkhaus, Upal K. Basu Roy
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 2, Pp 140-148 (2008)
Biological Sciences Publications
Biological Sciences Publications
Kallikreins are secreted proteases that may play a functional role and/or serve as a serum biomarker for the presence or progression of certain types of cancers. Kallikrein 6 (KLK6) has been shown to be upregulated in several types of cancers, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bebb353bd258152b138cba27d86c59
http://www.sciencedirect.com/science/article/pii/S1476558608800607
http://www.sciencedirect.com/science/article/pii/S1476558608800607
Publikováno v:
Oncotarget, vol. 6, no. 16, pp. 14300-14317
Oncotarget
Oncotarget
Carcinoma-associated fibroblasts were reported to promote colorectal cancer (CRC) invasion by secreting motility factors and extracellular matrix processing enzymes. Less is known whether fibroblasts may induce CRC cancer cell motility by contact- de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4928391e9aca15e991489acebd86ef05
https://serval.unil.ch/resource/serval:BIB_AD236634E8C0.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_AD236634E8C0.P001/REF.pdf
Autor:
John M. Leong, Cláudia Brito, Didier F. Vingadassalom, David W. Holden, Rui Cruz, Rafael Custódio, Sandra Maria Zákia Lian Sousa, Maria Teresa Almeida, Hugo Osório, Francisco Mesquita, Mariana Martins, Didier Cabanes
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Bacterial pathogens often interfere with host tyrosine phosphorylation cascades to control host responses and cause infection. Given the role of tyrosine phosphorylation events in different human infections and our previous results showing the activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85834e64d77a9214e316763a4fdefb7
Autor:
Christian Fuhrer, Jean-Charles Hoda, R. Ogier, Andreas Wiesner, Mario Raggenbass, Geraldine Allaman, Eric Charpantier, Dominik Feuerbach, Daniel Bertrand, Kyung-Hye Huh
Publikováno v:
Journal of Neuroscience, Vol. 25, No 43 (2005) pp. 9836-9849
Nicotine, a component of tobacco, is highly addictive but possesses beneficial properties such as cognitive improvements and memory maintenance. Involved in these processes is the neuronal nicotinic acetylcholine receptor (nAChR) α7, whose activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4537d4e37a7df3b06ff3f56ecf5cbbe2
https://doi.org/10.1523/jneurosci.3497-05.2005
https://doi.org/10.1523/jneurosci.3497-05.2005